In Japan, the prevalence of gout has increased markedly since the 1960s. Following on from the previous report, the aim of this article is to suggest what macronutrient intake is important for the prevention of gout in Japanese people in 2022 referencing the results of clinical research reported. As the previous report, the author used the data of the Comprehensive Survey of Living Conditions in Japan for the number of gout patients (1986-2022) and the data of the National Health and Nutrition Survey in Japan (1946-2022) for the intake of macronutrients. Macronutrient intake of Japanese people in 2022 were compared with those in 2019. The relationship between the number of gout patients and macronutrient intake in Japanese people was examined. The number of gout patients of Japanese people in 2022 was higher compared to that in 2019 (2019: 1.254 million; 2022: 1.306 million). Almost all gout patients were adults, and the number of gout patients were higher in men than in women. Compared to the Japanese diet in 2019, in the Japanese diet in 2022, the mean ratio of energy intake from protein in total energy intake (Protein/Energy) was the same and the mean ratio of energy intake from fat in total energy intake (Fat/Energy) increased by 0.5% and the mean ratio of energy intake from carbohydrate in total energy intake (Carbohydrate /Energy) decreased by 0.5%. The daily intake of dietary fiber of Japanese men (aged ≥ 15 years) in 2022 was below the Adequate Intakes (AIs) established by the Institute of Medicine of the National Academy of Sciences in the U.S. The Fat/Energy and Saturated fatty acids/Energy and the daily intake of saturated fatty acids, monounsaturated fatty acids, and n-6 polyunsaturated fatty acids were positively correlated with the number of gout patients, respectively. Whereas the Protein/Energy and the daily intake of energy, total carbohydrate, total protein, animal protein, and vegetable protein were negatively correlated with the number of gout patients, respectively. Modification of macronutrient intake for the prevention of gout in Japanese people (especially adults) in 2022 is suggested as follows: reduce the mean ratio of energy intake from saturated fatty acids in total energy intake (Saturated fatty acids/Energy); limiting or decreasing intake of fat, saturated fatty acids, cholesterol; increase intake of carbohydrate (particularly dietary fiber) and protein (particularly animal protein from low-fat dairy products and vegetable protein).
Published in | American Journal of Health Research (Volume 12, Issue 6) |
DOI | 10.11648/j.ajhr.20241206.16 |
Page(s) | 204-229 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Carbohydrate, Dietary Reference Intakes, Fat, Gout, Hyperuricemia, Protein, Saturated Fatty Acids, Uric Acid
[1] | GBD 2021Gout Collaborators. Global, regional, and national burden of gout, 1990-2020, and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 2024, 6(8), e507-e517. |
[2] | Dalbeth, N., Merrriman, T. R., Stamp, L. K. Gout. Lancet. 2016, 388(10055), 2039-2052. |
[3] | Zhu, Y., Pandya, B. J., Choi, H. K. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011, 63(10), 3136-3141. |
[4] | Brovold, H., Lund, T., Svistounov, D., Solbu, M. D., Jenssen, T. G., Ytrehus, K., Zykova, S. N. Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men. Scientific Reports. 2019, 9(1), 1-12. |
[5] | Bardin, T., Richette, P. Definition of hyperuricemia and gouty conditions. Current Opinion in Rheumatology. 2014, 26(2), 186-191. |
[6] | Hisatome, I., Ichida, K., Mineo, I., Ohtahara, A., Ogino, K., Kuwabara, M., Ishizaka, N., Uchida, S., Kurajoh, M., Kohagura, K., Sato, Y., Taniguchi, A., Tsuchihashi, T., Terai, C., Nakamura, T., Hamaguchi, T., Hamada, T., Fujimori, S., Masuda, I., Moriwaki, Y., Yamamoto, T. on behalf of guideline development group. Japanese Society of Gout and Uric & Nucleic Acids Guidelines for Management of Hyperuricemia and Gout: 3 rd edition. Tokyo: SHINDAN TO CHIRYO SHA, Inc.; 2018, pp. 1-169 (in Japanese). |
[7] | Duskin-Bitan, H., Cohen, E., Goldberg, E., Shochat, T., Levi, A., Garty, M., & Krause, I. The degree of asymptomatic hyperuricemia and the risk of gout: A retrospective analysis of a large cohort. Clin Rheumatol. 2014, 33(4), 549-553. |
[8] | Vedder, D., Walrabenstein, W., Heslinga, M., de Vries, R., Nurmohamed, M., van Schaardenburg, D., Gerritsen, M. Dietary interventions for gout and effect on cardiovascular risk factors: A systematic review. Nutrients. 2019, 11(12), 2955. |
[9] | Ghamri, R. A., Galai, T. A., Ismail, R. A., Aljuhani, J. M., Alotaibi, D. S., Aljahdali, M. A. Prevalence of hyperuricemia and the relationship between serum uric acid concentrations and lipid parameters among King Abdulaziz University Hospital patients. Niger J Clin Pract. 2022, 25(4), 439-447. |
[10] | Khanna, D., Fitzgerald, J. D., Khanna, P. P., Bae, S., Singh, M. K., Neogi, T., Pillinger, M. H., Merill, J., Lee, S., Prakash, S., Kaldas, M., Gogia, M., Perez-Ruiz, F., Taylor, W., Lioté, F., Choi, H., Singh, J. A., Dalbeth, N., Kaplan, S., Niyyar, V., Jones, D., Yarows, S. A., Roessler, B., Kerr, G., King, C., Levy, G., Furst, D. E., Edwards, N. L., Mandell, B., Schumacher, H. R., Robbins, M., Wenger, N., Terkeltaub, R. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Research. 2012, 64(10), 1431-1446. |
[11] | Richette, P., Doherty, M., Pascual, E., Barskova, V., Becce, F., Castaneda, J. Coyfish, M., Guillo, S., Jansen, T., Janssens, H., Lioté, F., Mallen, C. D., Nuki, G., Perez-Ruiz, F., Pimentao, J., Punzi, L., Pywell, A., So, A., Tausche, A. K., Uhlig, T., Zavada, J., Zhang, W., Tubach, F., Bardin, T. 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout. Ann Rheum Dis. 2020, 79(1), 31-38. |
[12] | Mikanagi, K. (1963) Gout in Japan. The Kyosai Medical Journal, 12, 14-37 (in Japanese). |
[13] |
The Ministry of Health, Labour and Welfare. Household Statistics Office. Comprehensive Survey of Living Conditions. Available from:
https://www.mhlw.go.jp/toukei/list/20-21kekka.html (accessed 6 May 2022). |
[14] | Kagan, A., Harris, B. R., Winkelstein, W. Jr., Johnson, K. G., Kato, H., Syme, S. L., Rhoads, G. G., Gay, M. L., Nichaman, M. Z., Hamilton, H. B., Tillotson, J. Epidemiologic studies on coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: demographic, physical, dietary and biochemical characteristics. J Chronic Dis. 1974, 27(7-8), 345-364. |
[15] | Mogawer, E. S., Hegab, M. M., Elshahaly, M., and Ragab, G. Gout: the role of diet, functional foods, and the microbiome and their interplay prevalent in North America and globally. In Functional foods and chronic disease, Aliani, M and Eskin, M. N. A., Eds., Elsevier: London, UK; 2024, pp. 153-174. |
[16] | Koguchi, T. Modification of dietary habits for prevention of gout in Japanese people: Gout and macronutrient intake. Am J Health Res. 2021. 9(5), 128-142. |
[17] | Koguchi, T. Modification of dietary habits for prevention of gout in Japanese people: Gout and micronutrient intake or alcohol consumption. Am J Health Res. 2021, 9(5), 143-157. |
[18] | Koguchi, T. Modification of macronutrient intake for prevention of gout in Japanese people in 2019: 2022 update. Am J Health Res. 2022, 10(3), 83-106. |
[19] | Koguchi, T. Modification of micronutrient intake for prevention of gout in Japanese people in 2019: 2022 update. Am J Health Res. 2022, 10(3), 107-131. |
[20] |
The Ministry of Health, Labour and Welfare. Household Statistics Office. Comprehensive Survey of Living Conditions. Available from:
https://www.e-stat.go.jp/stat-search/files?page=1&layout=datalist&toukei=00450061&tstat=000001141126&cycle=7&tclass1=000001141142&tclass2=000001142126&stat_infid=000031964417&tclass3val=0 (accessed 6 May 2022). |
[21] |
The Ministry of Health, Labour and Welfare. Household Statistics Office. Comprehensive Survey of Living Conditions. Available from:
https://www.e-stat.go.jp/dbview?sid=0003223900 (accessed 6 May 2022). |
[22] |
The Ministry of Health, Labour and Welfare. Household Statistics Office. Comprehensive Survey of Living Conditions. Available from:
https://www.e-stat.go.jp/stat-search/files?page=1&layout=datalist&toukei=00450061&tstat=000001206248&cycle=7&tclass1=000001206254&tclass2val=0 (accessed 16 October 2024). |
[23] |
The Ministry of Health, Labour and Welfare. Health Service Bureau. National Health and Nutrition Survey Japan, 1946-2017. Available from:
https://www.mhlw.go.jp/bunya/kenkou/kenkou_eiyou_chousa.html (accessed 26 May 2020). |
[24] |
National Institute of Health and Nutrition. Available from:
www.nibiohn.go.jp/eiken/kenkounippon21/eiyouchousa/keinen_henka_time.html (accessed 26 May 2020). |
[25] |
The Ministry of Health, Labour and Welfare. Health Service Bureau. National Health and Nutrition Survey Japan, 1946-2022. Available from:
https://www.mhlw.go.jp/content/10900000/001296359.pdf (accessed 18 October 2024). |
[26] |
The Ministry of Health, Labour and Welfare, Japan. Dietary Reference Intakes for Japanese, 2020. Available from:
https://www.mhlw.go.jp/file/06-Seisakujouhou-10900000-Kenkoukyoku/Overview.pdf (accessed 16 May 2022). |
[27] |
Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from:
https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[28] |
The Council for Science and Technology, Ministry of Education, Culture, Sports, Science and Technology in Japan. Standard tables of food composition in Japan -2020- (Eighth Revised Edition), Report of the Subdivision Resources. Available from:
https://www.mext.go.jp/content/20201225-mxt_kagsei-mext_01110_011.pdf (accessed 16 May 2020). |
[29] |
The Council for Science and Technology, Ministry of Education, Culture, Sports, Science and Technology in Japan. Food Composition Database. Available from:
https://fooddb.mext.go.jp/ (accessed 16 October 2024). |
[30] |
U.S. Department of Health & Human Services. National Institutes of Health. Office of Dietary Supplements. Dietary Supplement Fact Sheets. Available from:
https://ods.od.nih.gov/factsheets/list-all/ (accessed 17 May 2020). |
[31] | Yao, J., Zhang, Y., Zhao, J., Lin, Y-P., Lu, Q-Y., Fan, G-J. Cor relation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018. BMC Endocr Disord. 2022, 22(1), 196. |
[32] | Zhang, M., Ye, C., Wang, R., Zhang, Z., Huang, X., Halimulati, M., Sun, M., Ma, Y., Zhang, Z. Association between dietary acid load and hyperuricemia in Chinese adults: Analysis of the China Health and Nutrition Survey (2009). Nutrients. 2023, 15(8), 1806. |
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. |
[34] | Lecoultre, V., Egli, L., Theytaz, F., Despland, C., Schneiter, P., Tappy, L. Fructose-induced hyperuricemia is associated with a decreased renal uric acid excretion in humans. Diabetes Care. 2013, 36(9), e149-e150. |
[35] | Fang, X-Y., Qi, L-W., Chen, H-F., Gao, P., Zhang, Q., Leng, R-X., Fan, Y-G., Li, B-Z., Pan, H-F., Ye, D-Q. The interaction between dietary fructose and gut microbiota in hyperuricemia and gout. Front Nutr. 2022, 9, 890730. |
[36] | Sahebjami, H., Scalettar, R. Effects of fructose infusion on lactate and uric acid metabolism. Lancet. 1971, 297(1971), 366-369. |
[37] | Wang, D. D., Sievenpiper, J. L., de Souza, R. J., Chiavaroli, L., Ha, V., Cozma, A. I., Mirrahimi, A., Yu, M. E., Carleton, A. J., Buono, M. D., Jenkins, A. L., Leiter, L. A., Wolever, T. M. S., Beyene, J., Kendall, C. W. C., & Jenkins, D. J. A. (2012) The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr, 142, 916-923. |
[38] | Anderson, M. E., Tulp, O. L. The effects of high dietary fructose consumption on the development of gout. ES J Public Health. 2023, 4, 1019. |
[39] | FitzGerald, J. D., Dalbeth, N., Mikuls, T., Brignardello-Petersen, R., Guyatt, G., Abeles, A. M., Gelber, A. C., Harrold, L. R., Khanna, D., King, C., Levy, G., Libbey, C., Mount, D., Pillinger, M. H., Rosenthal, A., Singh, J. A., Sims, J. E., Smith, B. J., Wenger, N. S., Bae, S. S., Danve, A., Khanna, P. P., Kim, S. C., Lenert, A., Poon, S., Qasim, A., Sehra, S. T., Sharma, T. S. K., Toprover, M., Turgunbaev, M., Zeng, L., Zhang, M. A., Turner, A. S., Neogi, T. 2020 American College of Rheumatology guideline for the management of gout. Arthritis Care Research. 2020, 72(6), 744-760. |
[40] | Chandel, N. S. (2021) Carbohydrate metabolism. Cold Spring Harb Perspect Biol, 13, a040568. |
[41] | World Health Organization. Guideline: Sugars intake for adults and children. Geneva, Switzerland: WHO Press; 2015, pp. 1-49. |
[42] | Ou, G., Wu, J., Wang, S., Jiang, Y., Chen, Y., Kong, J., Xu, H., Deng, L., Zhao, H., Chen, X., Xu, L. Dietary factors and risk of gout: a two-sample mendelian randomization study. Foods. 2024, 13(8), 1269. |
[43] | Fox, I. H., John, D., DeBruyne, S., Dwosh, I., Marliss, E. B. Hyperuricemia and hypertriglyceridemia: metabolic basis for the association. Metabolism. 1985, 34(8), 741-746. |
[44] | Tappy, L., Morio, B., Azzout-Mamiche, D., Champ, M., Gerber, M., Houdart, S., Mas, E., Rizkalia, S., Slama, G., Mariotti, F., Margaritis, I. French recommendations for sugar intake in adults: a novel approach chosen by ANSES. Nutrients. 2018, 10(8), 989. |
[45] |
U.S. Department of Agriculture. (2021) Dietary Guidelines for Americans 2015-2020, 8th ed. Available from:
https://health.gov/sites/default/files/2019-09/2015-2020_Dietary_Guidelines.pdf (accessed 10 October 2021). |
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. |
[47] | Ughi, N., Prevete, I., Ramonda, R., Cavagna, L., Filippou, G., Manara, M., Bortoluzzi, A., Parisi, S., Ariani, A., Scirè, C. A. The Italian Society of Rheumatology clinical practice guidelines for the diagnosis and management of gout. Reumatismo, 2019, 71 (S1), 50-79. |
[48] |
Carlsen, H., Pajari, A-M. Dietary fiber – a scoping review for Nordic Nutrition Recommendations 2023. Food & Nutrition Research. 2023, 67, 9979.
https://doi.org/10.29219/fnr.v67.9979 eCollection 2023 |
[49] | Gose, M., Krems, C., Heuer, T., Hoffmann, I. Trends in food consumption and nutrient intake in Germany between 2006 and 2012: results of the German National Nutrition Monitoring (NEMONIT). Br J Nutr. 2016, 115(8), 1498-1507. |
[50] | European Food Safety Authority. Scientific opinion on dietary reference values for carbohydrates and dietary fibre 1EFSA panel on dietetic products, nutrition, and allergies (NDA). EFSA J. 2010, 8, 1462. |
[51] | Zykova, S. N., Storhaug, H. M., Toft, I., Chadban, S. J., Jenssen, T. G., White, S. L. Cross-sectional analysis of nutrition and serum uric acid in two Caucasian cohorts: the AusDiab Study and the Tromsø study. Nutr J. 2015, 14, 49. |
[52] | Sun, S. Z., Flickinger, B. D., Williamson-Hughes, P. S., Empie, M. W. Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab (Lond). 2010, 7, 16. |
[53] | So, M. W., Lim, D-H., Kim, S-H., Lee, S. Dietary and nutritional factors associated with hyperuricemia: The seventh Korean National Health and Nutrition Examination Survey. Asia Pac J Clin Nutr. 2020, 29(3), 609-617. |
[54] | Shatat, I. F., Abdallah, R. T., Sas, D. J., Hailpern, S. M. Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors. Pediatric Research. 2012, 72(1), 95-100. |
[55] | Zhu, Q., Yu, L., Li, Y., Man, Q., Jia, S., Zhou, Y., Zuo, H., Zhang, J. Association between dietary fiber intake and hyperuricemia among Chinese adults: Analysis of the China Adult Chronic Disease and Nutrition Surveillance (2015). Nutrients. 2022, 14(7), 1433. |
[56] | Kim, J., Jung, D. Y., Lee, J-H., Kim, M. K., Kwon, H-S., Yim, H. W., Moon, S-J. Association between serum uric acid levels and dietary fiber intake in adults: the Korea national health and nutrition examination survey (KNHANES VII, 2016-2018). Nutr Metab (Lond). 2024, 21(1), 33. |
[57] | Yu, K-H., See, L-C., Huang, Y-C., Yang, C-H., Sun, J-H. Dietary factors associated with hyperuricemia in adults. Semin Arthritis Rheum. 2008, 37(4), 243-250. |
[58] | Sun, Y., Sun, J., Zhang, P., Zhong, F., Cai, J., Ma, A. Association of dietary fiber intake with hyperuricemia in U.S. adults. Food Funct. 2019, 10(8), 4932-4940. |
[59] | Lyu, L. C., Hsu, C. Y., Yeh, C. Y., Lee, M. S., Huang, S. H., Chen, C. L. A case-control study of the association of diet and obesity with gout in Taiwan. Am J Clin Nutr. 2003, 78(4), 690-701. |
[60] | Yamaguchi, Y., Ando, C., Tsukamoto, S., Nagao, J., Ueda, T., Yamaguchi, H., & Akaoka, I. (2007) The effect on the serum uric acid level of long-term intake of chitosan-supplemented food and its safety in adults. J Jpn Soc Clin Nutr, 29, 104-113 (in Japanese). |
[61] | Carabin, I. G., Lyon, M. R., Wood, S., Pelletier, X., Donazzolo, Y., Burdock, G. A. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J. 2009, 8, 9. |
[62] | Koguchi. T., Tadokoro, T. Beneficial effect of dietary fiber on hyperuricemia in rats and humans: A review. Int. J. Vitam. Nutr. Res. 2019, 89(1-2), 89-108. |
[63] | Li, M., Cui, Z., Meng, S., Li, T., Kang, T., Ye, Q., Cao, M., Bi, Y., Meng, H. Associations between dietary glycemic index and glycemic load values and cardiometabolic risk factors in adults: findings from the China Health and Nutrition Survey. Nutrients. 2020, 13(1), 116. |
[64] | Vieira, A. T., Galväo, I., Macia, L. M., Sernaglia, É. M., Vinolo, M. A., Garcia, C. C., Tavares, L. P., Amaral, F. A., Sousa, L. P., Martins, F. S., Mackay, C. R., Teixeira, M. M. Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. J Leukoc Biol. 2017, 101(1), 275-284. |
[65] | Cao, S., Hu, Y. Interpretable machine learning framework to predict gout associated with dietary fiber and triglyceride-glucose index. Nutr Metab (Lond). 2024, 21, 25. |
[66] | Dietary Guidelines for Americans. Food sources of dietary fiber. [Internet]. Available from: |
[67] | Meng, S., Cui, Z., Li, M., Li, T., Wu, F., Kang, T., Meng, H. Associations between dietary animal and plant protein intake and cardiometabolic risk factors- a cross-sectional study in China Health and Nutrition Survey. Nutrients. 2021, 13(2), 336. |
[68] |
Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Recommended Dietary Allowances and Adequate Intakes, Total Water and Macronutrients. (2011) Washington, D.C. The National Academy Press. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK56068/table/summarytables.t4/?report=objectonly (accessed 18 October 2024). |
[69] | The World Health Organization, Food and Agriculture Organization, and United Nations University. Protein and amino acid requirements in human nutrition. Tech Rep Ser. Geneva, Switzerland: WHO Press; 2007, pp. 935. |
[70] |
UK Gout Society. (2024) All about gout and diet. Available from:
https://www.ukgoutsociety.org/docs/goutsociety-allaboutgoutanddiet-0113.pdf (accessed 16 October 2024). |
[71] | Van Elswyk, M. E., Weatherford, C. A., McNeill, S. H. A systematic review of renal health in healthy individuals associated with protein intake above the US Recommended Allowance in randomized controlled trials and observational studies. Adv Nutr. 2018, 9(4), 404-418. |
[72] | Devries, M. C., Sithamparapillai, A., Brimble, K. S., Banfield, L., Morton, R. W., Phillips, S. M. Changes in kidney function do not differ between healthy adults consuming higher- compared with lower- or normal-protein diets: A systematic review and meta-analysis. J Nutr. 2018, 148(11), 1760-1775. |
[73] | Wang, F., Sun, L., Zong, G., Gao, X., Zhang, H., Xiong, Q., Huo, S., Niu, Z., Sun, Q., Zeng, R., Li, X. Associations of amino acid and acylcarnitine profiles with incident hyperuricemia in middle-aged and older Chinese individuals. Arthritis Care Res (Hoboken). 2020, 72(9), 1305-1314. |
[74] | Teng, G. G., Pan, A., Yuan, J. M., Koh, W. P. Food sources of protein and risk of incident gout in the Singapore Chinese Health Study. Arthritis Rheumatol. 2015, 67(7), 1933-1942. |
[75] | Juraschek, S. P., McAdams-Demarco, M., Gelber, A. C., Sacks, F. M., Appel, L. J., White, K. J., Miller, E. R. Effects of lowering glycemic index of dietary carbohydrate on plasma uric acid levels: The OmniCarb Randomized Clinical Trial. Arthritis Rheumatol. 2016, 68(5), 1281-1289. |
[76] | Tracy, C. R., Best, S., Bagrodia, A., Poindexter, J. R., Adams-Huet, B., Sakhaee, K., Maalouf, N., Pak, C. Y. C., Pearle, M. S. Animal protein and the risk of kidney stones: a comparative metabolic study of animal protein sources. J Urol. 2014, 192(1), 137-141. |
[77] | Dalbeth, N., Wong, S., Gamble, G. D., Horne, A., Mason, B., Pool, B., Fairbanks, L., McQueen, F. M., Cornish, J., Reid, I. R., Palmano, K. Acute effect of milk on serum urate concentrations: a randomized controlled crossover trial. Ann Rheum Dis. 2010, 69(9), 1677-1682. |
[78] | Garrel, D. R., Verdy, M., PetitClerc, C., Martin, C., Brulé, D., Hamet, P. Milk-and soy-protein ingestion; Acute effect on serum uric acid concentration. Am J Clin Nutr. 1991, 53(3), 665-669. |
[79] | Jenkins, D. J., Kendall, C. W., Vidgen, E., Augustin, L. S., van Erk, M., Geelen, A., Parker, T., Faulkner, D., Vuksan, V., Josse, R. G., Leiter, L. A., Connelly, P. W. High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal function. Am J Clin Nutr. 2001, 74(1), 57-63. |
[80] | Hosojima, M., Kaseda, R., Kondo, H., Fujii, M., Kubota, M., Watanabe, R., Tanabe, N., Kadowaki, M., Suzuki, Y., Saito, A. Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial. BMC Nutr. 2016, 2, 25. |
[81] | Moi, J. H., Sriranganathan, M. K., Falzon, I., Edwards, C. J., van der Heijde, D. M., Buchbinder, R. Lifestyle interventions for the treatment of gout: a summary of 2 Cochrane systematic reviews. J Rheumatol. 2014, Suppl 92, 26-32. |
[82] | Chen, H., Yang, G., Chen, L., Zhao, Y., Yao, P., Li, Y., Tang, Y., Li, D. Dietary polyunsaturated fatty acids intake is negatively associated with hyperuricemia: the National Health and Nutrition Examination Survey 2003-2015. Nutr Metab Cardiovasc Dis. 2024, 34(9), 2203-2216. |
[83] | Zhang, M., Zhang, Y., Terkeltaub, R., Chen, C., & Neogi, T. Effect of dietary and supplemental omega-3 polyunsaturated fatty acids on risk of recurrent gout flares. Arthritis Rheumatol. 2019, 71(9), 1580-1586. |
[84] | Abhishek, A., Valdes, A. M., Doherty, M. Low omega-3 fatty acid levels associate with frequent gout attacks: a case control study. Annals of the Rheumatic Diseases. 2016, 75(4), 784-785. |
[85] | Iverson, C., Bacong, A., Liu, S., Baumgartner, S., Lundström, T., Oscarsson, J., Miner, J. N. Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation. Scientific Reports. 2018, 8(1), 1217. |
[86] | Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., Zhou, R. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013, 38(6), 1154-1163. |
[87] | Tate, G. A., Mandell, B. F., Karmali, R. A., Laposata, M., Baker, D. G., Schumacher, H. R. Jr., Zurier, R. B. Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. Arthritis Rheum. 1988, 31(12), 1543-1551. |
[88] | Saito, H., Toyoda, Y., Takada, T., Hirata, H., Ota-kontani, A., Miyata, H., Kobayashi, N., Tsuchiya, Y., Suzuki, H. n-3 polyunsaturated fatty acids inhibit the function of human URAT 1, a renal urate re-absorber. Nutrients. 2020, 12(6), 1601. |
[89] | Egert, S., Lindenmeier, M., Harnack, K., Krome, K., Erbersdobler, H. F., Wahrburg, U., Somoza, V. Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. The Journal of Nutrition. 2012, 142(9), 1638-1644. |
[90] | Ekpenyong, C. E., Daniel, N. Roles of diets and dietary factors in the pathogenesis, management and prevention of abnormal serum uric acid levels. Pharma Nutrition. 2015, 3(2), 29-45. |
[91] | Huang, T., Li, K., Asimi, S., Chen, Q., Li, D. Effect of vitamin B-12 and n-3 polyunsaturated fatty acids on plasma homocysteine, ferritin, C-reactive protein, and other cardiovascular risk factors: a randomized controlled trial. Asia Pac J Clin Nutr. 2015, 24(3), 403-411. |
[92] | Li, K., Wu, K., Zhao, Y., Huang, T., Lou, D., Yu, X., Li, D. Interaction between marine-derived n-3 long chain polyunsaturated fatty acids and uric acid on glucose metabolism and risk of type 2 diabetes mellitus: a case-control study. Mar Drugs. 2015, 13(9), 5564-5578. |
[93] | Paoli, A., Moro, T., Bosco, G., Bianco, A., Grimaldi, K. A., Camporesi, E., Mangar, D. Effects of n-3 polyunsaturated fatty acids (ω-3) supplementation on some cardiovascular risk factors with a ketogenic Mediterranean diet. Mar Drugs. 2015, 13(2), 996-1009. |
[94] | Stamp, L. K., Grainger, R., Frampton, C., Drake, J., Hill, C. L. Effect of omega-three supplementation on serum urate and gout flares in people with gout: a pilot randomized trial. BMC Rheumatol. 2022, 6(1), 31. |
[95] |
U.S. Department of Health & Human Services. National Institutes of Health. Omega 3 Fatty Acids. Office of Dietary Supplements. Dietary Supplement Fact Sheets. Available from:
https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional / (accessed 16 October 2024). |
[96] | Mozaffarian, D., Wu, J. H. Y. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol. 2011, 58(20), 2047-2067. |
[97] | The Ministry of Agriculture, Forestry and Fisheries. WASHOKU, traditional dietary cultures of the Japanese. Available from: |
[98] | Koguchi, T. Modification of dietary habits for prevention of gout in Japanese people: Gout and diet. Am J Health Res. 2021, 9(5), 176-189. |
APA Style
Koguchi, T. (2024). Modification of Macronutrient Intake for Prevention of Gout in Japanese People in 2022: 2024 Update. American Journal of Health Research, 12(6), 204-229. https://doi.org/10.11648/j.ajhr.20241206.16
ACS Style
Koguchi, T. Modification of Macronutrient Intake for Prevention of Gout in Japanese People in 2022: 2024 Update. Am. J. Health Res. 2024, 12(6), 204-229. doi: 10.11648/j.ajhr.20241206.16
AMA Style
Koguchi T. Modification of Macronutrient Intake for Prevention of Gout in Japanese People in 2022: 2024 Update. Am J Health Res. 2024;12(6):204-229. doi: 10.11648/j.ajhr.20241206.16
@article{10.11648/j.ajhr.20241206.16, author = {Takashi Koguchi}, title = {Modification of Macronutrient Intake for Prevention of Gout in Japanese People in 2022: 2024 Update }, journal = {American Journal of Health Research}, volume = {12}, number = {6}, pages = {204-229}, doi = {10.11648/j.ajhr.20241206.16}, url = {https://doi.org/10.11648/j.ajhr.20241206.16}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20241206.16}, abstract = {In Japan, the prevalence of gout has increased markedly since the 1960s. Following on from the previous report, the aim of this article is to suggest what macronutrient intake is important for the prevention of gout in Japanese people in 2022 referencing the results of clinical research reported. As the previous report, the author used the data of the Comprehensive Survey of Living Conditions in Japan for the number of gout patients (1986-2022) and the data of the National Health and Nutrition Survey in Japan (1946-2022) for the intake of macronutrients. Macronutrient intake of Japanese people in 2022 were compared with those in 2019. The relationship between the number of gout patients and macronutrient intake in Japanese people was examined. The number of gout patients of Japanese people in 2022 was higher compared to that in 2019 (2019: 1.254 million; 2022: 1.306 million). Almost all gout patients were adults, and the number of gout patients were higher in men than in women. Compared to the Japanese diet in 2019, in the Japanese diet in 2022, the mean ratio of energy intake from protein in total energy intake (Protein/Energy) was the same and the mean ratio of energy intake from fat in total energy intake (Fat/Energy) increased by 0.5% and the mean ratio of energy intake from carbohydrate in total energy intake (Carbohydrate /Energy) decreased by 0.5%. The daily intake of dietary fiber of Japanese men (aged ≥ 15 years) in 2022 was below the Adequate Intakes (AIs) established by the Institute of Medicine of the National Academy of Sciences in the U.S. The Fat/Energy and Saturated fatty acids/Energy and the daily intake of saturated fatty acids, monounsaturated fatty acids, and n-6 polyunsaturated fatty acids were positively correlated with the number of gout patients, respectively. Whereas the Protein/Energy and the daily intake of energy, total carbohydrate, total protein, animal protein, and vegetable protein were negatively correlated with the number of gout patients, respectively. Modification of macronutrient intake for the prevention of gout in Japanese people (especially adults) in 2022 is suggested as follows: reduce the mean ratio of energy intake from saturated fatty acids in total energy intake (Saturated fatty acids/Energy); limiting or decreasing intake of fat, saturated fatty acids, cholesterol; increase intake of carbohydrate (particularly dietary fiber) and protein (particularly animal protein from low-fat dairy products and vegetable protein). }, year = {2024} }
TY - JOUR T1 - Modification of Macronutrient Intake for Prevention of Gout in Japanese People in 2022: 2024 Update AU - Takashi Koguchi Y1 - 2024/11/26 PY - 2024 N1 - https://doi.org/10.11648/j.ajhr.20241206.16 DO - 10.11648/j.ajhr.20241206.16 T2 - American Journal of Health Research JF - American Journal of Health Research JO - American Journal of Health Research SP - 204 EP - 229 PB - Science Publishing Group SN - 2330-8796 UR - https://doi.org/10.11648/j.ajhr.20241206.16 AB - In Japan, the prevalence of gout has increased markedly since the 1960s. Following on from the previous report, the aim of this article is to suggest what macronutrient intake is important for the prevention of gout in Japanese people in 2022 referencing the results of clinical research reported. As the previous report, the author used the data of the Comprehensive Survey of Living Conditions in Japan for the number of gout patients (1986-2022) and the data of the National Health and Nutrition Survey in Japan (1946-2022) for the intake of macronutrients. Macronutrient intake of Japanese people in 2022 were compared with those in 2019. The relationship between the number of gout patients and macronutrient intake in Japanese people was examined. The number of gout patients of Japanese people in 2022 was higher compared to that in 2019 (2019: 1.254 million; 2022: 1.306 million). Almost all gout patients were adults, and the number of gout patients were higher in men than in women. Compared to the Japanese diet in 2019, in the Japanese diet in 2022, the mean ratio of energy intake from protein in total energy intake (Protein/Energy) was the same and the mean ratio of energy intake from fat in total energy intake (Fat/Energy) increased by 0.5% and the mean ratio of energy intake from carbohydrate in total energy intake (Carbohydrate /Energy) decreased by 0.5%. The daily intake of dietary fiber of Japanese men (aged ≥ 15 years) in 2022 was below the Adequate Intakes (AIs) established by the Institute of Medicine of the National Academy of Sciences in the U.S. The Fat/Energy and Saturated fatty acids/Energy and the daily intake of saturated fatty acids, monounsaturated fatty acids, and n-6 polyunsaturated fatty acids were positively correlated with the number of gout patients, respectively. Whereas the Protein/Energy and the daily intake of energy, total carbohydrate, total protein, animal protein, and vegetable protein were negatively correlated with the number of gout patients, respectively. Modification of macronutrient intake for the prevention of gout in Japanese people (especially adults) in 2022 is suggested as follows: reduce the mean ratio of energy intake from saturated fatty acids in total energy intake (Saturated fatty acids/Energy); limiting or decreasing intake of fat, saturated fatty acids, cholesterol; increase intake of carbohydrate (particularly dietary fiber) and protein (particularly animal protein from low-fat dairy products and vegetable protein). VL - 12 IS - 6 ER -