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Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China

Received: 1 August 2019     Accepted: 23 August 2019     Published: 5 September 2019
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Abstract

Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. According to l:l matched pairs design, 342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.

Published in American Journal of Health Research (Volume 7, Issue 5)
DOI 10.11648/j.ajhr.20190705.14
Page(s) 79-84
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Hypertension, Family History, Onset Age, Effect

References
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    Anle Li, Qian Peng, Yueqin Shao, Yiying Zhang, Xiang Fang. (2019). Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China. American Journal of Health Research, 7(5), 79-84. https://doi.org/10.11648/j.ajhr.20190705.14

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    ACS Style

    Anle Li; Qian Peng; Yueqin Shao; Yiying Zhang; Xiang Fang. Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China. Am. J. Health Res. 2019, 7(5), 79-84. doi: 10.11648/j.ajhr.20190705.14

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    AMA Style

    Anle Li, Qian Peng, Yueqin Shao, Yiying Zhang, Xiang Fang. Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China. Am J Health Res. 2019;7(5):79-84. doi: 10.11648/j.ajhr.20190705.14

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  • @article{10.11648/j.ajhr.20190705.14,
      author = {Anle Li and Qian Peng and Yueqin Shao and Yiying Zhang and Xiang Fang},
      title = {Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China},
      journal = {American Journal of Health Research},
      volume = {7},
      number = {5},
      pages = {79-84},
      doi = {10.11648/j.ajhr.20190705.14},
      url = {https://doi.org/10.11648/j.ajhr.20190705.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20190705.14},
      abstract = {Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. According to l:l matched pairs design, 342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China
    AU  - Anle Li
    AU  - Qian Peng
    AU  - Yueqin Shao
    AU  - Yiying Zhang
    AU  - Xiang Fang
    Y1  - 2019/09/05
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajhr.20190705.14
    DO  - 10.11648/j.ajhr.20190705.14
    T2  - American Journal of Health Research
    JF  - American Journal of Health Research
    JO  - American Journal of Health Research
    SP  - 79
    EP  - 84
    PB  - Science Publishing Group
    SN  - 2330-8796
    UR  - https://doi.org/10.11648/j.ajhr.20190705.14
    AB  - Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. According to l:l matched pairs design, 342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.
    VL  - 7
    IS  - 5
    ER  - 

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Author Information
  • Jiading District Center for Disease Control and Prevention, Shanghai, China

  • Jiading District Center for Disease Control and Prevention, Shanghai, China

  • Jiading District Center for Disease Control and Prevention, Shanghai, China

  • Jiading District Center for Disease Control and Prevention, Shanghai, China

  • Jiading District Center for Disease Control and Prevention, Shanghai, China

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