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Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes

Received: 5 November 2020     Accepted: 20 November 2020     Published: 27 November 2020
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Abstract

Type 2 diabetes or diabetes mellitus is a metabolic disorder characterized by an increase in blood sugar level. It is caused by a lack of insulin secretion, insulin action, or both. There are approximately 501,530 people living with diabetes in Côte d’Ivoire with an estimated prevalence of 5.19% in 2013. Unfortunately impairment of zinc and copper leads to increased oxidative stress, insulin resistance and diabetic complications. The study aimed to assess the zinc and copper status in patients with type 2 diabetes. This study involved 80 type 2 diabetics and 80 non-diabetic as controls. Glycated hemoglobin (HbA1c) was analyzed in whole blood using the Hitachi Roche Cobas C311. The serum assays of zinc and copper then of glycemia were carried out using a flame-air / acetylene atomic absorption spectrophotometer (AAS) of the brand Varian Spectr AA-20 Victoria, Australia and on the Cobas C311 respectively. A significant decrease in zinc content (P ˂ 0.0001) and a significant increase in copper content as well as the Cu / Zn ratio (P ˂ 0.0001) were observed in type 2 diabetic patients compared to non-diabetic control. The lower serum zinc values and the high Cu / Zn ratio could justify the high level of oxidative stress in patients with type 2 diabetes. Assessment of zinc and copper is essential in the monitoring of complications due to type 2 diabetes.

Published in Advances in Biochemistry (Volume 8, Issue 4)
DOI 10.11648/j.ab.20200804.11
Page(s) 57-61
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Copper, Côte D'ivoire, Oxidative Stress, Type 2 Diabetics, Zinc

References
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Cite This Article
  • APA Style

    N’Guessan Assieoussou Jean-Luc, Boyvin Lydie, Bahi Gnogbo Alexis, Moke-Bedji Louise Odile, Yaye Yapi Guillaume, et al. (2020). Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes. Advances in Biochemistry, 8(4), 57-61. https://doi.org/10.11648/j.ab.20200804.11

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    ACS Style

    N’Guessan Assieoussou Jean-Luc; Boyvin Lydie; Bahi Gnogbo Alexis; Moke-Bedji Louise Odile; Yaye Yapi Guillaume, et al. Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes. Adv. Biochem. 2020, 8(4), 57-61. doi: 10.11648/j.ab.20200804.11

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    AMA Style

    N’Guessan Assieoussou Jean-Luc, Boyvin Lydie, Bahi Gnogbo Alexis, Moke-Bedji Louise Odile, Yaye Yapi Guillaume, et al. Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes. Adv Biochem. 2020;8(4):57-61. doi: 10.11648/j.ab.20200804.11

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  • @article{10.11648/j.ab.20200804.11,
      author = {N’Guessan Assieoussou Jean-Luc and Boyvin Lydie and Bahi Gnogbo Alexis and Moke-Bedji Louise Odile and Yaye Yapi Guillaume and Ankotche Amos and Djaman Allico Joseph},
      title = {Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes},
      journal = {Advances in Biochemistry},
      volume = {8},
      number = {4},
      pages = {57-61},
      doi = {10.11648/j.ab.20200804.11},
      url = {https://doi.org/10.11648/j.ab.20200804.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20200804.11},
      abstract = {Type 2 diabetes or diabetes mellitus is a metabolic disorder characterized by an increase in blood sugar level. It is caused by a lack of insulin secretion, insulin action, or both. There are approximately 501,530 people living with diabetes in Côte d’Ivoire with an estimated prevalence of 5.19% in 2013. Unfortunately impairment of zinc and copper leads to increased oxidative stress, insulin resistance and diabetic complications. The study aimed to assess the zinc and copper status in patients with type 2 diabetes. This study involved 80 type 2 diabetics and 80 non-diabetic as controls. Glycated hemoglobin (HbA1c) was analyzed in whole blood using the Hitachi Roche Cobas C311. The serum assays of zinc and copper then of glycemia were carried out using a flame-air / acetylene atomic absorption spectrophotometer (AAS) of the brand Varian Spectr AA-20 Victoria, Australia and on the Cobas C311 respectively. A significant decrease in zinc content (P ˂ 0.0001) and a significant increase in copper content as well as the Cu / Zn ratio (P ˂ 0.0001) were observed in type 2 diabetic patients compared to non-diabetic control. The lower serum zinc values and the high Cu / Zn ratio could justify the high level of oxidative stress in patients with type 2 diabetes. Assessment of zinc and copper is essential in the monitoring of complications due to type 2 diabetes.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Assessment of Serum Zinc and Copper Levels, and Cu / Zn Ratio Among Patients of Côte D’Ivoire with Type 2 Diabetes
    AU  - N’Guessan Assieoussou Jean-Luc
    AU  - Boyvin Lydie
    AU  - Bahi Gnogbo Alexis
    AU  - Moke-Bedji Louise Odile
    AU  - Yaye Yapi Guillaume
    AU  - Ankotche Amos
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    DO  - 10.11648/j.ab.20200804.11
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
    SP  - 57
    EP  - 61
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20200804.11
    AB  - Type 2 diabetes or diabetes mellitus is a metabolic disorder characterized by an increase in blood sugar level. It is caused by a lack of insulin secretion, insulin action, or both. There are approximately 501,530 people living with diabetes in Côte d’Ivoire with an estimated prevalence of 5.19% in 2013. Unfortunately impairment of zinc and copper leads to increased oxidative stress, insulin resistance and diabetic complications. The study aimed to assess the zinc and copper status in patients with type 2 diabetes. This study involved 80 type 2 diabetics and 80 non-diabetic as controls. Glycated hemoglobin (HbA1c) was analyzed in whole blood using the Hitachi Roche Cobas C311. The serum assays of zinc and copper then of glycemia were carried out using a flame-air / acetylene atomic absorption spectrophotometer (AAS) of the brand Varian Spectr AA-20 Victoria, Australia and on the Cobas C311 respectively. A significant decrease in zinc content (P ˂ 0.0001) and a significant increase in copper content as well as the Cu / Zn ratio (P ˂ 0.0001) were observed in type 2 diabetic patients compared to non-diabetic control. The lower serum zinc values and the high Cu / Zn ratio could justify the high level of oxidative stress in patients with type 2 diabetes. Assessment of zinc and copper is essential in the monitoring of complications due to type 2 diabetes.
    VL  - 8
    IS  - 4
    ER  - 

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Author Information
  • Biosciences Training and Research Unit, Felix Houphou?t-Boigny University, Abidjan, C?te d’Ivoire

  • Biosciences Training and Research Unit, Felix Houphou?t-Boigny University, Abidjan, C?te d’Ivoire

  • Department of Clinical and Fundamental Biochemistry of Institut Pasteur, Abidjan, C?te d’Ivoire

  • Diabetes and Hypertension Clinic Beda Yao Bernard of University Teaching Hospital, Abidjan, C?te d’Ivoire

  • Agroforestry Training and Research Unit, Jean Lorougnon Guede University, Daloa, C?te d’Ivoire

  • Diabetes and Hypertension Clinic Beda Yao Bernard of University Teaching Hospital, Abidjan, C?te d’Ivoire

  • Biosciences Training and Research Unit, Felix Houphou?t-Boigny University, Abidjan, C?te d’Ivoire

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