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Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load

Received: 2 September 2015     Accepted: 16 September 2015     Published: 28 September 2015
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Abstract

A significant decrease in weight of ovary and oviduct of female rats was noted following lead nitrate administration with a dose 80 mg/kg body weight/day for 28 days. Histomicrogaphs of ovary showed marked inhibition of follicular growth as judged by gradual decrease oocyte size, absence of theca and granulosa layer, resulting absence of graafian follicle. Oviduct showed shrinkage in lumen and damage in perimetrium cells. Increase in total protein of ovary and oviduct after lead nitrate treatment denoting changes at translational level of concern gene to prevent the normal physiology. A significant increase in the thiobarbituric acid reactive substances (TBARS) of both tissues denotes increased free radical load resulted in the damage of cellular architecture. Findings, suggest that lead entering to the biological system via environment and other widely used industrial product may interfere with the normal reproductive physiology and folliculogenesis could be one of the cause of female infertility.

Published in Advances in Bioscience and Bioengineering (Volume 3, Issue 5)
DOI 10.11648/j.abb.20150305.11
Page(s) 49-55
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Lead Nitrate Toxicity, TBARS, Ovary, Oviduct

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Cite This Article
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    Seema Rai, Muddasir Basheer, Deepika Acharya, Hindole Ghosh, Pritam Bhattacharya. (2015). Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load. Advances in Bioscience and Bioengineering, 3(5), 49-55. https://doi.org/10.11648/j.abb.20150305.11

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    ACS Style

    Seema Rai; Muddasir Basheer; Deepika Acharya; Hindole Ghosh; Pritam Bhattacharya. Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load. Adv. BioSci. Bioeng. 2015, 3(5), 49-55. doi: 10.11648/j.abb.20150305.11

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    AMA Style

    Seema Rai, Muddasir Basheer, Deepika Acharya, Hindole Ghosh, Pritam Bhattacharya. Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load. Adv BioSci Bioeng. 2015;3(5):49-55. doi: 10.11648/j.abb.20150305.11

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  • @article{10.11648/j.abb.20150305.11,
      author = {Seema Rai and Muddasir Basheer and Deepika Acharya and Hindole Ghosh and Pritam Bhattacharya},
      title = {Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load},
      journal = {Advances in Bioscience and Bioengineering},
      volume = {3},
      number = {5},
      pages = {49-55},
      doi = {10.11648/j.abb.20150305.11},
      url = {https://doi.org/10.11648/j.abb.20150305.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20150305.11},
      abstract = {A significant decrease in weight of ovary and oviduct of female rats was noted following lead nitrate administration with a dose 80 mg/kg body weight/day for 28 days. Histomicrogaphs of ovary showed marked inhibition of follicular growth as judged by gradual decrease oocyte size, absence of theca and granulosa layer, resulting absence of graafian follicle. Oviduct showed shrinkage in lumen and damage in perimetrium cells. Increase in total protein of ovary and oviduct after lead nitrate treatment denoting changes at translational level of concern gene to prevent the normal physiology. A significant increase in the thiobarbituric acid reactive substances (TBARS) of both tissues denotes increased free radical load resulted in the damage of cellular architecture. Findings, suggest that lead entering to the biological system via environment and other widely used industrial product may interfere with the normal reproductive physiology and folliculogenesis could be one of the cause of female infertility.},
     year = {2015}
    }
    

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    T1  - Impairment of Ovarian and Uterine Cellular Architecture, Total Protein Content: A Consequence of Lead Nitrate Induced Increased Free Radical Load
    AU  - Seema Rai
    AU  - Muddasir Basheer
    AU  - Deepika Acharya
    AU  - Hindole Ghosh
    AU  - Pritam Bhattacharya
    Y1  - 2015/09/28
    PY  - 2015
    N1  - https://doi.org/10.11648/j.abb.20150305.11
    DO  - 10.11648/j.abb.20150305.11
    T2  - Advances in Bioscience and Bioengineering
    JF  - Advances in Bioscience and Bioengineering
    JO  - Advances in Bioscience and Bioengineering
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    PB  - Science Publishing Group
    SN  - 2330-4162
    UR  - https://doi.org/10.11648/j.abb.20150305.11
    AB  - A significant decrease in weight of ovary and oviduct of female rats was noted following lead nitrate administration with a dose 80 mg/kg body weight/day for 28 days. Histomicrogaphs of ovary showed marked inhibition of follicular growth as judged by gradual decrease oocyte size, absence of theca and granulosa layer, resulting absence of graafian follicle. Oviduct showed shrinkage in lumen and damage in perimetrium cells. Increase in total protein of ovary and oviduct after lead nitrate treatment denoting changes at translational level of concern gene to prevent the normal physiology. A significant increase in the thiobarbituric acid reactive substances (TBARS) of both tissues denotes increased free radical load resulted in the damage of cellular architecture. Findings, suggest that lead entering to the biological system via environment and other widely used industrial product may interfere with the normal reproductive physiology and folliculogenesis could be one of the cause of female infertility.
    VL  - 3
    IS  - 5
    ER  - 

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Author Information
  • Department of Zoology, School of Life Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh

  • Department of Zoology, School of Life Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh

  • Department of Zoology, School of Life Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh

  • Department of Zoology, School of Life Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh

  • Department of Zoology, School of Life Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh

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