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Adiponectin as a Predictor for the Severity of Sepsis in ICU Patients

Received: 25 January 2015     Accepted: 31 January 2015     Published: 6 February 2015
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Abstract

Sepsis is widely diagnosed In ICU patients. The sepsis markers are numerous with variable sensitivity and specificity. Adiponectin is a protein hormone that is secreted from adipose tissue into the bloodstream. It is a key substance in metabolic syndrome and has an anti-inflammatory property. The relationship between adiponectin and sepsis is unclear. In the current study, we aim to demonstrate that low plasma adiponectin level could be an early predictor for morbidity and mortality of sepsis by its comparison with c-reactive protein, serum lactate and procalcitonine. Thirty patients admitted to the intensive care unit with picture clinically suggesting sepsis were enrolled in the study. Predisposition, insult/infection, response, and organ dysfunction (PIRO) score was used to follow the course of the septic process. Plasma adiponectin level, serum lactate level, procalcitonin level(PCT), c-reactive protein(CRP) were checked on day1 then day 4 then day 7 and so on until ICU discharge or demise for a total of 28 days . PIRO score was able to expect sepsis prognosis with high statistical significance. Procalcitonin, serum lactate and adiponectin were valuable in follow up the sepsis prognosis with P value (0, 0.01 & 0 respectively) on the contrary CRP had poor prognostic value in sepsis follow up (P value 0.16).We conclude that PIRO score is an effective model for staging of sepsis and predict mortality. Measuring serial procalcitonin levels may be the most useful in order to understand the trend, identify the peak, and be able to identify resolution of sepsis. Early high lactate level is a predictor for poor prognosis of sepsis. Adiponectin is similar to procalcitinin in early detection of sepsis & can be used as a prognostic indicator with considering that adiponectin level could be affected by other metabolic disorders.

Published in American Journal of Internal Medicine (Volume 3, Issue 1)
DOI 10.11648/j.ajim.20150301.12
Page(s) 6-14
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Sepsis, Sepsis Markers, PIRO Score, Adiponectin

References
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Cite This Article
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    Mohammed Amin Abd-Elghany, Nahed Salah Eldin, Sherif Wadie, Mervat Mohammed El Damarawy, Fady Adib Abd-El-malek, et al. (2015). Adiponectin as a Predictor for the Severity of Sepsis in ICU Patients. American Journal of Internal Medicine, 3(1), 6-14. https://doi.org/10.11648/j.ajim.20150301.12

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    ACS Style

    Mohammed Amin Abd-Elghany; Nahed Salah Eldin; Sherif Wadie; Mervat Mohammed El Damarawy; Fady Adib Abd-El-malek, et al. Adiponectin as a Predictor for the Severity of Sepsis in ICU Patients. Am. J. Intern. Med. 2015, 3(1), 6-14. doi: 10.11648/j.ajim.20150301.12

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    AMA Style

    Mohammed Amin Abd-Elghany, Nahed Salah Eldin, Sherif Wadie, Mervat Mohammed El Damarawy, Fady Adib Abd-El-malek, et al. Adiponectin as a Predictor for the Severity of Sepsis in ICU Patients. Am J Intern Med. 2015;3(1):6-14. doi: 10.11648/j.ajim.20150301.12

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  • @article{10.11648/j.ajim.20150301.12,
      author = {Mohammed Amin Abd-Elghany and Nahed Salah Eldin and Sherif Wadie and Mervat Mohammed El Damarawy and Fady Adib Abd-El-malek and Ashraf Abd El-Khalik Barakat},
      title = {Adiponectin as a Predictor for the Severity of Sepsis in ICU Patients},
      journal = {American Journal of Internal Medicine},
      volume = {3},
      number = {1},
      pages = {6-14},
      doi = {10.11648/j.ajim.20150301.12},
      url = {https://doi.org/10.11648/j.ajim.20150301.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150301.12},
      abstract = {Sepsis is widely diagnosed In ICU patients. The sepsis markers are numerous with variable sensitivity and specificity. Adiponectin is a protein hormone that is secreted from adipose tissue into the bloodstream. It is a key substance in metabolic syndrome and has an anti-inflammatory property. The relationship between adiponectin and sepsis is unclear. In the current study, we aim to demonstrate that low plasma adiponectin level could be an early predictor for morbidity and mortality of sepsis by its comparison with c-reactive protein, serum lactate and procalcitonine. Thirty patients admitted to the intensive care unit with picture clinically suggesting sepsis were enrolled in the study. Predisposition, insult/infection, response, and organ dysfunction (PIRO) score was used to follow the course of the septic process. Plasma adiponectin level, serum lactate level, procalcitonin level(PCT), c-reactive protein(CRP) were checked on day1 then day 4 then day 7 and so on until ICU discharge or demise for a total of 28 days . PIRO score was able to expect sepsis prognosis with high statistical significance. Procalcitonin, serum lactate and adiponectin were valuable in follow up the sepsis prognosis with P value (0, 0.01 & 0 respectively) on the contrary CRP had poor prognostic value in sepsis follow up (P value 0.16).We conclude that PIRO score is an effective model for staging of sepsis and predict mortality. Measuring serial procalcitonin levels may be the most useful in order to understand the trend, identify the peak, and be able to identify resolution of sepsis. Early high lactate level is a predictor for poor prognosis of sepsis. Adiponectin is similar to procalcitinin in early detection of sepsis & can be used as a prognostic indicator with considering that adiponectin level could be affected by other metabolic disorders.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Adiponectin as a Predictor for the Severity of Sepsis in ICU Patients
    AU  - Mohammed Amin Abd-Elghany
    AU  - Nahed Salah Eldin
    AU  - Sherif Wadie
    AU  - Mervat Mohammed El Damarawy
    AU  - Fady Adib Abd-El-malek
    AU  - Ashraf Abd El-Khalik Barakat
    Y1  - 2015/02/06
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajim.20150301.12
    DO  - 10.11648/j.ajim.20150301.12
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 6
    EP  - 14
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20150301.12
    AB  - Sepsis is widely diagnosed In ICU patients. The sepsis markers are numerous with variable sensitivity and specificity. Adiponectin is a protein hormone that is secreted from adipose tissue into the bloodstream. It is a key substance in metabolic syndrome and has an anti-inflammatory property. The relationship between adiponectin and sepsis is unclear. In the current study, we aim to demonstrate that low plasma adiponectin level could be an early predictor for morbidity and mortality of sepsis by its comparison with c-reactive protein, serum lactate and procalcitonine. Thirty patients admitted to the intensive care unit with picture clinically suggesting sepsis were enrolled in the study. Predisposition, insult/infection, response, and organ dysfunction (PIRO) score was used to follow the course of the septic process. Plasma adiponectin level, serum lactate level, procalcitonin level(PCT), c-reactive protein(CRP) were checked on day1 then day 4 then day 7 and so on until ICU discharge or demise for a total of 28 days . PIRO score was able to expect sepsis prognosis with high statistical significance. Procalcitonin, serum lactate and adiponectin were valuable in follow up the sepsis prognosis with P value (0, 0.01 & 0 respectively) on the contrary CRP had poor prognostic value in sepsis follow up (P value 0.16).We conclude that PIRO score is an effective model for staging of sepsis and predict mortality. Measuring serial procalcitonin levels may be the most useful in order to understand the trend, identify the peak, and be able to identify resolution of sepsis. Early high lactate level is a predictor for poor prognosis of sepsis. Adiponectin is similar to procalcitinin in early detection of sepsis & can be used as a prognostic indicator with considering that adiponectin level could be affected by other metabolic disorders.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Intensive Care Medicine Department, Theodor Bilharz Research Institute, Cairo, Egypt

  • Anesthesia and Intensive Care Medicine Department, Ain Shams University, Cairo, Egypt

  • Anesthesia and Intensive Care Medicine Department, Ain Shams University, Cairo, Egypt

  • Intensive Care Medicine Department, Theodor Bilharz Research Institute, Cairo, Egypt

  • Anesthesia and Intensive Care Medicine Department, Ain Shams University, Cairo, Egypt

  • Intensive Care Medicine Department, Theodor Bilharz Research Institute, Cairo, Egypt

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