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A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India

Received: 31 March 2021     Accepted: 19 April 2021     Published: 29 April 2021
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Abstract

Association between ABO blood group and rheumatic diseases is not well characterized. This study assessed distribution of ABO blood group and Rh factor in patients with rheumatic diseases and healthy blood donors. We retrospectively evaluated data of patients with rheumatic diseases who attended the hospital from September 2015 to January 2020, and the documented evidence of blood group of healthy blood donors. Data from 5000 healthy donors and 3165 patients with rheumatic disease were assessed. Overall, blood type O was the most prevalent (42.94% and 43.14%) followed by B (33.21% and 30.08%), A (17.66% and 21.48%) and AB (6.19% and 5.30%) in patients with rheumatic disease and healthy donors, respectively. This distribution was statistically different between the groups, with blood group A being more common in healthy donors than in patients with rheumatic disease (P<0.0001). Distribution of ABO groups among rheumatic disease types was similar (P=0.2921). More individuals had Rhesus (Rh) (+) factor (93.97%) than Rh (-) (6.03%), however, its distribution was comparable across healthy donors and patients with rheumatic disease (P=0.1145). Patients with blood group A had significantly lower risk of developing rheumatic diseases compared to blood group O (OR [95% CI]: 0.94 [0.780, 1.134]; P<0.0318). Similarly, patients bearing blood type A+ (0.98 [0.62, 1.54]; P=0.0037) and O+ (1.08 [0.694, 1.68]; P=0.0215) were at a lower risk for developing rheumatic diseases compared to those with O- blood group. The most common blood type was O followed by B, A and AB in patients with rheumatic disease and healthy donors. Individuals with blood group A had lower risk of developing rheumatic diseases compared to other blood types.

Published in American Journal of Internal Medicine (Volume 9, Issue 3)
DOI 10.11648/j.ajim.20210903.11
Page(s) 107-113
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

ABO Blood-group System, Blood Donors, Blood Groups, Rheumatic Diseases

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    Arindam Nandy Roy, Yarram Ashok Kumar, Regina Lata Thadigiri. (2021). A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India. American Journal of Internal Medicine, 9(3), 107-113. https://doi.org/10.11648/j.ajim.20210903.11

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    ACS Style

    Arindam Nandy Roy; Yarram Ashok Kumar; Regina Lata Thadigiri. A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India. Am. J. Intern. Med. 2021, 9(3), 107-113. doi: 10.11648/j.ajim.20210903.11

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    AMA Style

    Arindam Nandy Roy, Yarram Ashok Kumar, Regina Lata Thadigiri. A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India. Am J Intern Med. 2021;9(3):107-113. doi: 10.11648/j.ajim.20210903.11

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  • @article{10.11648/j.ajim.20210903.11,
      author = {Arindam Nandy Roy and Yarram Ashok Kumar and Regina Lata Thadigiri},
      title = {A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India},
      journal = {American Journal of Internal Medicine},
      volume = {9},
      number = {3},
      pages = {107-113},
      doi = {10.11648/j.ajim.20210903.11},
      url = {https://doi.org/10.11648/j.ajim.20210903.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20210903.11},
      abstract = {Association between ABO blood group and rheumatic diseases is not well characterized. This study assessed distribution of ABO blood group and Rh factor in patients with rheumatic diseases and healthy blood donors. We retrospectively evaluated data of patients with rheumatic diseases who attended the hospital from September 2015 to January 2020, and the documented evidence of blood group of healthy blood donors. Data from 5000 healthy donors and 3165 patients with rheumatic disease were assessed. Overall, blood type O was the most prevalent (42.94% and 43.14%) followed by B (33.21% and 30.08%), A (17.66% and 21.48%) and AB (6.19% and 5.30%) in patients with rheumatic disease and healthy donors, respectively. This distribution was statistically different between the groups, with blood group A being more common in healthy donors than in patients with rheumatic disease (PP=0.2921). More individuals had Rhesus (Rh) (+) factor (93.97%) than Rh (-) (6.03%), however, its distribution was comparable across healthy donors and patients with rheumatic disease (P=0.1145). Patients with blood group A had significantly lower risk of developing rheumatic diseases compared to blood group O (OR [95% CI]: 0.94 [0.780, 1.134]; PP=0.0037) and O+ (1.08 [0.694, 1.68]; P=0.0215) were at a lower risk for developing rheumatic diseases compared to those with O- blood group. The most common blood type was O followed by B, A and AB in patients with rheumatic disease and healthy donors. Individuals with blood group A had lower risk of developing rheumatic diseases compared to other blood types.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - A Retrospective Observational Study Comparing ABO Blood Group and Rh Factor Distribution in Patients with Rheumatic Diseases and Healthy Donors in Southern India
    AU  - Arindam Nandy Roy
    AU  - Yarram Ashok Kumar
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    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20210903.11
    AB  - Association between ABO blood group and rheumatic diseases is not well characterized. This study assessed distribution of ABO blood group and Rh factor in patients with rheumatic diseases and healthy blood donors. We retrospectively evaluated data of patients with rheumatic diseases who attended the hospital from September 2015 to January 2020, and the documented evidence of blood group of healthy blood donors. Data from 5000 healthy donors and 3165 patients with rheumatic disease were assessed. Overall, blood type O was the most prevalent (42.94% and 43.14%) followed by B (33.21% and 30.08%), A (17.66% and 21.48%) and AB (6.19% and 5.30%) in patients with rheumatic disease and healthy donors, respectively. This distribution was statistically different between the groups, with blood group A being more common in healthy donors than in patients with rheumatic disease (PP=0.2921). More individuals had Rhesus (Rh) (+) factor (93.97%) than Rh (-) (6.03%), however, its distribution was comparable across healthy donors and patients with rheumatic disease (P=0.1145). Patients with blood group A had significantly lower risk of developing rheumatic diseases compared to blood group O (OR [95% CI]: 0.94 [0.780, 1.134]; PP=0.0037) and O+ (1.08 [0.694, 1.68]; P=0.0215) were at a lower risk for developing rheumatic diseases compared to those with O- blood group. The most common blood type was O followed by B, A and AB in patients with rheumatic disease and healthy donors. Individuals with blood group A had lower risk of developing rheumatic diseases compared to other blood types.
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Author Information
  • Department of Rheumatology, Yashoda Hospital, Telangana, India

  • Department of Rheumatology, Yashoda Hospital, Telangana, India

  • Department of Rheumatology, Yashoda Hospital, Telangana, India

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