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Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children

Received: 24 January 2016     Accepted: 4 February 2016     Published: 15 February 2017
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Abstract

Background: Lung Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. Tb). Excessive body's immune response to M. Tb will contribute to the host tissue damage. M. Tb infection stimulates gene expression and MMP-9 secretion from monocyte which is infected by M. Tb. M. Tb molecular mechanisms inducing granuloma formation which is the ESAT-6 protein that stimulates the production of matrix metalloproteinase-9 (MMP-9) from epithelial cells near the infected macrophages. Objective: To evaluate the levels of Matrix Metalloproteinase-9 (MMP-9) in children who lived in the same house with a tuberculosis person. Methods: A cross sectional study was conducted at the Lung Health Community Center (BBKPM) Makassar, from May to July 2015. The study population was children aged 3 months to 18 years. Results: Levels of MMP-9 were examined in 55 samples of the study, 29 samples infected with TB (52.7%), and 26 samples exposed to TB (47.3%). There is no significant difference in the levels of MMP-9 and genders, age, nutritional status, status of BCG, as well as the levels of MMP-9 in the group of exposed and infected to TB (p>0.05). Conclusion: There was no significant differences between the levels of MMP-9 in the group of exposed and infected to TB.

Published in American Journal of Health Research (Volume 5, Issue 1)
DOI 10.11648/j.ajhr.20170501.12
Page(s) 7-10
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Matrix Metalloproteinase-9 (MMP-9), Tuberculosis Exposed Children, Tuberculosis Infected Children

References
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[4] Rundhaug, J. E. Matrix metalloproteinase, Angiogenesis and Cancer. Clinicancerres. 9: 551-554. 2003.
[5] Welgus, H. G., Campbell E. J., Cury, J. D., Eisen, A. Z., Senior, R. M., Wilhelm, S. M., Goldberg, G. I. Neutral Metalloproteinase Produced by Human Mononuclear Phagocytes. Enzyme Profile, Regulation, and Expression during Cellular Development. J. Clin. Invest. The American Society for Clinical Investigation, Inc. 1990.
[6] Stuelten CH., Byfield SD., Arany PR., Karpova TS., Stevenson W. G. S., Roberts A. B. Breast cancer cells induce stromal fibroblast to express MMP-9 via secretion of TNF-α and TGF-β. Journal of cell science 118. 2143-2153. 2005.
[7] Ehlers, S., Schaible, U. E. The granuloma in tuberculosis: dynamics of a host–pathogen collusion. Available at. www.frontiersin.org. 2013.
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[13] Sundstrom J., Evans JC., Benjamin EJ., Lew D., Larson MG., Sawyer DB., Siwik DA., Colucci WS., Sutherland P., Wilson PW., Vasan RS. Relation of plasma matrix metalloproteinase-9 to clinial cardiovaskular risk factors and echocardiographic left ventrikular measures: 109: 2850-2856). 2004.
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[15] Lee CY., Shim HS., Lee S., Lee JG., Kim DJ., Chung KY. Prognostic effect of matrix metalloproteinase-9 in patients with resected non small cell lung cancer. Journal of cardiothoracic surgery 10; 44. 2015.
[16] Lacerda L. Faria APD., Fontana V., Moreno H., Sandrim V. Role of MMP-2 and MMP-9 in resistance to drug therapy in patients with resistant hypertension. 2015.
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Cite This Article
  • APA Style

    Wildana Azikin, Amiruddin Laompo, Husein Albar, Dasril Daud. (2017). Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children. American Journal of Health Research, 5(1), 7-10. https://doi.org/10.11648/j.ajhr.20170501.12

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    ACS Style

    Wildana Azikin; Amiruddin Laompo; Husein Albar; Dasril Daud. Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children. Am. J. Health Res. 2017, 5(1), 7-10. doi: 10.11648/j.ajhr.20170501.12

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    AMA Style

    Wildana Azikin, Amiruddin Laompo, Husein Albar, Dasril Daud. Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children. Am J Health Res. 2017;5(1):7-10. doi: 10.11648/j.ajhr.20170501.12

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  • @article{10.11648/j.ajhr.20170501.12,
      author = {Wildana Azikin and Amiruddin Laompo and Husein Albar and Dasril Daud},
      title = {Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children},
      journal = {American Journal of Health Research},
      volume = {5},
      number = {1},
      pages = {7-10},
      doi = {10.11648/j.ajhr.20170501.12},
      url = {https://doi.org/10.11648/j.ajhr.20170501.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20170501.12},
      abstract = {Background: Lung Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. Tb). Excessive body's immune response to M. Tb will contribute to the host tissue damage. M. Tb infection stimulates gene expression and MMP-9 secretion from monocyte which is infected by M. Tb. M. Tb molecular mechanisms inducing granuloma formation which is the ESAT-6 protein that stimulates the production of matrix metalloproteinase-9 (MMP-9) from epithelial cells near the infected macrophages. Objective: To evaluate the levels of Matrix Metalloproteinase-9 (MMP-9) in children who lived in the same house with a tuberculosis person. Methods: A cross sectional study was conducted at the Lung Health Community Center (BBKPM) Makassar, from May to July 2015. The study population was children aged 3 months to 18 years. Results: Levels of MMP-9 were examined in 55 samples of the study, 29 samples infected with TB (52.7%), and 26 samples exposed to TB (47.3%). There is no significant difference in the levels of MMP-9 and genders, age, nutritional status, status of BCG, as well as the levels of MMP-9 in the group of exposed and infected to TB (p>0.05). Conclusion: There was no significant differences between the levels of MMP-9 in the group of exposed and infected to TB.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Matrix Metalloproteinase-9 (MMP-9) Level in Tuberculosis Exposed and Infected Children
    AU  - Wildana Azikin
    AU  - Amiruddin Laompo
    AU  - Husein Albar
    AU  - Dasril Daud
    Y1  - 2017/02/15
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ajhr.20170501.12
    DO  - 10.11648/j.ajhr.20170501.12
    T2  - American Journal of Health Research
    JF  - American Journal of Health Research
    JO  - American Journal of Health Research
    SP  - 7
    EP  - 10
    PB  - Science Publishing Group
    SN  - 2330-8796
    UR  - https://doi.org/10.11648/j.ajhr.20170501.12
    AB  - Background: Lung Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M. Tb). Excessive body's immune response to M. Tb will contribute to the host tissue damage. M. Tb infection stimulates gene expression and MMP-9 secretion from monocyte which is infected by M. Tb. M. Tb molecular mechanisms inducing granuloma formation which is the ESAT-6 protein that stimulates the production of matrix metalloproteinase-9 (MMP-9) from epithelial cells near the infected macrophages. Objective: To evaluate the levels of Matrix Metalloproteinase-9 (MMP-9) in children who lived in the same house with a tuberculosis person. Methods: A cross sectional study was conducted at the Lung Health Community Center (BBKPM) Makassar, from May to July 2015. The study population was children aged 3 months to 18 years. Results: Levels of MMP-9 were examined in 55 samples of the study, 29 samples infected with TB (52.7%), and 26 samples exposed to TB (47.3%). There is no significant difference in the levels of MMP-9 and genders, age, nutritional status, status of BCG, as well as the levels of MMP-9 in the group of exposed and infected to TB (p>0.05). Conclusion: There was no significant differences between the levels of MMP-9 in the group of exposed and infected to TB.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia

  • Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia

  • Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia

  • Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi, Indonesia

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