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Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant

Received: 9 December 2020     Accepted: 24 December 2020     Published: 12 January 2021
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Abstract

Aim: The clinical, 3D volumetric, and histological evaluation for effectiveness of addition of melatonin to β-tri calcium phosphate (β-TCP) in socket preservation after tooth extraction. Patients and methods: 24 patients were treatment planned for extraction of isolated hopeless mandibular teeth followed by delayed implant placement. They were divided randomly into two equal groups as follows: Group (A) sockets were grafted with β-TCP mixed with 1% melatonin, Group (B) included sockets were grafted with β-TCP alone. Clinical evaluation and Cone beam computed tomography (CBCT) were done immediately and 6 months postoperatively. Microscopic evaluation was performed after 6 months before implant insertion. All readings were recorded and analyzed statistically. Results: After 6 months, all clinical and radiographic parameters showed significant difference between the tested groups where Group (A) produced the highest mean values of bone density, bone height, and width followed by Group (B). Histological study referred to more maturation of bone in group A than group B. Where complete bone maturation occurred later in group II than group I. Conclusion: The results clearly concluded that melatonin had promotion effect for bone formation. Therefore, addition of melatonin to β-TCP has high successful effect in decrease bone resorption with increased bone density of alveolar ridge leading to preserve on 3-D volume of alveolar ridge after tooth extraction.

Published in Biomedical Sciences (Volume 7, Issue 1)
DOI 10.11648/j.bs.20210701.12
Page(s) 10-16
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Socket Preservation, Beta-tri-calcium Phosphate (β-TCP), Melatonin, Cone Beam Computed Tomography (CBCT)

References
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    Abdel Aziz Baiomy Abdullah, Mohamed Fouad Edrees, Ahmed Mohamed Bakry. (2021). Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant. Biomedical Sciences, 7(1), 10-16. https://doi.org/10.11648/j.bs.20210701.12

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    ACS Style

    Abdel Aziz Baiomy Abdullah; Mohamed Fouad Edrees; Ahmed Mohamed Bakry. Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant. Biomed. Sci. 2021, 7(1), 10-16. doi: 10.11648/j.bs.20210701.12

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    AMA Style

    Abdel Aziz Baiomy Abdullah, Mohamed Fouad Edrees, Ahmed Mohamed Bakry. Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant. Biomed Sci. 2021;7(1):10-16. doi: 10.11648/j.bs.20210701.12

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  • @article{10.11648/j.bs.20210701.12,
      author = {Abdel Aziz Baiomy Abdullah and Mohamed Fouad Edrees and Ahmed Mohamed Bakry},
      title = {Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant},
      journal = {Biomedical Sciences},
      volume = {7},
      number = {1},
      pages = {10-16},
      doi = {10.11648/j.bs.20210701.12},
      url = {https://doi.org/10.11648/j.bs.20210701.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20210701.12},
      abstract = {Aim: The clinical, 3D volumetric, and histological evaluation for effectiveness of addition of melatonin to β-tri calcium phosphate (β-TCP) in socket preservation after tooth extraction. Patients and methods: 24 patients were treatment planned for extraction of isolated hopeless mandibular teeth followed by delayed implant placement. They were divided randomly into two equal groups as follows: Group (A) sockets were grafted with β-TCP mixed with 1% melatonin, Group (B) included sockets were grafted with β-TCP alone. Clinical evaluation and Cone beam computed tomography (CBCT) were done immediately and 6 months postoperatively. Microscopic evaluation was performed after 6 months before implant insertion. All readings were recorded and analyzed statistically. Results: After 6 months, all clinical and radiographic parameters showed significant difference between the tested groups where Group (A) produced the highest mean values of bone density, bone height, and width followed by Group (B). Histological study referred to more maturation of bone in group A than group B. Where complete bone maturation occurred later in group II than group I. Conclusion: The results clearly concluded that melatonin had promotion effect for bone formation. Therefore, addition of melatonin to β-TCP has high successful effect in decrease bone resorption with increased bone density of alveolar ridge leading to preserve on 3-D volume of alveolar ridge after tooth extraction.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Clinical, Radiographic, and Histological Assessment of Socket Preservation Using Melatonin with Beta-Tri-Calcium Phosphate for Receiving Dental Implant
    AU  - Abdel Aziz Baiomy Abdullah
    AU  - Mohamed Fouad Edrees
    AU  - Ahmed Mohamed Bakry
    Y1  - 2021/01/12
    PY  - 2021
    N1  - https://doi.org/10.11648/j.bs.20210701.12
    DO  - 10.11648/j.bs.20210701.12
    T2  - Biomedical Sciences
    JF  - Biomedical Sciences
    JO  - Biomedical Sciences
    SP  - 10
    EP  - 16
    PB  - Science Publishing Group
    SN  - 2575-3932
    UR  - https://doi.org/10.11648/j.bs.20210701.12
    AB  - Aim: The clinical, 3D volumetric, and histological evaluation for effectiveness of addition of melatonin to β-tri calcium phosphate (β-TCP) in socket preservation after tooth extraction. Patients and methods: 24 patients were treatment planned for extraction of isolated hopeless mandibular teeth followed by delayed implant placement. They were divided randomly into two equal groups as follows: Group (A) sockets were grafted with β-TCP mixed with 1% melatonin, Group (B) included sockets were grafted with β-TCP alone. Clinical evaluation and Cone beam computed tomography (CBCT) were done immediately and 6 months postoperatively. Microscopic evaluation was performed after 6 months before implant insertion. All readings were recorded and analyzed statistically. Results: After 6 months, all clinical and radiographic parameters showed significant difference between the tested groups where Group (A) produced the highest mean values of bone density, bone height, and width followed by Group (B). Histological study referred to more maturation of bone in group A than group B. Where complete bone maturation occurred later in group II than group I. Conclusion: The results clearly concluded that melatonin had promotion effect for bone formation. Therefore, addition of melatonin to β-TCP has high successful effect in decrease bone resorption with increased bone density of alveolar ridge leading to preserve on 3-D volume of alveolar ridge after tooth extraction.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Al-Azhar University, Assiut, Egypt

  • Department of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology Faculty of Dental Medicine, Al-Azhar University, Assiut, Egypt

  • Department of Oral and Maxillofacial Radiology, Faculty of Dental Medicine, Minia University, Minya, Egypt

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