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Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes

Received: 31 May 2015     Accepted: 9 June 2015     Published: 25 June 2015
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Abstract

Background: Glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2 hours (2-hr) after breakfast (ABF) plasma glucose, are often used to monitor and manage glycemia in stable diabetic patients. Data regarding the relationship and relative contribution of FPG and 2-hr ABF plasma glucose to HbA1c level in Type 2 diabetes mellitus (T2DM) are insufficient. Objective: To examine the correlation of FPG, and 2-hr ABF with HbA1c in known patients having T2DM; and to find out which one of FPG and ABF is the dominant contributor to overall glycemia in monitoring diabetes. Study Design and Methods: The study was carried on 664 known T2DM patients under treatment and routine follow-up at a tertiary care hospital in Bangladesh. FPG & 2-hr ABF plasma glucose concentrations were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography based hemoglobin assay system. The Pearson correlation coefficient was used to investigate the relationship of FPG and ABF with HbA1c and their significance. Results: Both FPG and ABF levels were correlated with HbA1c but higher correlation was seen between FPG and HbA1c. The correlation coefficients between FPG and HbA1c and between ABF and HbA1c were 0.722 and 0.664 respectively. Both the correlations were found statistically significant (p<0.001). Conclusion: In patients with T2DM, FPG and ABF both were significantly correlated with HbA1c; and in our study we found that overall correlation of HbA1c with FPG was higher than ABF plasma glucose level.

Published in American Journal of Internal Medicine (Volume 3, Issue 4)
DOI 10.11648/j.ajim.20150304.13
Page(s) 160-164
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Glycosylated Hemoglobin, Fasting Plasma Glucose, 2 Hours After Breakfast, Diabetes Mellitus

References
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[6] Stratton IM, Adler AI, Neil HAW, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321:405–12.
[7] Handelsman Y, Mechanick JI, Blonde L, Grunberger G, Bloomgarden ZT, Bray GA,, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for Developing a Diabetes Mellitus Comprehensive Care Plan. Endocr Pract 2011;17(Suppl 2):1-53
[8] Diabetes Control and Complications Trial Research Group, ‘The effect of intensive treatment of diabetes on development and progression of long term complications in insulin dependent diabetes mellitus’, N Engl J Med 1993;329:977-86.
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[14] Gupta S, Puppalwar PV, Chalak A. Correlation of fasting and post meal plasma glucose level to increased HbA1c levels in type-2 diabetes mellitus. Int J Adv Med 2014;1:127-31.
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Cite This Article
  • APA Style

    Sheikh Salahuddin Ahmed, Tarafdar Runa Laila, Fazle Nur, Mamun Ul Islam Khan, Umme Sadia Mili, et al. (2015). Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes. American Journal of Internal Medicine, 3(4), 160-164. https://doi.org/10.11648/j.ajim.20150304.13

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    ACS Style

    Sheikh Salahuddin Ahmed; Tarafdar Runa Laila; Fazle Nur; Mamun Ul Islam Khan; Umme Sadia Mili, et al. Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes. Am. J. Intern. Med. 2015, 3(4), 160-164. doi: 10.11648/j.ajim.20150304.13

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    AMA Style

    Sheikh Salahuddin Ahmed, Tarafdar Runa Laila, Fazle Nur, Mamun Ul Islam Khan, Umme Sadia Mili, et al. Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes. Am J Intern Med. 2015;3(4):160-164. doi: 10.11648/j.ajim.20150304.13

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  • @article{10.11648/j.ajim.20150304.13,
      author = {Sheikh Salahuddin Ahmed and Tarafdar Runa Laila and Fazle Nur and Mamun Ul Islam Khan and Umme Sadia Mili and Md. Abdul Mahid Khan and Mohammad Rafiqul Hoque},
      title = {Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes},
      journal = {American Journal of Internal Medicine},
      volume = {3},
      number = {4},
      pages = {160-164},
      doi = {10.11648/j.ajim.20150304.13},
      url = {https://doi.org/10.11648/j.ajim.20150304.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150304.13},
      abstract = {Background: Glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2 hours (2-hr) after breakfast (ABF) plasma glucose, are often used to monitor and manage glycemia in stable diabetic patients. Data regarding the relationship and relative contribution of FPG and 2-hr ABF plasma glucose to HbA1c level in Type 2 diabetes mellitus (T2DM) are insufficient. Objective: To examine the correlation of FPG, and 2-hr ABF with HbA1c in known patients having T2DM; and to find out which one of FPG and ABF is the dominant contributor to overall glycemia in monitoring diabetes. Study Design and Methods: The study was carried on 664 known T2DM patients under treatment and routine follow-up at a tertiary care hospital in Bangladesh. FPG & 2-hr ABF plasma glucose concentrations were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography based hemoglobin assay system. The Pearson correlation coefficient was used to investigate the relationship of FPG and ABF with HbA1c and their significance. Results: Both FPG and ABF levels were correlated with HbA1c but higher correlation was seen between FPG and HbA1c. The correlation coefficients between FPG and HbA1c and between ABF and HbA1c were 0.722 and 0.664 respectively. Both the correlations were found statistically significant (p<0.001). Conclusion: In patients with T2DM, FPG and ABF both were significantly correlated with HbA1c; and in our study we found that overall correlation of HbA1c with FPG was higher than ABF plasma glucose level.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Relationship of Glycosylated Hemoglobin with Fasting Plasma Glucose and 2 Hours After Breakfast Plasma Glucose in Type 2 Diabetes
    AU  - Sheikh Salahuddin Ahmed
    AU  - Tarafdar Runa Laila
    AU  - Fazle Nur
    AU  - Mamun Ul Islam Khan
    AU  - Umme Sadia Mili
    AU  - Md. Abdul Mahid Khan
    AU  - Mohammad Rafiqul Hoque
    Y1  - 2015/06/25
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajim.20150304.13
    DO  - 10.11648/j.ajim.20150304.13
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 160
    EP  - 164
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20150304.13
    AB  - Background: Glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2 hours (2-hr) after breakfast (ABF) plasma glucose, are often used to monitor and manage glycemia in stable diabetic patients. Data regarding the relationship and relative contribution of FPG and 2-hr ABF plasma glucose to HbA1c level in Type 2 diabetes mellitus (T2DM) are insufficient. Objective: To examine the correlation of FPG, and 2-hr ABF with HbA1c in known patients having T2DM; and to find out which one of FPG and ABF is the dominant contributor to overall glycemia in monitoring diabetes. Study Design and Methods: The study was carried on 664 known T2DM patients under treatment and routine follow-up at a tertiary care hospital in Bangladesh. FPG & 2-hr ABF plasma glucose concentrations were measured by hexokinase method. HbA1c was measured by high performance liquid chromatography based hemoglobin assay system. The Pearson correlation coefficient was used to investigate the relationship of FPG and ABF with HbA1c and their significance. Results: Both FPG and ABF levels were correlated with HbA1c but higher correlation was seen between FPG and HbA1c. The correlation coefficients between FPG and HbA1c and between ABF and HbA1c were 0.722 and 0.664 respectively. Both the correlations were found statistically significant (p<0.001). Conclusion: In patients with T2DM, FPG and ABF both were significantly correlated with HbA1c; and in our study we found that overall correlation of HbA1c with FPG was higher than ABF plasma glucose level.
    VL  - 3
    IS  - 4
    ER  - 

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Author Information
  • Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, No. 3, Jalan Greentown, Ipoh, Perak, Malaysia

  • Faculty of Medicine, Universiti Kuala Lumpur, Royal College of Medicine Perak, No. 3, Jalan Greentown, Ipoh, Perak, Malaysia

  • Department of Endocrinology, Bangladesh Institute of Health Sciences and Hospital, Mirpur, Bangladesh

  • Department of Endocrinology, Bangladesh Institute of Health Sciences and Hospital, Mirpur, Bangladesh

  • Department of Endocrinology, Bangladesh Institute of Health Sciences and Hospital, Mirpur, Bangladesh

  • Department of Internal Medicine (Cardiology), Gastro Liver Hospital & Research Institute Ltd, Dhaka, Bangladesh

  • Department of Biochemistry, Shahid Syed Nazrul Islam Medical College, Kishoreganj, Bangladesh

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