| Peer-Reviewed

Characteristics of Pseudomonas Aeruginosa Infection in Pediatric Patients Treated in Sanglah General Hospital Denpasar During Period February 2017 - May 2019

Received: 6 October 2020     Accepted: 17 October 2020     Published: 23 October 2020
Views:       Downloads:
Abstract

Health-care-associated infections is one of the causes of high mortality among inpatient children. Globally, prevalence nosocomial infection are 8.7%. In Indonesia, prevalence of nosocomial infection at 2014 are 148.703 cases. One of the Gram negative pathogen that has been known can cause nosocomial infection is Pseudomonas aeruginosa. This study aims to know patient characteristic with P. aeruginosa infection at Sanglah Hospital. This research is descriptive study with a cross-sectional approach conducted in Sanglah Hospital, Denpasar. The study used secondary data from medical records of pediatric patients who were proven to have P. aeruginosa infection through microbiological examination while undergoing treatment at Sanglah hospital in the period of Februari 2017- Mei 2019. Incomplete medical record data were excluded from the study. There were 30 children with positive blood culture P. aeruginosa. Most of them were male (17/30), with underlying disease pneumonia (13/30), length of stay before infection 16,8 days, total length of stay 28,5 day. Most patients died (19/30). 7 patients had history positive blood culture before P. aeruginosa infection. 29 patients using peripheral intravenous line (mean 22.5 day). Most patients were sensitive to Cefepime (80%) and resistant to Ampicilin Sulbactam (80%). Characteristic patients with Pseudomonas aeruginosa infection mostly were male, with underlying disease pneumonia, using medical device peripheral line, and died. Most of them were sensitive to Cefepime and resistant to Ampicilin Sulbactam.

Published in American Journal of Pediatrics (Volume 6, Issue 4)
DOI 10.11648/j.ajp.20200604.18
Page(s) 437-441
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Characteristic, Children, Health-care-Associated Infection, Pseudomonas aeruginosa Infection

References
[1] Bezadnia S, Davoudi A, Rezai M, Ahangarkani F. Nosocomial infections in Pediatric Population and Antibiotic Resistance of the Causative Organisme in North Iran. Iran Red Crescent Medical Journal. Vol 16, No. 2, 2014, pp. 145-62.
[2] Nugraheni, R. Suhartono. and Winarni, S. Infeksi Nosokomial di RSUD Setjonegoro Kabupaten Wonosobo. Media Kesehatan Masyarakat Indonesia. Vol. 11, No. 1, 2012, pp. 94–100.
[3] Noer, SF. Pola Bakteri Dan Resistensinya Terhadap Antibiotik Yang Ditemukan Pada Air Dan Udara Ruang Instalasi Rawat Khusus RSUP Dr. Wahidin Sudirohusodo Makassar. Majalah Farmasi dan Farmakologi. Vol 16, No. 2, 2012, pp. 73–78.
[4] Asi MH, Nateghian A. Epidemiology of nosocomial infections in a pediatric intensive care unit (PICU). Iranian Journal of Clinical Infectious Diseases. Vol. 4, No. 2, 2009, pp. 83-86.
[5] Taslim E, Maskoen TT. Pola Kuman Terbanyak Sebagai Agen Penyebab Infeksi di Intensive Care Unit pada Beberapa Rumah Sakit di Indonesia. Anesthesia & Critical Care. Vol. 34, 2016, pp. 56-62.
[6] El Zowalaty ME, Al Thani AA, Webster TJ, El Zowalaty AE, Schweizer HP, Nasrallah GK, et al. Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies. Future Microbiology. Vol. 10, No. 10, 2015, pp. 1683–706. Access from: http://dx.doi.org/10.2217/fmb.15.48.
[7] Bayani M, Siadati S, Rajabnia R, Taher AA. Drug Resistance of Pseudomonas aeruginosa and Enterobacter cloacae Isolated from ICU, Babol, Northern Iran. International Journal of Molecular Celular Medicine. Vol. 2, 2013, pp. 204–209.
[8] Falagas ME, Sideri G, Vouloumanou EK, Papadatos JH, Kafetzis DA Intravenous colistimethate (colistin) use in critically ill children without cystic fibrosis. Pediatric Infectious Disease Journal, Vol. 28, 2009, pp. 123–127.
[9] Folgori L, Livadiotti S, Carletti M, Bielicki J, Pontrelli G, Ciofi Degli Atti ML, et al. Epidemiology and clinical outcomes of multidrug-resistant, gram-negative bloodstream infections in a European tertiary pediatric hospital during a 12-month period. Pediatric Infectious Disease Journal. Vol. 33, 2014, pp. 929–932.
[10] Zhang Q, Smith JC, Zhu Q, Guo Z, MacDonald NE. A five-year review of Pseudomonas aeruginosa bacteremia in children hospitalized at a single center in southern China. International Journal Infectious Disease, Vol. 16, 2012, pp. 628–632.
[11] PengY, Bi J, Shi J, Li Y, Ye X, Chen X, et al. Multidrug-resistant Pseudomonas aeruginosa infections pose growing threat to healthcare-associated infection control in the hospitals of Southern China: a case-control surveillance study. American Journal of Infection Control, Vol. 42, 2014, pp. 1308–1311.
[12] Basseti M, Vena A, Croxatto A, Righi E, Guery B. How to Manage Pseudomonas aeruginosa infections. Drugs in Context. Vol. 7, 2018, pp. 1-18.
[13] Mayasari E. Pseudomonas aeruginosa; Karakteristik, Infeksi dan Penanganan. USU Repository. 2006.
[14] Saeed AH, Awad AA. Susceptibility of Pseudomonas aeruginosa to third generation Cephalosporins. Journal of Science and Technology, Vol. 10, No. 2, 2009, pp. 195-200.
[15] Choi Y, Paik JH, Kim JH, Han SB, Durey A. Clinical predictors of Pseudomonas aeruginosa Bacteremia in emergency department. Emergency medicine international. 2018, pp. 1-5. Access from: DOI: 10.1155/2018/7581036.
[16] Yang MA, Lee J, Choi EH, Lee HJ. Pseudomonas aeruginosa bacteremia in children over ten consecutive years: analysis of clinical characteristics, risk factor of multi-drug resistance and clinical outcomes. Journal of Korean Medical Science. Vo. 26, 2011, pp. 612-18. Access from: DOI: 10.3346/jkms.2011.26.5.612.
[17] Righi E, Peri AM, Harris PN, Wailan AM, Liborio M, Lane SW, et al. Global prevalence of carbapenem resistance in neutropenic patients and association with mortality and carbapenem use: systematic review and metaanalysis. Journal of Antimicrobial Chemotherapy. Vol. 72, No. 3, 2017, pp. 668–77. Access from: DOI: 10.1093/jac/dkw459.
[18] Gahlot R, Nigam C, Kumar V, Yadav G, Anupurba S. Catheter-related bloodstream infections. International Journal of Critical Illness and Injury Science. Vol. 4, 2014, pp. 162-8. Access from: DOI: 10.4103/2229-5151.134184.
[19] Tumbarello M, Repetto E, Trecarichi EM, Bernardini C, De Pascale G, Parisini A, dkk. Multidrug-resistant Pseudomonas aeruginosa bloodstreaminfections: risk factors and mortality. Epidemiology Infectious disease. Vol. 139, 2011, pp. 1740-9. Access from: DOI: 10.1017/S0950268810003055.
[20] Micek ST, Llyod AE, Ritchie DJ, Reichley RM, Fraser VJ, Kollef MH. Pseudomonas aeruginosa Bloodstream Infection: Importance of Appropriate Initial Antimicrobial Treatment. Antimicrobial, agents and chemotherapy. Vol. 49, No. 4, 2005, pp. 1306-11.
[21] Gasink LB, Fishman NO, Weiner MG, Nachamkin I, Bilker WB, Lautenbach E. Fluoroquinolone-resistant Pseudomonas aeruginosa assessment of risk factors and clinical impact. The American Journal of Medicine. Vol. 119, 2006, pp. 526. e19-25.
Cite This Article
  • APA Style

    Ida Ayu Putu Purnamawati, I Wayan Gustawan, I Made Gede Dwi Lingga Utama, Ni Made Adi Tarini. (2020). Characteristics of Pseudomonas Aeruginosa Infection in Pediatric Patients Treated in Sanglah General Hospital Denpasar During Period February 2017 - May 2019. American Journal of Pediatrics, 6(4), 437-441. https://doi.org/10.11648/j.ajp.20200604.18

    Copy | Download

    ACS Style

    Ida Ayu Putu Purnamawati; I Wayan Gustawan; I Made Gede Dwi Lingga Utama; Ni Made Adi Tarini. Characteristics of Pseudomonas Aeruginosa Infection in Pediatric Patients Treated in Sanglah General Hospital Denpasar During Period February 2017 - May 2019. Am. J. Pediatr. 2020, 6(4), 437-441. doi: 10.11648/j.ajp.20200604.18

    Copy | Download

    AMA Style

    Ida Ayu Putu Purnamawati, I Wayan Gustawan, I Made Gede Dwi Lingga Utama, Ni Made Adi Tarini. Characteristics of Pseudomonas Aeruginosa Infection in Pediatric Patients Treated in Sanglah General Hospital Denpasar During Period February 2017 - May 2019. Am J Pediatr. 2020;6(4):437-441. doi: 10.11648/j.ajp.20200604.18

    Copy | Download

  • @article{10.11648/j.ajp.20200604.18,
      author = {Ida Ayu Putu Purnamawati and I Wayan Gustawan and I Made Gede Dwi Lingga Utama and Ni Made Adi Tarini},
      title = {Characteristics of Pseudomonas Aeruginosa Infection in Pediatric Patients Treated in Sanglah General Hospital Denpasar During Period February 2017 - May 2019},
      journal = {American Journal of Pediatrics},
      volume = {6},
      number = {4},
      pages = {437-441},
      doi = {10.11648/j.ajp.20200604.18},
      url = {https://doi.org/10.11648/j.ajp.20200604.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200604.18},
      abstract = {Health-care-associated infections is one of the causes of high mortality among inpatient children. Globally, prevalence nosocomial infection are 8.7%. In Indonesia, prevalence of nosocomial infection at 2014 are 148.703 cases. One of the Gram negative pathogen that has been known can cause nosocomial infection is Pseudomonas aeruginosa. This study aims to know patient characteristic with P. aeruginosa infection at Sanglah Hospital. This research is descriptive study with a cross-sectional approach conducted in Sanglah Hospital, Denpasar. The study used secondary data from medical records of pediatric patients who were proven to have P. aeruginosa infection through microbiological examination while undergoing treatment at Sanglah hospital in the period of Februari 2017- Mei 2019. Incomplete medical record data were excluded from the study. There were 30 children with positive blood culture P. aeruginosa. Most of them were male (17/30), with underlying disease pneumonia (13/30), length of stay before infection 16,8 days, total length of stay 28,5 day. Most patients died (19/30). 7 patients had history positive blood culture before P. aeruginosa infection. 29 patients using peripheral intravenous line (mean 22.5 day). Most patients were sensitive to Cefepime (80%) and resistant to Ampicilin Sulbactam (80%). Characteristic patients with Pseudomonas aeruginosa infection mostly were male, with underlying disease pneumonia, using medical device peripheral line, and died. Most of them were sensitive to Cefepime and resistant to Ampicilin Sulbactam.},
     year = {2020}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Characteristics of Pseudomonas Aeruginosa Infection in Pediatric Patients Treated in Sanglah General Hospital Denpasar During Period February 2017 - May 2019
    AU  - Ida Ayu Putu Purnamawati
    AU  - I Wayan Gustawan
    AU  - I Made Gede Dwi Lingga Utama
    AU  - Ni Made Adi Tarini
    Y1  - 2020/10/23
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ajp.20200604.18
    DO  - 10.11648/j.ajp.20200604.18
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 437
    EP  - 441
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20200604.18
    AB  - Health-care-associated infections is one of the causes of high mortality among inpatient children. Globally, prevalence nosocomial infection are 8.7%. In Indonesia, prevalence of nosocomial infection at 2014 are 148.703 cases. One of the Gram negative pathogen that has been known can cause nosocomial infection is Pseudomonas aeruginosa. This study aims to know patient characteristic with P. aeruginosa infection at Sanglah Hospital. This research is descriptive study with a cross-sectional approach conducted in Sanglah Hospital, Denpasar. The study used secondary data from medical records of pediatric patients who were proven to have P. aeruginosa infection through microbiological examination while undergoing treatment at Sanglah hospital in the period of Februari 2017- Mei 2019. Incomplete medical record data were excluded from the study. There were 30 children with positive blood culture P. aeruginosa. Most of them were male (17/30), with underlying disease pneumonia (13/30), length of stay before infection 16,8 days, total length of stay 28,5 day. Most patients died (19/30). 7 patients had history positive blood culture before P. aeruginosa infection. 29 patients using peripheral intravenous line (mean 22.5 day). Most patients were sensitive to Cefepime (80%) and resistant to Ampicilin Sulbactam (80%). Characteristic patients with Pseudomonas aeruginosa infection mostly were male, with underlying disease pneumonia, using medical device peripheral line, and died. Most of them were sensitive to Cefepime and resistant to Ampicilin Sulbactam.
    VL  - 6
    IS  - 4
    ER  - 

    Copy | Download

Author Information
  • Department of Child Health, Medical Faculty of Udayana University, Sanglah Hospital, Denpasar, Indonesia

  • Department of Child Health, Medical Faculty of Udayana University, Sanglah Hospital, Denpasar, Indonesia

  • Department of Child Health, Medical Faculty of Udayana University, Sanglah Hospital, Denpasar, Indonesia

  • Department of Clinical Microbiology, Medical Faculty of Udayana University, Sanglah Hospital, Denpasar, Indonesia

  • Sections