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Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance

Received: 9 March 2022     Accepted: 24 March 2022     Published: 26 April 2022
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Abstract

Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m2, were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville.

Published in Cardiology and Cardiovascular Research (Volume 6, Issue 2)
DOI 10.11648/j.ccr.20220602.12
Page(s) 55-59
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

TNF Alpha, Adiponectin, Obesity, Insulin Resistance, Bantu, Brazzaville

References
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  • APA Style

    Danny Mafuta-Munganga, Benjamin Longo-Mbenza, Reine Freudlendrich Eboka-Loumingou Sakou, Etienne Mokondjimobe, Gombet Thierry Raoul Alexis, et al. (2022). Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiology and Cardiovascular Research, 6(2), 55-59. https://doi.org/10.11648/j.ccr.20220602.12

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    ACS Style

    Danny Mafuta-Munganga; Benjamin Longo-Mbenza; Reine Freudlendrich Eboka-Loumingou Sakou; Etienne Mokondjimobe; Gombet Thierry Raoul Alexis, et al. Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiol. Cardiovasc. Res. 2022, 6(2), 55-59. doi: 10.11648/j.ccr.20220602.12

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    AMA Style

    Danny Mafuta-Munganga, Benjamin Longo-Mbenza, Reine Freudlendrich Eboka-Loumingou Sakou, Etienne Mokondjimobe, Gombet Thierry Raoul Alexis, et al. Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance. Cardiol Cardiovasc Res. 2022;6(2):55-59. doi: 10.11648/j.ccr.20220602.12

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  • @article{10.11648/j.ccr.20220602.12,
      author = {Danny Mafuta-Munganga and Benjamin Longo-Mbenza and Reine Freudlendrich Eboka-Loumingou Sakou and Etienne Mokondjimobe and Gombet Thierry Raoul Alexis and Moise Mvitu and Mireille Nganga and Christian Kisoka Lusunsi},
      title = {Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance},
      journal = {Cardiology and Cardiovascular Research},
      volume = {6},
      number = {2},
      pages = {55-59},
      doi = {10.11648/j.ccr.20220602.12},
      url = {https://doi.org/10.11648/j.ccr.20220602.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20220602.12},
      abstract = {Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m2, were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Relationship BetweenTumor Necrosis Factor Alpha, Adiponectin and Metabolic Parameters in Bantu Congolese at Brazzaville with and Without Insulin Resistance
    AU  - Danny Mafuta-Munganga
    AU  - Benjamin Longo-Mbenza
    AU  - Reine Freudlendrich Eboka-Loumingou Sakou
    AU  - Etienne Mokondjimobe
    AU  - Gombet Thierry Raoul Alexis
    AU  - Moise Mvitu
    AU  - Mireille Nganga
    AU  - Christian Kisoka Lusunsi
    Y1  - 2022/04/26
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ccr.20220602.12
    DO  - 10.11648/j.ccr.20220602.12
    T2  - Cardiology and Cardiovascular Research
    JF  - Cardiology and Cardiovascular Research
    JO  - Cardiology and Cardiovascular Research
    SP  - 55
    EP  - 59
    PB  - Science Publishing Group
    SN  - 2578-8914
    UR  - https://doi.org/10.11648/j.ccr.20220602.12
    AB  - Back ground: Tumor necrosis factor-alpha (TNF-α), adiponectin (ADP) and C-reactive protein (CRP) are associated with the risk of cardiovascular or non communicable diseases. Aims: To evaluate the association between TNF-α, ADP, CRP and metabolic markers in Congelese Bantu from Brazzaville. Methods: A cross-sectional case-control study was conducted during the period from July 2018 to February 2021. A total of 233 participants were recruited then divided into 130 healthy participants (control group) and 103 insulin resistant patients (case group). The Spearman correlation coefficient was calculated in order to search for an association between TNFα, ADP and the metabolic markers. An exponential nonlinear regression was used for the analysis of the association between TNFα (dependent variable) and CRP. Results: Participants were aged of 45.5 ± 13.1 years with a median BMI of 25.4 kg/m2, were included in this study. The median values of TNFα, CRP, ADP and HOMA-IR were 96.2 pg/mL, 12.3 mg/L, 8.6 ng/mL and 2.3, respectively. TNFα was positively correlated with anthropometric parameters, CRP and insulin resistance. In contrast, ADP was negatively correlated with anthropometric parameters, CRP and insulin resistance. In control group, the equation was written as TNF alpha = 187 * (1 - 0.96CRP). The model shows that CRP explains 84.62% of the variability of TNFα in healthy participants. In case group, the equation was written as TNF alpha = 186.4 * (1 - 0.95CRP). The model shows that CRP explains 93.65% of the variability of TNFα in insulin-resistant participants. Conclusion: TNF alpha and ADP are associated at NC, WC, WHR, WHtR, LDL, CRP and insulin resistance in Congolese Bantu from Brazzaville.
    VL  - 6
    IS  - 2
    ER  - 

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Author Information
  • Department of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo

  • Department of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo

  • Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

  • Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

  • Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo

  • Faculty of Health Sciences, Kongo University, Kongo-Central, Democratic Republic of Congo

  • Department of Clinical Biology, Faculty of Medicine, University of Kinshasa, Kinshasa, DR of Congo

  • Department of Public Health, Lomo University of Research, Kinshasa, Democratic Republic of Congo

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