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Complicated Effect of He-Ne Laser Therapy on Pro-/Anti-Inflammatory Cytokines from Serum in Rats

Received: 23 October 2018     Accepted: 9 November 2018     Published: 5 December 2018
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Abstract

Helium-neon (He-Ne) laser is one of the most common low energy lasers used in physiotherapy for promoting wound healing. This study was about to investigate the effects of He-Ne laser therapy on the pro-/anti-inflammatory cytokines in rats up to 10 days of treatment. 16 non-pregnant female rats were divided into 4 groups randomly, 4 rats in each group. They are negative control (NC) group, positive control (PC) group, laser treatment (LA) group and erythromycin ointment (ER) treatment group. The LA group was treated with 25 mW of He-Ne laser for 30 min every day for 10 days, with 632.8 nm of wavelength immediately after three incisions were made on the mid-dorsal line of each rat. The results showed that He-Ne laser therapy could decrease the level of IL-1β compared with the PC and ER groups; while increase the level of IL-6 compared with the NC and ER groups, and the level of TNF-α compared with the PC and ER group. He-Ne laser therapy also increased the concentration of IL-10 compared with the other three groups, and the concentration of TGF-β compared with the NC and ER groups. These results indicated that laser acupuncture increased the production of IL-6, IL-10, TGF-β and TNF-α after 10 days of treatment, which was the proliferation stage of wound healing process, and the effect of He-Ne laser therapy on pro-inflammatory cytokines was not always consistent, which might be time-dependent of He-Ne laser treatment.

Published in Animal and Veterinary Sciences (Volume 6, Issue 5)
DOI 10.11648/j.avs.20180605.14
Page(s) 88-94
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

He-Ne Laser Therapy, Pro-inflammatory Cytokines, Anti-inflammatory Cytokines, Wound Healing

References
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Cite This Article
  • APA Style

    Wuren Ma, Yunpeng Fan, Jinyang Zuo, Zhao Chen, Jun Yuan, et al. (2018). Complicated Effect of He-Ne Laser Therapy on Pro-/Anti-Inflammatory Cytokines from Serum in Rats. Animal and Veterinary Sciences, 6(5), 88-94. https://doi.org/10.11648/j.avs.20180605.14

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    ACS Style

    Wuren Ma; Yunpeng Fan; Jinyang Zuo; Zhao Chen; Jun Yuan, et al. Complicated Effect of He-Ne Laser Therapy on Pro-/Anti-Inflammatory Cytokines from Serum in Rats. Anim. Vet. Sci. 2018, 6(5), 88-94. doi: 10.11648/j.avs.20180605.14

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    AMA Style

    Wuren Ma, Yunpeng Fan, Jinyang Zuo, Zhao Chen, Jun Yuan, et al. Complicated Effect of He-Ne Laser Therapy on Pro-/Anti-Inflammatory Cytokines from Serum in Rats. Anim Vet Sci. 2018;6(5):88-94. doi: 10.11648/j.avs.20180605.14

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  • @article{10.11648/j.avs.20180605.14,
      author = {Wuren Ma and Yunpeng Fan and Jinyang Zuo and Zhao Chen and Jun Yuan and Xiaoping Song},
      title = {Complicated Effect of He-Ne Laser Therapy on Pro-/Anti-Inflammatory Cytokines from Serum in Rats},
      journal = {Animal and Veterinary Sciences},
      volume = {6},
      number = {5},
      pages = {88-94},
      doi = {10.11648/j.avs.20180605.14},
      url = {https://doi.org/10.11648/j.avs.20180605.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20180605.14},
      abstract = {Helium-neon (He-Ne) laser is one of the most common low energy lasers used in physiotherapy for promoting wound healing. This study was about to investigate the effects of He-Ne laser therapy on the pro-/anti-inflammatory cytokines in rats up to 10 days of treatment. 16 non-pregnant female rats were divided into 4 groups randomly, 4 rats in each group. They are negative control (NC) group, positive control (PC) group, laser treatment (LA) group and erythromycin ointment (ER) treatment group. The LA group was treated with 25 mW of He-Ne laser for 30 min every day for 10 days, with 632.8 nm of wavelength immediately after three incisions were made on the mid-dorsal line of each rat. The results showed that He-Ne laser therapy could decrease the level of IL-1β compared with the PC and ER groups; while increase the level of IL-6 compared with the NC and ER groups, and the level of TNF-α compared with the PC and ER group. He-Ne laser therapy also increased the concentration of IL-10 compared with the other three groups, and the concentration of TGF-β compared with the NC and ER groups. These results indicated that laser acupuncture increased the production of IL-6, IL-10, TGF-β and TNF-α after 10 days of treatment, which was the proliferation stage of wound healing process, and the effect of He-Ne laser therapy on pro-inflammatory cytokines was not always consistent, which might be time-dependent of He-Ne laser treatment.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Complicated Effect of He-Ne Laser Therapy on Pro-/Anti-Inflammatory Cytokines from Serum in Rats
    AU  - Wuren Ma
    AU  - Yunpeng Fan
    AU  - Jinyang Zuo
    AU  - Zhao Chen
    AU  - Jun Yuan
    AU  - Xiaoping Song
    Y1  - 2018/12/05
    PY  - 2018
    N1  - https://doi.org/10.11648/j.avs.20180605.14
    DO  - 10.11648/j.avs.20180605.14
    T2  - Animal and Veterinary Sciences
    JF  - Animal and Veterinary Sciences
    JO  - Animal and Veterinary Sciences
    SP  - 88
    EP  - 94
    PB  - Science Publishing Group
    SN  - 2328-5850
    UR  - https://doi.org/10.11648/j.avs.20180605.14
    AB  - Helium-neon (He-Ne) laser is one of the most common low energy lasers used in physiotherapy for promoting wound healing. This study was about to investigate the effects of He-Ne laser therapy on the pro-/anti-inflammatory cytokines in rats up to 10 days of treatment. 16 non-pregnant female rats were divided into 4 groups randomly, 4 rats in each group. They are negative control (NC) group, positive control (PC) group, laser treatment (LA) group and erythromycin ointment (ER) treatment group. The LA group was treated with 25 mW of He-Ne laser for 30 min every day for 10 days, with 632.8 nm of wavelength immediately after three incisions were made on the mid-dorsal line of each rat. The results showed that He-Ne laser therapy could decrease the level of IL-1β compared with the PC and ER groups; while increase the level of IL-6 compared with the NC and ER groups, and the level of TNF-α compared with the PC and ER group. He-Ne laser therapy also increased the concentration of IL-10 compared with the other three groups, and the concentration of TGF-β compared with the NC and ER groups. These results indicated that laser acupuncture increased the production of IL-6, IL-10, TGF-β and TNF-α after 10 days of treatment, which was the proliferation stage of wound healing process, and the effect of He-Ne laser therapy on pro-inflammatory cytokines was not always consistent, which might be time-dependent of He-Ne laser treatment.
    VL  - 6
    IS  - 5
    ER  - 

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Author Information
  • College of Veterinary Medicine, Northwest A&F University, Yangling, P R China

  • College of Veterinary Medicine, Northwest A&F University, Yangling, P R China

  • College of Veterinary Medicine, Northwest A&F University, Yangling, P R China

  • College of Veterinary Medicine, Northwest A&F University, Yangling, P R China

  • Institute of Fisheries Engineering, Chinese Academy of Fishery Sciences, Beijing, P R China

  • College of Veterinary Medicine, Northwest A&F University, Yangling, P R China

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