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Cathepsins B, L and H Splenocytes as the Secondary Antioxidant Systems in the Conditions of Carbonyl Stress

Received: 19 December 2014     Accepted: 6 January 2015     Published: 27 January 2015
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Abstract

In the conditions of synthesis of nitrogen oxide deficit` modelling there is a growth of carbonyl derived proteins due to basic aldehyde- and keton-dinitrophenylhydrazones. After adding L-NAME into the incubation medium there appears aggravation of the carbonyl stress as the result of growth of oxidative stress secondary markers content and exhausting of reserve-adaptative resource. Activation of cathepsins L and H splenocytes takes place in response to oxidative modified proteins elaboration which is proved by our positive correlative conjunction.

Published in Advances in Biochemistry (Volume 3, Issue 1)
DOI 10.11648/j.ab.20150301.12
Page(s) 5-8
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Carbonyl Derived Proteins, Cathepsins, Oxidative Stress, L-NAME

References
[1] Barrett A.J., Kirschke H. (1981) Cathepsin B, cathepsin H, cathepsin L. Methods in Enzymol. 80, 535-561.
[2] Davies K.J. (2001) Degradation of oxidized proteins by the 20S proteasome. Biochimie.- 2001. 83 (3/4), 301-310.
[3] Levine R.L. et al. (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186. 464–478.
[4] Ogino Keiki and Wang Da-Hong (2007) Biomarkers of Oxidative/NitrosativeStress:An Approach to Disease Prevention. Acta Med. Okayama. 61 (4), 181-189.
[5] Rossner Pavel Jr. et al. (2007) Oxidative and nitrosative stress markers in bus drivers. Mutation Research. 617, 23–32.
[6] Volkan Ergin et al. (2013) Carbonyl Stress in Aging Process: Role of Vitamins and Phytochemicals as Redox Regulators. Aging and Disease, 4 (5). P. 279-294
Cite This Article
  • APA Style

    Fomina Maria Alekseevna, Abalenikhina Yulia Vladimirovna. (2015). Cathepsins B, L and H Splenocytes as the Secondary Antioxidant Systems in the Conditions of Carbonyl Stress. Advances in Biochemistry, 3(1), 5-8. https://doi.org/10.11648/j.ab.20150301.12

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    ACS Style

    Fomina Maria Alekseevna; Abalenikhina Yulia Vladimirovna. Cathepsins B, L and H Splenocytes as the Secondary Antioxidant Systems in the Conditions of Carbonyl Stress. Adv. Biochem. 2015, 3(1), 5-8. doi: 10.11648/j.ab.20150301.12

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    AMA Style

    Fomina Maria Alekseevna, Abalenikhina Yulia Vladimirovna. Cathepsins B, L and H Splenocytes as the Secondary Antioxidant Systems in the Conditions of Carbonyl Stress. Adv Biochem. 2015;3(1):5-8. doi: 10.11648/j.ab.20150301.12

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  • @article{10.11648/j.ab.20150301.12,
      author = {Fomina Maria Alekseevna and Abalenikhina Yulia Vladimirovna},
      title = {Cathepsins B, L and H Splenocytes as the Secondary Antioxidant Systems in the Conditions of Carbonyl Stress},
      journal = {Advances in Biochemistry},
      volume = {3},
      number = {1},
      pages = {5-8},
      doi = {10.11648/j.ab.20150301.12},
      url = {https://doi.org/10.11648/j.ab.20150301.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20150301.12},
      abstract = {In the conditions of synthesis of nitrogen oxide deficit` modelling there is a growth of carbonyl derived proteins due to basic aldehyde- and keton-dinitrophenylhydrazones. After adding L-NAME into the incubation medium there appears aggravation of the carbonyl stress as the result of growth of oxidative stress secondary markers content and exhausting of reserve-adaptative resource. Activation of cathepsins L and H splenocytes takes place in response to oxidative modified proteins elaboration which is proved by our positive correlative conjunction.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Cathepsins B, L and H Splenocytes as the Secondary Antioxidant Systems in the Conditions of Carbonyl Stress
    AU  - Fomina Maria Alekseevna
    AU  - Abalenikhina Yulia Vladimirovna
    Y1  - 2015/01/27
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ab.20150301.12
    DO  - 10.11648/j.ab.20150301.12
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
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    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20150301.12
    AB  - In the conditions of synthesis of nitrogen oxide deficit` modelling there is a growth of carbonyl derived proteins due to basic aldehyde- and keton-dinitrophenylhydrazones. After adding L-NAME into the incubation medium there appears aggravation of the carbonyl stress as the result of growth of oxidative stress secondary markers content and exhausting of reserve-adaptative resource. Activation of cathepsins L and H splenocytes takes place in response to oxidative modified proteins elaboration which is proved by our positive correlative conjunction.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Ryazan State Medical University named after academician I.P. Pavlov, Ryazan, Russia

  • Ryazan State Medical University named after academician I.P. Pavlov, Ryazan, Russia

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