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Secondary Mesenteric Panniculitis as a Paraneoplastic Syndrome: An Updated Review

Received: 12 August 2019     Accepted: 6 September 2019     Published: 24 October 2019
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Abstract

In response to the case of a patient with mesenteric panniculitis (MP) and proliferative disease, we reviewed the literature on their possible association and associations with other neoplasms. MP is a non-specific chronic inflammation of the mesenteric fat, with low prevalence and unknown etiology; patients may be asymptomatic or present predominantly gastrointestinal complaints. The disease can be either primary or secondary to other pathologies, including neoplastic ones. Diagnosis is made via computed tomography (CT) and confirmed by biopsy. Currently, there is no established treatment for MP. The literature contains series of variable sample sizes, case reports, reviews of other published studies, and some series after a 5-year follow-up. Papers tend to be relatively consistent when it comes to prevalence data and clinical manifestations. However, there is still controversy regarding the role that secondary MP could play in a paraneoplastic picture. From the diagnostic point of view, the incorporation and use of positron emission tomography (PET), together with CT, has been helpful for the approach and the diagnostic focus in this field. Nevertheless, its usage and the discrimination cut point between inflammatory pathology and tumor pathology (maximum standard uptake value: SUVmax) are not clearly defined in neoplastic cases.

Published in American Journal of Internal Medicine (Volume 7, Issue 6)
DOI 10.11648/j.ajim.20190706.11
Page(s) 141-146
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Mesenteric Panniculitis, Abdominal Mass, Paraneoplastic Phenomenon, CT, PET/CT

References
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[4] Scheer F et al. Mesenteric Panniculitis (MP) in CT – A Predictor of Malignancy? Fortschr Röntgenstr. 2016; 188: 926-932.
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[19] Khasminsky V, Ram E, Atar E. et al. Is there an association between mesenteric panniculitis and lymphoma? A case control analysis. Clin Radiol 2017; 72 (10): 844-849.
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[21] Orcajo Rincón, J., Rotger Regi, A., Mari Hualde, A., Reguera Berenguer, L., Hernandez Moreno, L. y Alonso Farto, J. A prospective study to determine the real value of mesenteric 18F-FDG uptake in cancer patients. inflammatory or tumoral mesenteric paniculitis? Rev Esp Med Nucl Imagen Mol. 2014; 33 (6): 352-357.
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Cite This Article
  • APA Style

    Mónica García-Fernández, María Dolores Jover-Ríos, Pedro Esteve-Atiénzar, Juan Méndez-Mora, Alex Méndez-Jover, et al. (2019). Secondary Mesenteric Panniculitis as a Paraneoplastic Syndrome: An Updated Review. American Journal of Internal Medicine, 7(6), 141-146. https://doi.org/10.11648/j.ajim.20190706.11

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    ACS Style

    Mónica García-Fernández; María Dolores Jover-Ríos; Pedro Esteve-Atiénzar; Juan Méndez-Mora; Alex Méndez-Jover, et al. Secondary Mesenteric Panniculitis as a Paraneoplastic Syndrome: An Updated Review. Am. J. Intern. Med. 2019, 7(6), 141-146. doi: 10.11648/j.ajim.20190706.11

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    AMA Style

    Mónica García-Fernández, María Dolores Jover-Ríos, Pedro Esteve-Atiénzar, Juan Méndez-Mora, Alex Méndez-Jover, et al. Secondary Mesenteric Panniculitis as a Paraneoplastic Syndrome: An Updated Review. Am J Intern Med. 2019;7(6):141-146. doi: 10.11648/j.ajim.20190706.11

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  • @article{10.11648/j.ajim.20190706.11,
      author = {Mónica García-Fernández and María Dolores Jover-Ríos and Pedro Esteve-Atiénzar and Juan Méndez-Mora and Alex Méndez-Jover and Sonia Cascant-Pérez and Francisco Caparrós-Hernández and Carmen Seguí-Pérez and Marc Seguí-Pérez and Lidia Ramírez-Utrero and Carles García-Cervera and Juan Manuel Núñez-Cruz and David Bonet-Tur and Sara Bañón-Escandell and Pablo Roig-Rico and Jorge Peris-García and Asunción Pérez-Fullana and José Miguel Seguí-Ripoll},
      title = {Secondary Mesenteric Panniculitis as a Paraneoplastic Syndrome: An Updated Review},
      journal = {American Journal of Internal Medicine},
      volume = {7},
      number = {6},
      pages = {141-146},
      doi = {10.11648/j.ajim.20190706.11},
      url = {https://doi.org/10.11648/j.ajim.20190706.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20190706.11},
      abstract = {In response to the case of a patient with mesenteric panniculitis (MP) and proliferative disease, we reviewed the literature on their possible association and associations with other neoplasms. MP is a non-specific chronic inflammation of the mesenteric fat, with low prevalence and unknown etiology; patients may be asymptomatic or present predominantly gastrointestinal complaints. The disease can be either primary or secondary to other pathologies, including neoplastic ones. Diagnosis is made via computed tomography (CT) and confirmed by biopsy. Currently, there is no established treatment for MP. The literature contains series of variable sample sizes, case reports, reviews of other published studies, and some series after a 5-year follow-up. Papers tend to be relatively consistent when it comes to prevalence data and clinical manifestations. However, there is still controversy regarding the role that secondary MP could play in a paraneoplastic picture. From the diagnostic point of view, the incorporation and use of positron emission tomography (PET), together with CT, has been helpful for the approach and the diagnostic focus in this field. Nevertheless, its usage and the discrimination cut point between inflammatory pathology and tumor pathology (maximum standard uptake value: SUVmax) are not clearly defined in neoplastic cases.},
     year = {2019}
    }
    

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    T1  - Secondary Mesenteric Panniculitis as a Paraneoplastic Syndrome: An Updated Review
    AU  - Mónica García-Fernández
    AU  - María Dolores Jover-Ríos
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    AU  - Juan Méndez-Mora
    AU  - Alex Méndez-Jover
    AU  - Sonia Cascant-Pérez
    AU  - Francisco Caparrós-Hernández
    AU  - Carmen Seguí-Pérez
    AU  - Marc Seguí-Pérez
    AU  - Lidia Ramírez-Utrero
    AU  - Carles García-Cervera
    AU  - Juan Manuel Núñez-Cruz
    AU  - David Bonet-Tur
    AU  - Sara Bañón-Escandell
    AU  - Pablo Roig-Rico
    AU  - Jorge Peris-García
    AU  - Asunción Pérez-Fullana
    AU  - José Miguel Seguí-Ripoll
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    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
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    EP  - 146
    PB  - Science Publishing Group
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    AB  - In response to the case of a patient with mesenteric panniculitis (MP) and proliferative disease, we reviewed the literature on their possible association and associations with other neoplasms. MP is a non-specific chronic inflammation of the mesenteric fat, with low prevalence and unknown etiology; patients may be asymptomatic or present predominantly gastrointestinal complaints. The disease can be either primary or secondary to other pathologies, including neoplastic ones. Diagnosis is made via computed tomography (CT) and confirmed by biopsy. Currently, there is no established treatment for MP. The literature contains series of variable sample sizes, case reports, reviews of other published studies, and some series after a 5-year follow-up. Papers tend to be relatively consistent when it comes to prevalence data and clinical manifestations. However, there is still controversy regarding the role that secondary MP could play in a paraneoplastic picture. From the diagnostic point of view, the incorporation and use of positron emission tomography (PET), together with CT, has been helpful for the approach and the diagnostic focus in this field. Nevertheless, its usage and the discrimination cut point between inflammatory pathology and tumor pathology (maximum standard uptake value: SUVmax) are not clearly defined in neoplastic cases.
    VL  - 7
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Author Information
  • Faculty of Medicine, Miguel Hernández University, Elche, Spain

  • Department of Internal Medicine, Hospital La Vega Baja of Orihuela, Alicante, Spain

  • Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain

  • Department of English, Marist Brothers High School, Alicante, Spain

  • Department of English, Marist Brothers High School, Alicante, Spain

  • Primary Medicine, Hospital Francesc Borgia of Gandía, Valencia, Spain

  • Department of English, Marist Brothers High School, Alicante, Spain

  • Department of English, Marist Brothers High School, Alicante, Spain

  • Department of English, Marist Brothers High School, Alicante, Spain

  • Primary Medicine, University Hospital of San Juan, Alicante, Spain

  • Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain

  • Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain

  • Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain

  • Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain

  • Department of English, Marist Brothers High School, Alicante, Spain

  • Department of Internal Medicine, University Hospital of San Juan, Alicante, Spain

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