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Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon

Received: 13 January 2020     Accepted: 27 January 2020     Published: 23 November 2020
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Abstract

Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in inflammatory bowel diseases. The present study was designed to evaluate the effect of feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus on acetic acid-induced inflammation in mouse colon. Inflammatory model that mimics various features of IBDs was induced by a single application of 100µl of 4.5% acetic acid in Swiss Albino mice. Mice were pretreated orally by 200µl yogurt containing both L. acidophilus and L. bulgaricus for 3 days before induction of inflammation and 200µl yogurt was given orally for a period of 7 days after acetic-acid induction. The body weight, food and water intakes, serum biomarkers, macroscopic and histopathological studies of colon tissues were performed to evaluate the anti-inflammatory effect. Combined administration of both strains prevented the damages of villous and crypts in colon epithelial cells and thus provides unique mucosal protective effects in experimental colitis. In conclusion, feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus prevented or ameliorated the inflammatory conditions that can be beneficial to prevent or lower risks of IBDs and its complications.

Published in American Journal of Life Sciences (Volume 8, Issue 6)
DOI 10.11648/j.ajls.20200806.11
Page(s) 183-188
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Probiotics, Inflammatory Bowel Diseases, Acetic Acid-induced Inflammation

References
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Cite This Article
  • APA Style

    Md Shihab Uddin Sohag, Mst. Mahfuza Rahman, Mollika Paul, Md. Masud Rana, Ranjan Kumar Barman, et al. (2020). Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon. American Journal of Life Sciences, 8(6), 183-188. https://doi.org/10.11648/j.ajls.20200806.11

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    ACS Style

    Md Shihab Uddin Sohag; Mst. Mahfuza Rahman; Mollika Paul; Md. Masud Rana; Ranjan Kumar Barman, et al. Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon. Am. J. Life Sci. 2020, 8(6), 183-188. doi: 10.11648/j.ajls.20200806.11

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    AMA Style

    Md Shihab Uddin Sohag, Mst. Mahfuza Rahman, Mollika Paul, Md. Masud Rana, Ranjan Kumar Barman, et al. Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon. Am J Life Sci. 2020;8(6):183-188. doi: 10.11648/j.ajls.20200806.11

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  • @article{10.11648/j.ajls.20200806.11,
      author = {Md Shihab Uddin Sohag and Mst. Mahfuza Rahman and Mollika Paul and Md. Masud Rana and Ranjan Kumar Barman and Mir Imam Ibne Wahed and Md. Rafiqul Islam Khan},
      title = {Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon},
      journal = {American Journal of Life Sciences},
      volume = {8},
      number = {6},
      pages = {183-188},
      doi = {10.11648/j.ajls.20200806.11},
      url = {https://doi.org/10.11648/j.ajls.20200806.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20200806.11},
      abstract = {Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in inflammatory bowel diseases. The present study was designed to evaluate the effect of feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus on acetic acid-induced inflammation in mouse colon. Inflammatory model that mimics various features of IBDs was induced by a single application of 100µl of 4.5% acetic acid in Swiss Albino mice. Mice were pretreated orally by 200µl yogurt containing both L. acidophilus and L. bulgaricus for 3 days before induction of inflammation and 200µl yogurt was given orally for a period of 7 days after acetic-acid induction. The body weight, food and water intakes, serum biomarkers, macroscopic and histopathological studies of colon tissues were performed to evaluate the anti-inflammatory effect. Combined administration of both strains prevented the damages of villous and crypts in colon epithelial cells and thus provides unique mucosal protective effects in experimental colitis. In conclusion, feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus prevented or ameliorated the inflammatory conditions that can be beneficial to prevent or lower risks of IBDs and its complications.},
     year = {2020}
    }
    

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    T1  - Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon
    AU  - Md Shihab Uddin Sohag
    AU  - Mst. Mahfuza Rahman
    AU  - Mollika Paul
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    AU  - Ranjan Kumar Barman
    AU  - Mir Imam Ibne Wahed
    AU  - Md. Rafiqul Islam Khan
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    DO  - 10.11648/j.ajls.20200806.11
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
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    EP  - 188
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20200806.11
    AB  - Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in inflammatory bowel diseases. The present study was designed to evaluate the effect of feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus on acetic acid-induced inflammation in mouse colon. Inflammatory model that mimics various features of IBDs was induced by a single application of 100µl of 4.5% acetic acid in Swiss Albino mice. Mice were pretreated orally by 200µl yogurt containing both L. acidophilus and L. bulgaricus for 3 days before induction of inflammation and 200µl yogurt was given orally for a period of 7 days after acetic-acid induction. The body weight, food and water intakes, serum biomarkers, macroscopic and histopathological studies of colon tissues were performed to evaluate the anti-inflammatory effect. Combined administration of both strains prevented the damages of villous and crypts in colon epithelial cells and thus provides unique mucosal protective effects in experimental colitis. In conclusion, feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus prevented or ameliorated the inflammatory conditions that can be beneficial to prevent or lower risks of IBDs and its complications.
    VL  - 8
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Author Information
  • Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh

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