| Peer-Reviewed

The Importance of Lymphovascular Invasion at Radical Cystectomy

Received: 11 December 2014     Accepted: 11 February 2015     Published: 26 February 2015
Views:       Downloads:
Abstract

Objectives: To investigate relationship between the lymphovascular invasion(LVI) and tumor characteristics and to evaluate effect on survival of LVI in patients who underwent radical cystectomy because of bladder cancer. Materials and Methods: Five hundred and six patients were enrolled the study between 1990 and 2013. Patients were divided into two groups in terms of lymphovascular invasion at final pathology after radical cystectomy. There were 108 patients with LVI(group1) and 244 patients without LVI(group2). Both groups were compared in terms of clinicopathologic features and survival. Results: There was no statically different for gender in both group(p=0,222).Lymh node involvement, grade, and p T stage were higher significantly in group 1(p<0,05). Positive lymph node number was 2.3±3.1 in group 1 and 0.6 ± 2.1 in group 2(p<0.001). Lymph node density was 24.3±30.1 in group 1 and 5.6±9.2 in group 2 (p<0.001).Estimated mean survival time was 27.2±3.4 months in group 1 and 80.2 ± 8.1 months in group 2 (p<0.001). Conclusions: Lymphovascular invasion is an independent prognostic factor for disease specific survival and effects survival negatively in patients who underwent radical cystectomy for bladder cancer. Patients with lymphovascular invasion should be considered for close monitoring after cystectomy.

Published in Clinical Medicine Research (Volume 4, Issue 2)
DOI 10.11648/j.cmr.20150402.12
Page(s) 34-37
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Lymphovascular Invasion (LVI), Radical Cystectomy, Survival, Urethelial Carcinoma

References
[1] Ploeg M, Aben KK, Kiemeney LA. The present and future burden of urinary bladder cancer in the world. World J Urol, 27(3):289-93, 2009.
[2] Vaidya A, Soloway MS, Hawke C, et al. De novo muscle invasive bladder cancer: is there a change in trend? J Urol, 165(1):47-50, 2001.
[3] Prout GR Jr, Griffin PP, Shipley WU. Bladder carcinoma as a systemic disease. Cancer, 43(6):2532-9, 1979.
[4] Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, Skinner E, Bochner B, Thangathurai D, Mikhail M, Raghavan D and Skinner DG. Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol, 19(3):666-675, 2001.
[5] Bassi P, Ferrante GD, Piazza N, Spinadin R, Carando R, Pappagallo G and Pagano F. Prognostic factors of outcome after radical cystectomy for bladder cancer: a retrospective study of a homogeneous patient cohort. J Urol, 161(5): 1494-7, 1999.
[6] Herrmann E, Stöter E, Van Ophoven A, Bierer S, Bolenz C, Hertle L and Christian Wülfing. The prognostic impact of pelvic lymph node metastasis and lymphovascular invasion on bladder cancer. Int J Urol, 15:607-611, 2008.
[7] Karakiewicz PI, Shariat SF, Palapattu GS, Gilad AE, Lotan Y, Rogers CG, Vazina A, Gupta A, Bastian PJ, Perrotte P, Sagalowsky AI, Schoenberg M and Lerner SP. Nomogram for predicting disease recurrence after radical cystectomy for transitional cell carcinoma of the bladder. J Urol, 176: 1354-1362, 2006.
[8] Kunju LP, You L, Zhang Y, Daignault S, Montie JE and Lee CT. Lymphovascular invasion of urothelial cancer in matched transurethral bladder tumor resection and radical cystectomy specimens. J Urol, 180:1928-1932, 2008.
[9] Canter D, Guzzo T, Resnick M, Magerfleisch L, Sonnad S, Bergey M, Tomazewski J, Vaughn D, Van Arsdalen K and Malkowicz B. The presence of lymphovascular invasion in radical cystectomy specimens from patients with urothelial carcinoma portends a poor clinical prognosis. BJU Int,102(8): 952-927,2008.
[10] Lopez JI, Angulo JC. The prognostic significance of vascular invasion in stage T1 bladder cancer. Histopathology, 27:27-33, 2008.
[11] Schoppmann, SF.; Bayer, G.; Aumayr, K.; Taucher, S.; Geleff, S.; Rudas, M.; Kubista, E.; Hausmaninger, H. et al. "Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer.". Ann Surg, 240 (2): 306–12,2004.
[12] Fang, WL.; Chang, SC.; Lin, JK.; Wang, HS.; Yang, SH.; Jiang, JK.; Chen, WC.; Lin, TC "Metastatic potential in T1 and T2 colorectal cancer." Hepatogastroenterology, 52 (66): 1688–91, 2005.
[13] Moreira, LF.; Kenmotsu, M.; Gochi, A.; Tanaka, N.; Orita, K "Lymphovascular and neural invasion in low-lying rectal carcinoma.". Cancer Detect Prev, 23 (2): 123–8, 1999.
[14] Jaeger TM, Weidner N, Chew K, et al. Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancer. J Urol, 154:69-71, 1999.
[15] Hara S, Miyake H, Fujisawa M, et al. Prognostic variables in patients who have undergone radical cystectomy for transitional cell carcinoma of the bladder. Jpn J Clin Oncol, 31:399-402, 2001.
[16] Herrmann E, Stöter E, Van Ophoven A, Bierer S, Bolenz C, Hertle L and Christian Wülfing. The prognostic impact of pelvic lymph node metastasis and lymphovascular invasion on bladder cancer. Int J Urol, 15: 607-611, 2008.
[17] Branchereau J, Larue S, Vayleux B, Karam G, Bouchot O, Rigaud J. Prognostic value of the lymphovascular invasion in high-grade stage pT1 bladder cancer. Clin Genitourin Cancer, Jun; 11(2):182-8, 2013.
[18] Tilki D, Shariat SF, Lotan Y, Rink M, Karakiewicz PI, Schoenberg MP, Lerner SP, Sonpavde G, Sagalowsky AI, Gupta A. Lymphovascular invasion is independently associated with bladder cancer recurrence and survival in patients with final stage T1 disease and negative lymph nodes after radical cystectomy. BJU Int, Jun;111(8):1215-21,2013.
[19] Leissner J, Hohenfellner R, Thuroff JW, Wolf HK. Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis. BJU Int, 85:817-823, 2003.
[20] Stein JP, Cai J, Groshen S, Skinner DG. Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: concept of lymph node density. J Urol, 170:35-41, 2003.
[21] Herr HW. Superiority of ratio based lymph node staging for bladder cancer. J Urol, 169: 943–5, 2003.
Cite This Article
  • APA Style

    Sacit Nuri Gorgel, Osman Kose, Ozan Horsanalı, Evren Sahin, Ugur Balci, et al. (2015). The Importance of Lymphovascular Invasion at Radical Cystectomy. Clinical Medicine Research, 4(2), 34-37. https://doi.org/10.11648/j.cmr.20150402.12

    Copy | Download

    ACS Style

    Sacit Nuri Gorgel; Osman Kose; Ozan Horsanalı; Evren Sahin; Ugur Balci, et al. The Importance of Lymphovascular Invasion at Radical Cystectomy. Clin. Med. Res. 2015, 4(2), 34-37. doi: 10.11648/j.cmr.20150402.12

    Copy | Download

    AMA Style

    Sacit Nuri Gorgel, Osman Kose, Ozan Horsanalı, Evren Sahin, Ugur Balci, et al. The Importance of Lymphovascular Invasion at Radical Cystectomy. Clin Med Res. 2015;4(2):34-37. doi: 10.11648/j.cmr.20150402.12

    Copy | Download

  • @article{10.11648/j.cmr.20150402.12,
      author = {Sacit Nuri Gorgel and Osman Kose and Ozan Horsanalı and Evren Sahin and Ugur Balci and Kutan Ozer and Cengiz Girgin},
      title = {The Importance of Lymphovascular Invasion at Radical Cystectomy},
      journal = {Clinical Medicine Research},
      volume = {4},
      number = {2},
      pages = {34-37},
      doi = {10.11648/j.cmr.20150402.12},
      url = {https://doi.org/10.11648/j.cmr.20150402.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20150402.12},
      abstract = {Objectives: To investigate relationship between the lymphovascular invasion(LVI) and tumor characteristics and to evaluate effect on survival of LVI in patients who underwent radical cystectomy because of bladder cancer. Materials and Methods: Five hundred and six patients were enrolled the study between 1990 and 2013. Patients were divided into two groups in terms of lymphovascular invasion at final pathology after radical cystectomy. There were 108 patients with LVI(group1) and 244 patients without LVI(group2). Both groups were compared in terms of clinicopathologic features and survival. Results: There was no statically different for gender in both group(p=0,222).Lymh node involvement, grade, and p T stage were higher significantly in group 1(p<0,05). Positive lymph node number was 2.3±3.1 in group 1 and 0.6 ± 2.1 in group 2(p<0.001). Lymph node density was 24.3±30.1 in group 1 and 5.6±9.2 in group 2 (p<0.001).Estimated mean survival time was 27.2±3.4 months in group 1 and 80.2 ± 8.1 months in group 2 (p<0.001). Conclusions: Lymphovascular invasion is an independent prognostic factor for disease specific survival and effects survival negatively in patients who underwent radical cystectomy for bladder cancer. Patients with lymphovascular invasion should be considered for close monitoring after cystectomy.},
     year = {2015}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - The Importance of Lymphovascular Invasion at Radical Cystectomy
    AU  - Sacit Nuri Gorgel
    AU  - Osman Kose
    AU  - Ozan Horsanalı
    AU  - Evren Sahin
    AU  - Ugur Balci
    AU  - Kutan Ozer
    AU  - Cengiz Girgin
    Y1  - 2015/02/26
    PY  - 2015
    N1  - https://doi.org/10.11648/j.cmr.20150402.12
    DO  - 10.11648/j.cmr.20150402.12
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 34
    EP  - 37
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20150402.12
    AB  - Objectives: To investigate relationship between the lymphovascular invasion(LVI) and tumor characteristics and to evaluate effect on survival of LVI in patients who underwent radical cystectomy because of bladder cancer. Materials and Methods: Five hundred and six patients were enrolled the study between 1990 and 2013. Patients were divided into two groups in terms of lymphovascular invasion at final pathology after radical cystectomy. There were 108 patients with LVI(group1) and 244 patients without LVI(group2). Both groups were compared in terms of clinicopathologic features and survival. Results: There was no statically different for gender in both group(p=0,222).Lymh node involvement, grade, and p T stage were higher significantly in group 1(p<0,05). Positive lymph node number was 2.3±3.1 in group 1 and 0.6 ± 2.1 in group 2(p<0.001). Lymph node density was 24.3±30.1 in group 1 and 5.6±9.2 in group 2 (p<0.001).Estimated mean survival time was 27.2±3.4 months in group 1 and 80.2 ± 8.1 months in group 2 (p<0.001). Conclusions: Lymphovascular invasion is an independent prognostic factor for disease specific survival and effects survival negatively in patients who underwent radical cystectomy for bladder cancer. Patients with lymphovascular invasion should be considered for close monitoring after cystectomy.
    VL  - 4
    IS  - 2
    ER  - 

    Copy | Download

Author Information
  • Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey

  • Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey

  • Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey

  • Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey

  • Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey

  • Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey

  • Sections