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Prevalence of MDR-TB Based on Demographic Factors Among Patients Attending Nauth and St Patrick’s Hospital Mile 4 Abakaliki in Southeast Nigeria

Received: 28 August 2020     Accepted: 18 September 2020     Published: 22 March 2021
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Abstract

This study was designed to determine the prevalence of multi-drug resistant tuberculosis (MDR-TB) among pulmonary tuberculosis patients attending NnamdiAzikiwe University Teaching Hospital (NAUTH) Nnewi and St Patrick’s Hospital Mile 4 Abakaliki demographically. Patients with persistent cough for over two weeks were screened by Ziehl-Neelsen ZN technique for the presence of acid fast bacilli (AFB) in their sputum and a total of 103 patients with AFB positive sputum samples were recruited. The positive sputum samples were subjected to Xpert MTB/RIF assay (GeneXpert®, Cepheid USA) and culture on Lowestein Jensen medium for 42 days at 37°C. Drug susceptibility testing was done on the isolates using the nitrate reduction assay (NRA). Eighty-three 83 (80.6%) of the isolates were obtained from culture after suspected colonies were subjected to morphological, biochemical, and immunological tests and out of the 83 (80.6%) samples analysed by Xpert MTB/RIF assay 45 (67.2%) were rifampicin resistant. Age group 26-35 years showed the highest proportion of positive culture results (33.7%) followed by age group 18-25 (28.8%) years. Demographically, age group 26-35 years had a high prevalence rate of MDR-TB (50.0%) and female gender also showed high prevalence rate of MDR-RB (48.5%). Strikingly, educational status was significantly associated with MDR-TB (P=.020). St Patrick’s hospital had a high prevalence rate of MDR-TB (46.94%) when compared with NAUTH (38.9%) and these indicates that there is high prevalence of MDR-TB among patients with pulmonary TB in these sites. The demographic results of this study calls for urgent and serious intervention as MDR-TB prevalence is increasing even in the face of intense national TB control program.

Published in Chemical and Biomolecular Engineering (Volume 6, Issue 1)
DOI 10.11648/j.cbe.20210601.12
Page(s) 11-16
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Prevalence, MDR-TB, Demographic Factors, Patient

References
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Cite This Article
  • APA Style

    Chinenye Esther Okoro-Ani, Chima Innocent Ugbor, Stellamaris Ojiuzor Ibhawaegbele, Iniekong Philip Udoh, Chukwuma Paulinus Igweagu, et al. (2021). Prevalence of MDR-TB Based on Demographic Factors Among Patients Attending Nauth and St Patrick’s Hospital Mile 4 Abakaliki in Southeast Nigeria. Chemical and Biomolecular Engineering, 6(1), 11-16. https://doi.org/10.11648/j.cbe.20210601.12

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    ACS Style

    Chinenye Esther Okoro-Ani; Chima Innocent Ugbor; Stellamaris Ojiuzor Ibhawaegbele; Iniekong Philip Udoh; Chukwuma Paulinus Igweagu, et al. Prevalence of MDR-TB Based on Demographic Factors Among Patients Attending Nauth and St Patrick’s Hospital Mile 4 Abakaliki in Southeast Nigeria. Chem. Biomol. Eng. 2021, 6(1), 11-16. doi: 10.11648/j.cbe.20210601.12

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    AMA Style

    Chinenye Esther Okoro-Ani, Chima Innocent Ugbor, Stellamaris Ojiuzor Ibhawaegbele, Iniekong Philip Udoh, Chukwuma Paulinus Igweagu, et al. Prevalence of MDR-TB Based on Demographic Factors Among Patients Attending Nauth and St Patrick’s Hospital Mile 4 Abakaliki in Southeast Nigeria. Chem Biomol Eng. 2021;6(1):11-16. doi: 10.11648/j.cbe.20210601.12

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  • @article{10.11648/j.cbe.20210601.12,
      author = {Chinenye Esther Okoro-Ani and Chima Innocent Ugbor and Stellamaris Ojiuzor Ibhawaegbele and Iniekong Philip Udoh and Chukwuma Paulinus Igweagu and Ogechukwu Calista Dozie-Nwakile and Chima Gabriel Ezeah},
      title = {Prevalence of MDR-TB Based on Demographic Factors Among Patients Attending Nauth and St Patrick’s Hospital Mile 4 Abakaliki in Southeast Nigeria},
      journal = {Chemical and Biomolecular Engineering},
      volume = {6},
      number = {1},
      pages = {11-16},
      doi = {10.11648/j.cbe.20210601.12},
      url = {https://doi.org/10.11648/j.cbe.20210601.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cbe.20210601.12},
      abstract = {This study was designed to determine the prevalence of multi-drug resistant tuberculosis (MDR-TB) among pulmonary tuberculosis patients attending NnamdiAzikiwe University Teaching Hospital (NAUTH) Nnewi and St Patrick’s Hospital Mile 4 Abakaliki demographically. Patients with persistent cough for over two weeks were screened by Ziehl-Neelsen ZN technique for the presence of acid fast bacilli (AFB) in their sputum and a total of 103 patients with AFB positive sputum samples were recruited. The positive sputum samples were subjected to Xpert MTB/RIF assay (GeneXpert®, Cepheid USA) and culture on Lowestein Jensen medium for 42 days at 37°C. Drug susceptibility testing was done on the isolates using the nitrate reduction assay (NRA). Eighty-three 83 (80.6%) of the isolates were obtained from culture after suspected colonies were subjected to morphological, biochemical, and immunological tests and out of the 83 (80.6%) samples analysed by Xpert MTB/RIF assay 45 (67.2%) were rifampicin resistant. Age group 26-35 years showed the highest proportion of positive culture results (33.7%) followed by age group 18-25 (28.8%) years. Demographically, age group 26-35 years had a high prevalence rate of MDR-TB (50.0%) and female gender also showed high prevalence rate of MDR-RB (48.5%). Strikingly, educational status was significantly associated with MDR-TB (P=.020). St Patrick’s hospital had a high prevalence rate of MDR-TB (46.94%) when compared with NAUTH (38.9%) and these indicates that there is high prevalence of MDR-TB among patients with pulmonary TB in these sites. The demographic results of this study calls for urgent and serious intervention as MDR-TB prevalence is increasing even in the face of intense national TB control program.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Prevalence of MDR-TB Based on Demographic Factors Among Patients Attending Nauth and St Patrick’s Hospital Mile 4 Abakaliki in Southeast Nigeria
    AU  - Chinenye Esther Okoro-Ani
    AU  - Chima Innocent Ugbor
    AU  - Stellamaris Ojiuzor Ibhawaegbele
    AU  - Iniekong Philip Udoh
    AU  - Chukwuma Paulinus Igweagu
    AU  - Ogechukwu Calista Dozie-Nwakile
    AU  - Chima Gabriel Ezeah
    Y1  - 2021/03/22
    PY  - 2021
    N1  - https://doi.org/10.11648/j.cbe.20210601.12
    DO  - 10.11648/j.cbe.20210601.12
    T2  - Chemical and Biomolecular Engineering
    JF  - Chemical and Biomolecular Engineering
    JO  - Chemical and Biomolecular Engineering
    SP  - 11
    EP  - 16
    PB  - Science Publishing Group
    SN  - 2578-8884
    UR  - https://doi.org/10.11648/j.cbe.20210601.12
    AB  - This study was designed to determine the prevalence of multi-drug resistant tuberculosis (MDR-TB) among pulmonary tuberculosis patients attending NnamdiAzikiwe University Teaching Hospital (NAUTH) Nnewi and St Patrick’s Hospital Mile 4 Abakaliki demographically. Patients with persistent cough for over two weeks were screened by Ziehl-Neelsen ZN technique for the presence of acid fast bacilli (AFB) in their sputum and a total of 103 patients with AFB positive sputum samples were recruited. The positive sputum samples were subjected to Xpert MTB/RIF assay (GeneXpert®, Cepheid USA) and culture on Lowestein Jensen medium for 42 days at 37°C. Drug susceptibility testing was done on the isolates using the nitrate reduction assay (NRA). Eighty-three 83 (80.6%) of the isolates were obtained from culture after suspected colonies were subjected to morphological, biochemical, and immunological tests and out of the 83 (80.6%) samples analysed by Xpert MTB/RIF assay 45 (67.2%) were rifampicin resistant. Age group 26-35 years showed the highest proportion of positive culture results (33.7%) followed by age group 18-25 (28.8%) years. Demographically, age group 26-35 years had a high prevalence rate of MDR-TB (50.0%) and female gender also showed high prevalence rate of MDR-RB (48.5%). Strikingly, educational status was significantly associated with MDR-TB (P=.020). St Patrick’s hospital had a high prevalence rate of MDR-TB (46.94%) when compared with NAUTH (38.9%) and these indicates that there is high prevalence of MDR-TB among patients with pulmonary TB in these sites. The demographic results of this study calls for urgent and serious intervention as MDR-TB prevalence is increasing even in the face of intense national TB control program.
    VL  - 6
    IS  - 1
    ER  - 

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Author Information
  • Department of Medical Microbiology, Medical Laboratory Services, Enugu State University Teaching Hospital, Enugu, Nigeria

  • Department of Medical Laboratory Science, Ambrose Alli University, Ekpoma, Nigeria

  • Department of Medical Laboratory Science, Ambrose Alli University, Ekpoma, Nigeria

  • Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria

  • Department of Community Medicine, Enugu State University Teaching Hospital, Parklane, Enugu, Nigeria

  • Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria

  • Department of Medical Microbiology, Medical Laboratory Services, Enugu State University Teaching Hospital, Enugu, Nigeria

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