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Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis

Received: 5 September 2023     Accepted: 25 September 2023     Published: 8 October 2023
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Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory, pruritic and relapsing skin disease, frequently originated in infants and young children. The objective of our study was to evaluate the clinical efficacy and quality of life in children with AD who were treated with mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months. Method: This prospective case control study was conducted in the University Hospital “Dr Dragiša Mišović”, Belgrade, Serbia, Hospital for Children’s Hospital for Lung diseases and Tb. The study enrolled 150 patients with AD aged between 3 and 17 years. 75 participants received the treatment: mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months as an add-on to standard AD treatment and 75 of them were treated according to standard protocols for AD. Results: There is a statistically significant difference in SCORAD value before and after the treatment between the groups. Discussion: Our study was the first that assess the efficacy of a mixture of 3 x 109 CFU probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri® form for better resorption and 1200 IJ Vitamin D3 in children with atopic dermatitis. Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.

Published in American Journal of Pediatrics (Volume 9, Issue 4)
DOI 10.11648/j.ajp.20230904.11
Page(s) 186-192
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Children, Atopic Dermatitis, Probiotics

References
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    Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Sladjana Mihajlovic, Marco Caminati, et al. (2023). Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. American Journal of Pediatrics, 9(4), 186-192. https://doi.org/10.11648/j.ajp.20230904.11

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    ACS Style

    Ivana Filipovic; Olivera Ostojic; Vesna Vekovic; Sladjana Mihajlovic; Marco Caminati, et al. Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. Am. J. Pediatr. 2023, 9(4), 186-192. doi: 10.11648/j.ajp.20230904.11

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    AMA Style

    Ivana Filipovic, Olivera Ostojic, Vesna Vekovic, Sladjana Mihajlovic, Marco Caminati, et al. Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis. Am J Pediatr. 2023;9(4):186-192. doi: 10.11648/j.ajp.20230904.11

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  • @article{10.11648/j.ajp.20230904.11,
      author = {Ivana Filipovic and Olivera Ostojic and Vesna Vekovic and Sladjana Mihajlovic and Marco Caminati and Zorica Zivkovic},
      title = {Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis},
      journal = {American Journal of Pediatrics},
      volume = {9},
      number = {4},
      pages = {186-192},
      doi = {10.11648/j.ajp.20230904.11},
      url = {https://doi.org/10.11648/j.ajp.20230904.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230904.11},
      abstract = {Introduction: Atopic dermatitis (AD) is a chronic inflammatory, pruritic and relapsing skin disease, frequently originated in infants and young children. The objective of our study was to evaluate the clinical efficacy and quality of life in children with AD who were treated with mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months. Method: This prospective case control study was conducted in the University Hospital “Dr Dragiša Mišović”, Belgrade, Serbia, Hospital for Children’s Hospital for Lung diseases and Tb. The study enrolled 150 patients with AD aged between 3 and 17 years. 75 participants received the treatment: mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months as an add-on to standard AD treatment and 75 of them were treated according to standard protocols for AD. Results: There is a statistically significant difference in SCORAD value before and after the treatment between the groups. Discussion: Our study was the first that assess the efficacy of a mixture of 3 x 109 CFU probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri® form for better resorption and 1200 IJ Vitamin D3 in children with atopic dermatitis. Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Efficacy of Specially Formulated Combination Three Probiotic Strains with Vitamin D3 and Zn in Children with Atopic Dermatitis
    AU  - Ivana Filipovic
    AU  - Olivera Ostojic
    AU  - Vesna Vekovic
    AU  - Sladjana Mihajlovic
    AU  - Marco Caminati
    AU  - Zorica Zivkovic
    Y1  - 2023/10/08
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ajp.20230904.11
    DO  - 10.11648/j.ajp.20230904.11
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 186
    EP  - 192
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20230904.11
    AB  - Introduction: Atopic dermatitis (AD) is a chronic inflammatory, pruritic and relapsing skin disease, frequently originated in infants and young children. The objective of our study was to evaluate the clinical efficacy and quality of life in children with AD who were treated with mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months. Method: This prospective case control study was conducted in the University Hospital “Dr Dragiša Mišović”, Belgrade, Serbia, Hospital for Children’s Hospital for Lung diseases and Tb. The study enrolled 150 patients with AD aged between 3 and 17 years. 75 participants received the treatment: mixture of 3 x 109 CFU of 3 probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri form for better resorption and 1200 IJ Vitamin D3, once per day for 3 months as an add-on to standard AD treatment and 75 of them were treated according to standard protocols for AD. Results: There is a statistically significant difference in SCORAD value before and after the treatment between the groups. Discussion: Our study was the first that assess the efficacy of a mixture of 3 x 109 CFU probiotic strains Lactobacillus Casei BL 2401, Lactobacillus Salivarius BL 2201, Bifidobacterium Breve BL 3406 in combination with 7mg Zinc in Hypro-ri® form for better resorption and 1200 IJ Vitamin D3 in children with atopic dermatitis. Our study confirmed that regular treatment with this specific probiotic mixture significantly decreased pruritus and sleep problems and improved quality of life in highly atopic children with severe atopic dermatitis.
    VL  - 9
    IS  - 4
    ER  - 

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Author Information
  • Hospital for Gynecology and Obstetrics - Neonatology Department, University Hospital dr Dragisa Misovic, Begrade, Serbia

  • Children’s Hospital for Lung Diseases and Tb, University Hospital dr Dragisa Misovic, Belgrade, Serbia

  • Children’s Hospital for Lung Diseases and Tb, University Hospital dr Dragisa Misovic, Belgrade, Serbia

  • Hospital for Gynecology and Obstetrics - Neonatology Department, University Hospital dr Dragisa Misovic, Begrade, Serbia

  • Department of Medicine, Allergy Unit and Asthma Center, University of Verona, Verona, Italy

  • Children’s Hospital for Lung Diseases and Tb, University Hospital dr Dragisa Misovic, Belgrade, Serbia

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