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Congenital Mesoblastic Nephroma in a Newborn: Case Report

Received: 5 February 2023     Accepted: 13 March 2023     Published: 31 March 2023
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Abstract

Background: Congenital mesoblastic nephroma (CMN) is a rare mesenchymal renal tumor of the newborn. The objective of this study was to review the clinical particularities, paraclinical and therapeutic characteristics of this tumor. It is about a case report of pediatric patient admitted to a Pediatric Neonatal Reanimation, A. Harouchi Hospital, Ibn Rochd university Hospital centre, Casablanca. Results: We report the observation of a 4-day premature newborn who was hospitalized for exploration of an abdominal mass occupying the right flank since birth. Abdominal ultrasonography revealed a predominantly fleshy right solidocystic renal mass, a site of calcifications laminating the cortex, measuring 57x33x58, with minimal pyelocaliceal dilatation and diffuse infiltration of perrenal fat. The CT scan revealed a kidney increased in size, seat of a voluminous mass rather well limited, of tissue density, heterogeneous, seat of necrosis, realizing a sign of the spur, measuring 40x47x58mm. The diagnosis was confirmed by a kidney biopsy. Conclusion: Mesoblastic nephroma is considered a benign tumor. The diagnosis is discussed on the basis of clinical data, ultrasound and CT scan. Surgery is the primary treatment for NMC and is based on extended nephrectomy. Most patients with NMC have a favorable outcome, the overall prognosis is very good.

Published in American Journal of Pediatrics (Volume 9, Issue 1)
DOI 10.11648/j.ajp.20230901.17
Page(s) 55-58
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Renal Tumor, Congenital Mesoblastic Nephroma, Neonatology

References
[1] Howell CG, Othersan HB, Kiviat NE, Norkool P, Beckwith JB, D'Angio GJ. Therapy and outcome in 51 children with mesoblastic nephroma. A Report of the national Wilm’tumor study J. Paediatr Surg. 1982; 17: 826–831 11.
[2] P. W. Saula, G. P. HadleyPediatric non-wilms’ renal tumors: a third world experience World J Surg, 36 (3) (2012), pp. 565-572, 10.1007/s00268-011-1410-2,
[3] E. M. Chung, A. R. Graeber, R. M. ConranRenal tumors of childhood: radiologic-pathologic correlation part 1. the 1st decade RadioGraphics, 36 (2) (2016), pp. 499-522, 10.1148/rg.2016150230.
[4] Vido L, Carli M, Rizzoni G, et al. Congenital mesoblastic nephroma with hy-percalcemia. Pathogenetic role of prostaglandins. Am J PediatrHematol Oncol. 1986; 8: 149-52.
[5] E. Montaruli, V. Fouquet Prenatal diagnosis of congenital mesoblastic nephroma Fetal Diagn Ther, 33 (1) (2013), pp. 79-80, 10.1159/000336464.
[6] G. Chaudry, A. R. Perez-Atayde, B. Y. Ngan, M. Gundogan, A. Daneman Imaging of congenital mesoblastic nephroma with pathological correlation PediatrRadiol, 39 (10) (2009), pp. 1080-1086, 10.1007/s00247-009-1354-y).
[7] M. M. Sheth, G. Cai, T. R. GoodmanAIRP best cases in radiologic-pathologic correlation: congenital mesoblastic nephroma RadioGraphics, 32 (1) (2012), pp. 99-103, 10.1148/rg.321105228.
[8] E. M. Chung, G. E. Lattin, K. E. Fagen, et al. Renal tumors of childhood: radiologic-pathologic correlation Part 2. The 2nd decade: from the radiologic pathology archives RadioGraphics, 37 (5) (2017), pp. 1538-1558, 10.1148/rg.2017160189).
[9] V. Mallya, R. Arora, K. Gupta, U. SharmaCongenital mesoblastic Nephroma : a rare pédiatrie neoplasm kongenitalmezoblastikNefrom : nadir birPediatrikTumor (2013), pp. 58-61, 10.5146/tjpath.2013.0n49.
[10] P. Bayindir, R. P. Guillerman, M. J. Hicks, M. M. ChintagumpalaCellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy (2009), pp. 1066-1074, 10.1007/s00247-009-1348-9.
[11] Pachl M, Arul GS, Jester I, Bowen C, Hobin D, Morland B. Congenital mesoblastic nephroma: a single-centre series. Ann R Coll Surg Engl. 2020 Jan; 102 (1): 67-70. doi: 10.1308/rcsann.2019.0111. Epub 2019 Sep 11. PMID: 31508997; PMCID: PMC6937599.
[12] Zuo-Peng Wang, Kai Li, Kui-Ran Dong, Xian-Min Xiao, Shan ZhengCongenital mesoblastic nephroma: clinical analysis of eight cases and a review of the literature Oncol Lett, 8 (5) (2014 Nov), pp. 2007-2011.
Cite This Article
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    Karima Ryouni, Imane Ain El Hayat, Mouna Lehlimi, Amal Badre, Mounir Chemsi, et al. (2023). Congenital Mesoblastic Nephroma in a Newborn: Case Report. American Journal of Pediatrics, 9(1), 55-58. https://doi.org/10.11648/j.ajp.20230901.17

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    ACS Style

    Karima Ryouni; Imane Ain El Hayat; Mouna Lehlimi; Amal Badre; Mounir Chemsi, et al. Congenital Mesoblastic Nephroma in a Newborn: Case Report. Am. J. Pediatr. 2023, 9(1), 55-58. doi: 10.11648/j.ajp.20230901.17

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    AMA Style

    Karima Ryouni, Imane Ain El Hayat, Mouna Lehlimi, Amal Badre, Mounir Chemsi, et al. Congenital Mesoblastic Nephroma in a Newborn: Case Report. Am J Pediatr. 2023;9(1):55-58. doi: 10.11648/j.ajp.20230901.17

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  • @article{10.11648/j.ajp.20230901.17,
      author = {Karima Ryouni and Imane Ain El Hayat and Mouna Lehlimi and Amal Badre and Mounir Chemsi and Abdelhak Habzi and Said Benomar and Asmae El Kebir and Nisrine Bennani},
      title = {Congenital Mesoblastic Nephroma in a Newborn: Case Report},
      journal = {American Journal of Pediatrics},
      volume = {9},
      number = {1},
      pages = {55-58},
      doi = {10.11648/j.ajp.20230901.17},
      url = {https://doi.org/10.11648/j.ajp.20230901.17},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230901.17},
      abstract = {Background: Congenital mesoblastic nephroma (CMN) is a rare mesenchymal renal tumor of the newborn. The objective of this study was to review the clinical particularities, paraclinical and therapeutic characteristics of this tumor. It is about a case report of pediatric patient admitted to a Pediatric Neonatal Reanimation, A. Harouchi Hospital, Ibn Rochd university Hospital centre, Casablanca. Results: We report the observation of a 4-day premature newborn who was hospitalized for exploration of an abdominal mass occupying the right flank since birth. Abdominal ultrasonography revealed a predominantly fleshy right solidocystic renal mass, a site of calcifications laminating the cortex, measuring 57x33x58, with minimal pyelocaliceal dilatation and diffuse infiltration of perrenal fat. The CT scan revealed a kidney increased in size, seat of a voluminous mass rather well limited, of tissue density, heterogeneous, seat of necrosis, realizing a sign of the spur, measuring 40x47x58mm. The diagnosis was confirmed by a kidney biopsy. Conclusion: Mesoblastic nephroma is considered a benign tumor. The diagnosis is discussed on the basis of clinical data, ultrasound and CT scan. Surgery is the primary treatment for NMC and is based on extended nephrectomy. Most patients with NMC have a favorable outcome, the overall prognosis is very good.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Congenital Mesoblastic Nephroma in a Newborn: Case Report
    AU  - Karima Ryouni
    AU  - Imane Ain El Hayat
    AU  - Mouna Lehlimi
    AU  - Amal Badre
    AU  - Mounir Chemsi
    AU  - Abdelhak Habzi
    AU  - Said Benomar
    AU  - Asmae El Kebir
    AU  - Nisrine Bennani
    Y1  - 2023/03/31
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ajp.20230901.17
    DO  - 10.11648/j.ajp.20230901.17
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 55
    EP  - 58
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20230901.17
    AB  - Background: Congenital mesoblastic nephroma (CMN) is a rare mesenchymal renal tumor of the newborn. The objective of this study was to review the clinical particularities, paraclinical and therapeutic characteristics of this tumor. It is about a case report of pediatric patient admitted to a Pediatric Neonatal Reanimation, A. Harouchi Hospital, Ibn Rochd university Hospital centre, Casablanca. Results: We report the observation of a 4-day premature newborn who was hospitalized for exploration of an abdominal mass occupying the right flank since birth. Abdominal ultrasonography revealed a predominantly fleshy right solidocystic renal mass, a site of calcifications laminating the cortex, measuring 57x33x58, with minimal pyelocaliceal dilatation and diffuse infiltration of perrenal fat. The CT scan revealed a kidney increased in size, seat of a voluminous mass rather well limited, of tissue density, heterogeneous, seat of necrosis, realizing a sign of the spur, measuring 40x47x58mm. The diagnosis was confirmed by a kidney biopsy. Conclusion: Mesoblastic nephroma is considered a benign tumor. The diagnosis is discussed on the basis of clinical data, ultrasound and CT scan. Surgery is the primary treatment for NMC and is based on extended nephrectomy. Most patients with NMC have a favorable outcome, the overall prognosis is very good.
    VL  - 9
    IS  - 1
    ER  - 

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Author Information
  • Department of Neonatal Reanimation (P4), Children's Hospital A. Harouchi, Ibn Rochd University Hospital Centre, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco

  • Department of Neonatal Reanimation (P4), Children's Hospital A. Harouchi, Ibn Rochd University Hospital Centre, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco

  • Department of Neonatal Reanimation (P4), Children's Hospital A. Harouchi, Ibn Rochd University Hospital Centre, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco

  • Department of Neonatal Reanimation (P4), Children's Hospital A. Harouchi, Ibn Rochd University Hospital Centre, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco

  • Department of Neonatal Reanimation (P4), Children's Hospital A. Harouchi, Ibn Rochd University Hospital Centre, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco

  • Department of Neonatal Reanimation (P4), Children's Hospital A. Harouchi, Ibn Rochd University Hospital Centre, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco

  • Department of Neonatal Reanimation (P4), Children's Hospital A. Harouchi, Ibn Rochd University Hospital Centre, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco

  • Department of Anatomical Pathology, Ibn Rochd University Hospital Centre, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco

  • Department of Anatomical Pathology, Ibn Rochd University Hospital Centre, Hassan II University, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco

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