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Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease

Received: 19 October 2018     Accepted: 12 November 2018     Published: 20 December 2018
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Abstract

Chronic Kidney Disease (CKD) patients are inactive and have reduced physical performance. The CKD lead to abnormalities in various systems including the hemostatic and oxidative systems. The platelet activation occurs with the participation of adenine nucleotides such as ATP and ADP. This nucleotides are part of a system calls purinergic signaling, that is a cell-cell communication pathway, present in several physiological mechanisms such as immune responses, pain, inflammation, cell proliferation, oxidative stress and platelet aggregation. In this work we evaluate the physical mobility, functional capacity and changes in oxidative profile and purinergic enzymes activity in patients with CKD during hemodialysis treatment before and after the protocol of resistance exercise (RE) development. Patients during hemodialysis section were recruited (n = 34). All patients underwent a RE three times a week for eight weeks. The data were analyzed in two moments: before the exercises (BE) and after the exercises (AE). Physical training significantly reduced the markers of oxidative stress after RE by increasing enzymatic and non-enzymatic antioxidant defenses. In addition, the activity of the enzymes of the purinergic system was significantly lower by ATP and AMP hydrolysis after RE. We showed, for the first time, that RE decreased significantly the oxidative stress markers after exercise when compared to previous exercise through increased enzymatic and non-enzymatic antioxidant defenses in CDK patients. These results reinforce the main role of RE in patients with chronic disease and future uses to increase the quality of life of CKD patients.

Published in American Journal of Sports Science (Volume 6, Issue 4)
DOI 10.11648/j.ajss.20180604.17
Page(s) 175-181
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Chronic Kidney Disease (CKD), Purinergic Signaling, Oxidative Stress, Platelet Aggregation, Resistance Exercise

References
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Cite This Article
  • APA Style

    Matheus Pelinski da Silveira, Aline Mânica, João Victor Garcia de Souza, Cíntia Krilow, Pedro Augusto Cavagni Ambrosi, et al. (2018). Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease. American Journal of Sports Science, 6(4), 175-181. https://doi.org/10.11648/j.ajss.20180604.17

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    ACS Style

    Matheus Pelinski da Silveira; Aline Mânica; João Victor Garcia de Souza; Cíntia Krilow; Pedro Augusto Cavagni Ambrosi, et al. Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease. Am. J. Sports Sci. 2018, 6(4), 175-181. doi: 10.11648/j.ajss.20180604.17

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    AMA Style

    Matheus Pelinski da Silveira, Aline Mânica, João Victor Garcia de Souza, Cíntia Krilow, Pedro Augusto Cavagni Ambrosi, et al. Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease. Am J Sports Sci. 2018;6(4):175-181. doi: 10.11648/j.ajss.20180604.17

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  • @article{10.11648/j.ajss.20180604.17,
      author = {Matheus Pelinski da Silveira and Aline Mânica and João Victor Garcia de Souza and Cíntia Krilow and Pedro Augusto Cavagni Ambrosi and Cristiane Márcia Siepko and Beatriz Da Silva Rosa Bonadiman and Margarete Dulce Bagatini and Débora Tavares Resende e Silva},
      title = {Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease},
      journal = {American Journal of Sports Science},
      volume = {6},
      number = {4},
      pages = {175-181},
      doi = {10.11648/j.ajss.20180604.17},
      url = {https://doi.org/10.11648/j.ajss.20180604.17},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20180604.17},
      abstract = {Chronic Kidney Disease (CKD) patients are inactive and have reduced physical performance. The CKD lead to abnormalities in various systems including the hemostatic and oxidative systems. The platelet activation occurs with the participation of adenine nucleotides such as ATP and ADP. This nucleotides are part of a system calls purinergic signaling, that is a cell-cell communication pathway, present in several physiological mechanisms such as immune responses, pain, inflammation, cell proliferation, oxidative stress and platelet aggregation. In this work we evaluate the physical mobility, functional capacity and changes in oxidative profile and purinergic enzymes activity in patients with CKD during hemodialysis treatment before and after the protocol of resistance exercise (RE) development. Patients during hemodialysis section were recruited (n = 34). All patients underwent a RE three times a week for eight weeks. The data were analyzed in two moments: before the exercises (BE) and after the exercises (AE). Physical training significantly reduced the markers of oxidative stress after RE by increasing enzymatic and non-enzymatic antioxidant defenses. In addition, the activity of the enzymes of the purinergic system was significantly lower by ATP and AMP hydrolysis after RE. We showed, for the first time, that RE decreased significantly the oxidative stress markers after exercise when compared to previous exercise through increased enzymatic and non-enzymatic antioxidant defenses in CDK patients. These results reinforce the main role of RE in patients with chronic disease and future uses to increase the quality of life of CKD patients.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Exercise Changes Oxidative Profile and Purinergic Enzymes Activity in Kidney Disease
    AU  - Matheus Pelinski da Silveira
    AU  - Aline Mânica
    AU  - João Victor Garcia de Souza
    AU  - Cíntia Krilow
    AU  - Pedro Augusto Cavagni Ambrosi
    AU  - Cristiane Márcia Siepko
    AU  - Beatriz Da Silva Rosa Bonadiman
    AU  - Margarete Dulce Bagatini
    AU  - Débora Tavares Resende e Silva
    Y1  - 2018/12/20
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ajss.20180604.17
    DO  - 10.11648/j.ajss.20180604.17
    T2  - American Journal of Sports Science
    JF  - American Journal of Sports Science
    JO  - American Journal of Sports Science
    SP  - 175
    EP  - 181
    PB  - Science Publishing Group
    SN  - 2330-8540
    UR  - https://doi.org/10.11648/j.ajss.20180604.17
    AB  - Chronic Kidney Disease (CKD) patients are inactive and have reduced physical performance. The CKD lead to abnormalities in various systems including the hemostatic and oxidative systems. The platelet activation occurs with the participation of adenine nucleotides such as ATP and ADP. This nucleotides are part of a system calls purinergic signaling, that is a cell-cell communication pathway, present in several physiological mechanisms such as immune responses, pain, inflammation, cell proliferation, oxidative stress and platelet aggregation. In this work we evaluate the physical mobility, functional capacity and changes in oxidative profile and purinergic enzymes activity in patients with CKD during hemodialysis treatment before and after the protocol of resistance exercise (RE) development. Patients during hemodialysis section were recruited (n = 34). All patients underwent a RE three times a week for eight weeks. The data were analyzed in two moments: before the exercises (BE) and after the exercises (AE). Physical training significantly reduced the markers of oxidative stress after RE by increasing enzymatic and non-enzymatic antioxidant defenses. In addition, the activity of the enzymes of the purinergic system was significantly lower by ATP and AMP hydrolysis after RE. We showed, for the first time, that RE decreased significantly the oxidative stress markers after exercise when compared to previous exercise through increased enzymatic and non-enzymatic antioxidant defenses in CDK patients. These results reinforce the main role of RE in patients with chronic disease and future uses to increase the quality of life of CKD patients.
    VL  - 6
    IS  - 4
    ER  - 

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Author Information
  • Department of Medicine, Federal University of South Frontier, Chapecó, Brazil

  • Department of Medicine, Federal University of South Frontier, Chapecó, Brazil

  • Department of Medicine, Federal University of South Frontier, Chapecó, Brazil

  • Department of Health Sciences, Ibrate College, Curitiba, Brazil

  • Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, Brazil

  • Academic Coordination, Federal University of South Frontier, Chapecó, Brazil

  • Academic Coordination, Federal University of South Frontier, Chapecó, Brazil

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