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Low-Dose Dabigatran May Be Safely Used as an Alternative to Warfarin for Peri-Procedural Anticoagulation During Atrial Fibrillation Ablation

Received: 6 October 2018     Accepted: 24 October 2018     Published: 19 December 2018
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Abstract

Peri-procedural anticoagulation for atrial fibrillation (AF) ablation must be optimized to reduce the occurrence of bleeding and thromboembolic complications. In this study, the safety of two anticoagulants were compared between the commonly used warfarin and a potential alternative, orally administered low-dose (110 mg bid) dabigatran. A total of 117 Han Chinese patients undergoing AF ablation were included in the study. In all, 67 patients were administered dabigatran (110 mg) twice daily, while the other 50 received a therapeutically effective dose of warfarin. Thromboembolic and bleeding complications were compared between the two groups. No significant baseline differences were found between the groups. Only one thromboembolic complication (2.0%) occurred in the warfarin group, while no complications occurred in the dabigatran group (p = 0.43). Compared to the warfarin group, the dabigatran group showed a similar rate of major bleeding events (2.0% vs. 0; p = 0.43), but a significantly lower rate of minor bleeding events (9.0% vs. 22%; p = 0.048), total bleeding events (9% vs. 24%; p = 0.03), and bleeding and thromboembolic complications taken together (9% vs. 26%; p = 0.01). In Conclusion, the incidence of minor bleeding events after AF ablation was lower in those administered low-dose dabigatran (110 mg bid) than in those administered warfarin, while the risks of thromboembolic and major bleeding complications were similar between the two groups. This result indicates that low-dose dabigatran would be safer than warfarin in Chinese patients undergoing AF ablation.

Published in Cardiology and Cardiovascular Research (Volume 2, Issue 4)
DOI 10.11648/j.ccr.20180204.13
Page(s) 83-90
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Dabigatran, Warfarin, Atrial Fibrillation, Catheter Ablation, Anticoagulation

References
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Cite This Article
  • APA Style

    Haixia Xu, Yanmin Zhu, Ying Hua, Yinhao Huang, Qi Lu. (2018). Low-Dose Dabigatran May Be Safely Used as an Alternative to Warfarin for Peri-Procedural Anticoagulation During Atrial Fibrillation Ablation. Cardiology and Cardiovascular Research, 2(4), 83-90. https://doi.org/10.11648/j.ccr.20180204.13

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    ACS Style

    Haixia Xu; Yanmin Zhu; Ying Hua; Yinhao Huang; Qi Lu. Low-Dose Dabigatran May Be Safely Used as an Alternative to Warfarin for Peri-Procedural Anticoagulation During Atrial Fibrillation Ablation. Cardiol. Cardiovasc. Res. 2018, 2(4), 83-90. doi: 10.11648/j.ccr.20180204.13

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    AMA Style

    Haixia Xu, Yanmin Zhu, Ying Hua, Yinhao Huang, Qi Lu. Low-Dose Dabigatran May Be Safely Used as an Alternative to Warfarin for Peri-Procedural Anticoagulation During Atrial Fibrillation Ablation. Cardiol Cardiovasc Res. 2018;2(4):83-90. doi: 10.11648/j.ccr.20180204.13

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  • @article{10.11648/j.ccr.20180204.13,
      author = {Haixia Xu and Yanmin Zhu and Ying Hua and Yinhao Huang and Qi Lu},
      title = {Low-Dose Dabigatran May Be Safely Used as an Alternative to Warfarin for Peri-Procedural Anticoagulation During Atrial Fibrillation Ablation},
      journal = {Cardiology and Cardiovascular Research},
      volume = {2},
      number = {4},
      pages = {83-90},
      doi = {10.11648/j.ccr.20180204.13},
      url = {https://doi.org/10.11648/j.ccr.20180204.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20180204.13},
      abstract = {Peri-procedural anticoagulation for atrial fibrillation (AF) ablation must be optimized to reduce the occurrence of bleeding and thromboembolic complications. In this study, the safety of two anticoagulants were compared between the commonly used warfarin and a potential alternative, orally administered low-dose (110 mg bid) dabigatran. A total of 117 Han Chinese patients undergoing AF ablation were included in the study. In all, 67 patients were administered dabigatran (110 mg) twice daily, while the other 50 received a therapeutically effective dose of warfarin. Thromboembolic and bleeding complications were compared between the two groups. No significant baseline differences were found between the groups. Only one thromboembolic complication (2.0%) occurred in the warfarin group, while no complications occurred in the dabigatran group (p = 0.43). Compared to the warfarin group, the dabigatran group showed a similar rate of major bleeding events (2.0% vs. 0; p = 0.43), but a significantly lower rate of minor bleeding events (9.0% vs. 22%; p = 0.048), total bleeding events (9% vs. 24%; p = 0.03), and bleeding and thromboembolic complications taken together (9% vs. 26%; p = 0.01). In Conclusion, the incidence of minor bleeding events after AF ablation was lower in those administered low-dose dabigatran (110 mg bid) than in those administered warfarin, while the risks of thromboembolic and major bleeding complications were similar between the two groups. This result indicates that low-dose dabigatran would be safer than warfarin in Chinese patients undergoing AF ablation.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Low-Dose Dabigatran May Be Safely Used as an Alternative to Warfarin for Peri-Procedural Anticoagulation During Atrial Fibrillation Ablation
    AU  - Haixia Xu
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    AU  - Yinhao Huang
    AU  - Qi Lu
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    N1  - https://doi.org/10.11648/j.ccr.20180204.13
    DO  - 10.11648/j.ccr.20180204.13
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    JF  - Cardiology and Cardiovascular Research
    JO  - Cardiology and Cardiovascular Research
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    EP  - 90
    PB  - Science Publishing Group
    SN  - 2578-8914
    UR  - https://doi.org/10.11648/j.ccr.20180204.13
    AB  - Peri-procedural anticoagulation for atrial fibrillation (AF) ablation must be optimized to reduce the occurrence of bleeding and thromboembolic complications. In this study, the safety of two anticoagulants were compared between the commonly used warfarin and a potential alternative, orally administered low-dose (110 mg bid) dabigatran. A total of 117 Han Chinese patients undergoing AF ablation were included in the study. In all, 67 patients were administered dabigatran (110 mg) twice daily, while the other 50 received a therapeutically effective dose of warfarin. Thromboembolic and bleeding complications were compared between the two groups. No significant baseline differences were found between the groups. Only one thromboembolic complication (2.0%) occurred in the warfarin group, while no complications occurred in the dabigatran group (p = 0.43). Compared to the warfarin group, the dabigatran group showed a similar rate of major bleeding events (2.0% vs. 0; p = 0.43), but a significantly lower rate of minor bleeding events (9.0% vs. 22%; p = 0.048), total bleeding events (9% vs. 24%; p = 0.03), and bleeding and thromboembolic complications taken together (9% vs. 26%; p = 0.01). In Conclusion, the incidence of minor bleeding events after AF ablation was lower in those administered low-dose dabigatran (110 mg bid) than in those administered warfarin, while the risks of thromboembolic and major bleeding complications were similar between the two groups. This result indicates that low-dose dabigatran would be safer than warfarin in Chinese patients undergoing AF ablation.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, China

  • Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, China

  • Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, China

  • Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, China

  • Department of Cardiology, Affiliated Hospital of Nantong University, Nantong, China

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