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Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh

Received: 8 October 2022     Accepted: 29 October 2022     Published: 10 November 2022
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Abstract

Objective: Early diagnosis of Persistent pulmonary hypertension of newborn is a challenge in developing countries. This study aimed to observe the association of Red Cell Distribution Width (RDW) in this critical condition of neonates. Method: This retrospective study was performed in Neonatology department of United Hospital Limited, Dhaka, over 5 years (2013 to 2017) where all PPHN cases were enrolled and compared with neonates without having PPHN. Pre-formed questionnaire was used to collect data. Baseline complete blood count was reviewed in all cases to see the mean Red Cell Distribution Width (RDW). Risk factors for developing persistent pulmonary hypertension was analyzed and cut off value of RDW was observed using Receiver-operating characteristics (ROC) curve. Result: A total of 157 cases were found with PPHN having male predominance (66%). Important risk factors for PPHN were maternal pregnancy induced hypertension and asthma. Respiratory Distress Syndrome and Meconium Aspiration Syndrome were strongly associated with PPHN. RDW was found higher in PPHN neonates than those in the control group (p <0.05). The cutoff point of RDW predictive of PPHN was 17.05 (with 85% sensitivity). Conclusion: Red Cell Distribution Width is an early predictor of persistent pulmonary hypertension of Newborn.

Published in American Journal of Pediatrics (Volume 8, Issue 4)
DOI 10.11648/j.ajp.20220804.18
Page(s) 239-243
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Persistent Fetal Circulation, RDW, Predictor, PPHN, Bangladesh

References
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    Nargis Ara Begum, Sharmin Afroze, Abrar Wahab, Runa Laila, Shahnaz Parvin Siddiqua, et al. (2022). Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh. American Journal of Pediatrics, 8(4), 239-243. https://doi.org/10.11648/j.ajp.20220804.18

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    ACS Style

    Nargis Ara Begum; Sharmin Afroze; Abrar Wahab; Runa Laila; Shahnaz Parvin Siddiqua, et al. Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh. Am. J. Pediatr. 2022, 8(4), 239-243. doi: 10.11648/j.ajp.20220804.18

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    AMA Style

    Nargis Ara Begum, Sharmin Afroze, Abrar Wahab, Runa Laila, Shahnaz Parvin Siddiqua, et al. Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh. Am J Pediatr. 2022;8(4):239-243. doi: 10.11648/j.ajp.20220804.18

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  • @article{10.11648/j.ajp.20220804.18,
      author = {Nargis Ara Begum and Sharmin Afroze and Abrar Wahab and Runa Laila and Shahnaz Parvin Siddiqua and Nurun Nahar Begum and Sabrina Khondoker Nila},
      title = {Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh},
      journal = {American Journal of Pediatrics},
      volume = {8},
      number = {4},
      pages = {239-243},
      doi = {10.11648/j.ajp.20220804.18},
      url = {https://doi.org/10.11648/j.ajp.20220804.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220804.18},
      abstract = {Objective: Early diagnosis of Persistent pulmonary hypertension of newborn is a challenge in developing countries. This study aimed to observe the association of Red Cell Distribution Width (RDW) in this critical condition of neonates. Method: This retrospective study was performed in Neonatology department of United Hospital Limited, Dhaka, over 5 years (2013 to 2017) where all PPHN cases were enrolled and compared with neonates without having PPHN. Pre-formed questionnaire was used to collect data. Baseline complete blood count was reviewed in all cases to see the mean Red Cell Distribution Width (RDW). Risk factors for developing persistent pulmonary hypertension was analyzed and cut off value of RDW was observed using Receiver-operating characteristics (ROC) curve. Result: A total of 157 cases were found with PPHN having male predominance (66%). Important risk factors for PPHN were maternal pregnancy induced hypertension and asthma. Respiratory Distress Syndrome and Meconium Aspiration Syndrome were strongly associated with PPHN. RDW was found higher in PPHN neonates than those in the control group (p <0.05). The cutoff point of RDW predictive of PPHN was 17.05 (with 85% sensitivity). Conclusion: Red Cell Distribution Width is an early predictor of persistent pulmonary hypertension of Newborn.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Red Cell Distribution Width (RDW) - An Early Predictor of Persistent Pulmonary Hypertension of Newborn (PPHN): A Comparative Study in Dhaka, Bangladesh
    AU  - Nargis Ara Begum
    AU  - Sharmin Afroze
    AU  - Abrar Wahab
    AU  - Runa Laila
    AU  - Shahnaz Parvin Siddiqua
    AU  - Nurun Nahar Begum
    AU  - Sabrina Khondoker Nila
    Y1  - 2022/11/10
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ajp.20220804.18
    DO  - 10.11648/j.ajp.20220804.18
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 239
    EP  - 243
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20220804.18
    AB  - Objective: Early diagnosis of Persistent pulmonary hypertension of newborn is a challenge in developing countries. This study aimed to observe the association of Red Cell Distribution Width (RDW) in this critical condition of neonates. Method: This retrospective study was performed in Neonatology department of United Hospital Limited, Dhaka, over 5 years (2013 to 2017) where all PPHN cases were enrolled and compared with neonates without having PPHN. Pre-formed questionnaire was used to collect data. Baseline complete blood count was reviewed in all cases to see the mean Red Cell Distribution Width (RDW). Risk factors for developing persistent pulmonary hypertension was analyzed and cut off value of RDW was observed using Receiver-operating characteristics (ROC) curve. Result: A total of 157 cases were found with PPHN having male predominance (66%). Important risk factors for PPHN were maternal pregnancy induced hypertension and asthma. Respiratory Distress Syndrome and Meconium Aspiration Syndrome were strongly associated with PPHN. RDW was found higher in PPHN neonates than those in the control group (p <0.05). The cutoff point of RDW predictive of PPHN was 17.05 (with 85% sensitivity). Conclusion: Red Cell Distribution Width is an early predictor of persistent pulmonary hypertension of Newborn.
    VL  - 8
    IS  - 4
    ER  - 

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Author Information
  • Department of Neonatology, United Hospital Limited, Dhaka, Bangladesh

  • Department of Neonatology, Dr. M R Khan Shishu Hospital & Institute of Child Health, Dhaka, Bangladesh

  • Department of Non-Communicable Disease and Mental Health, Center for Injury Prevention and Research, Dhaka, Bangladesh

  • Department of Neonatology, United Hospital Limited, Dhaka, Bangladesh

  • Department of Neonatology, United Hospital Limited, Dhaka, Bangladesh

  • Department of Neonatology, Sir Salimullah Medical College & Mitford Hospital, Dhaka, Bangladesh

  • Department of Neonatology, United Hospital Limited, Dhaka, Bangladesh

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