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Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants

Received: 27 July 2020     Accepted: 10 August 2020     Published: 18 August 2020
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Abstract

IL-6 is thought to be involved in the prognosis of extremely low birth weight infants, in whom it leads to newborn organopathy. IL-6 also influences various processes in vivo, including thrombocytopoiesis. In the present study, we investigated whether the influence of IL-6 in the fetal period could be evaluated using the actual number of infant platelets, which is an index of thrombocytopoiesis. We retrospectively examined the perinatal information of extremely low birth weight infants, IL-6, the number of platelets (Plt), and the number of immature platelets fraction (IPF). The study population included 81 infants. The mean gestational age of the infants was 26.1±2.5 weeks and the mean birth weight was 729±161 g. The immature platelet count (Plt×IPF) was positively correlated with the IgM level (R=0.45, p<0.01) and the membrane rupture time (R=0.095, p<0.01). In addition, the Plt×IPF in the group in which the cord blood IL-6 level was ≥11 pg/mL was significantly higher than that in the group in which the cord blood IL-6 was <11 pg/mL (p<0.01). The Plt×IPF value at birth was associated with the IL-6 level in extremely low birth weight infants, which suggests the possibility that it may be used to evaluate fetal inflammation.

Published in American Journal of Pediatrics (Volume 6, Issue 3)
DOI 10.11648/j.ajp.20200603.37
Page(s) 334-340
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Extra-low Birth Weight Infants, Platelet Count, Immature Platelet Fraction, Chorioamnionitis, Fetal Inflammatory Response Syndrome (FIRS)

References
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Cite This Article
  • APA Style

    Yuko Sakurai, Motoichiro Sakurai. (2020). Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants. American Journal of Pediatrics, 6(3), 334-340. https://doi.org/10.11648/j.ajp.20200603.37

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    ACS Style

    Yuko Sakurai; Motoichiro Sakurai. Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants. Am. J. Pediatr. 2020, 6(3), 334-340. doi: 10.11648/j.ajp.20200603.37

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    AMA Style

    Yuko Sakurai, Motoichiro Sakurai. Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants. Am J Pediatr. 2020;6(3):334-340. doi: 10.11648/j.ajp.20200603.37

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  • @article{10.11648/j.ajp.20200603.37,
      author = {Yuko Sakurai and Motoichiro Sakurai},
      title = {Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants},
      journal = {American Journal of Pediatrics},
      volume = {6},
      number = {3},
      pages = {334-340},
      doi = {10.11648/j.ajp.20200603.37},
      url = {https://doi.org/10.11648/j.ajp.20200603.37},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200603.37},
      abstract = {IL-6 is thought to be involved in the prognosis of extremely low birth weight infants, in whom it leads to newborn organopathy. IL-6 also influences various processes in vivo, including thrombocytopoiesis. In the present study, we investigated whether the influence of IL-6 in the fetal period could be evaluated using the actual number of infant platelets, which is an index of thrombocytopoiesis. We retrospectively examined the perinatal information of extremely low birth weight infants, IL-6, the number of platelets (Plt), and the number of immature platelets fraction (IPF). The study population included 81 infants. The mean gestational age of the infants was 26.1±2.5 weeks and the mean birth weight was 729±161 g. The immature platelet count (Plt×IPF) was positively correlated with the IgM level (R=0.45, p<0.01) and the membrane rupture time (R=0.095, p<0.01). In addition, the Plt×IPF in the group in which the cord blood IL-6 level was ≥11 pg/mL was significantly higher than that in the group in which the cord blood IL-6 was <11 pg/mL (p<0.01). The Plt×IPF value at birth was associated with the IL-6 level in extremely low birth weight infants, which suggests the possibility that it may be used to evaluate fetal inflammation.},
     year = {2020}
    }
    

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    T1  - Examination of Intrauterine Inflammation and Immature Platelet Fraction at Birth in Extremely Low Birth Weight Infants
    AU  - Yuko Sakurai
    AU  - Motoichiro Sakurai
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    DO  - 10.11648/j.ajp.20200603.37
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
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    PB  - Science Publishing Group
    SN  - 2472-0909
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    AB  - IL-6 is thought to be involved in the prognosis of extremely low birth weight infants, in whom it leads to newborn organopathy. IL-6 also influences various processes in vivo, including thrombocytopoiesis. In the present study, we investigated whether the influence of IL-6 in the fetal period could be evaluated using the actual number of infant platelets, which is an index of thrombocytopoiesis. We retrospectively examined the perinatal information of extremely low birth weight infants, IL-6, the number of platelets (Plt), and the number of immature platelets fraction (IPF). The study population included 81 infants. The mean gestational age of the infants was 26.1±2.5 weeks and the mean birth weight was 729±161 g. The immature platelet count (Plt×IPF) was positively correlated with the IgM level (R=0.45, p<0.01) and the membrane rupture time (R=0.095, p<0.01). In addition, the Plt×IPF in the group in which the cord blood IL-6 level was ≥11 pg/mL was significantly higher than that in the group in which the cord blood IL-6 was <11 pg/mL (p<0.01). The Plt×IPF value at birth was associated with the IL-6 level in extremely low birth weight infants, which suggests the possibility that it may be used to evaluate fetal inflammation.
    VL  - 6
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Author Information
  • Division of Neonatology, Showa University Koto Toyosu Hospital, Tokyo, Japan

  • Division of Neonatology, Showa University Koto Toyosu Hospital, Tokyo, Japan

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