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Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population

Received: 7 August 2018     Accepted: 27 August 2018     Published: 27 September 2018
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Abstract

To investigate the correlation between ApoE gene polymorphism and cerebral infarction (CI) and cerebral hemorrhage (ICH) in Tibetan patients with cerebrovascular disease, and the distribution of ApoE genotype in Tibetan nationality. We collected 94 patients as the experimental group, which hospitalized in Qinghai Provincial People's Hospital, Guoluozhou People's Hospital and Qinghai University Affiliated Hospital, including 48 cases of cerebral infarction (mean age 61.39 ± 10.48 years); 46 cases of cerebral hemorrhage (mean age 63.17 ± 10.92 years), and 96 healthy Tibetan residents from the physical examination center of Qinghai Provincial People's Hospital as control group. The results showed that in In the Tibetan population, the CI group was the most common in the e3 alleles, with 48.0%, followed by e2 (37.5%) alleles, the rarest of which was e4 (14.6%). The most common one in ICH group were e2 (43.5%), e3 (45.7%) alleles, and the rarest one was e4 (10.9%). e3 was the most common allele in patients with Tibetan cerebrovascular disease. In the normal control group, e2 (49.0%) was the most common alleles, followed by e4 (33.3%), and e3 (17.7%). e3 allele may be a predisposing factor for cerebrovascular disease in Tibetan population. In Tibetan population, the majority alleles of ApoE were heterozygous E2/E3 and E2/E4, suggesting that hypoxia environment may be beneficial. The TG values in Tibetan populations varied among different alleles, suggesting that different alleles may influence lipid metabolism.

Published in Advances in Applied Physiology (Volume 3, Issue 1)
DOI 10.11648/j.aap.20180301.16
Page(s) 38-43
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Apolipoprotein E, Polymorphism, Cerebrovascular Disease

References
[1] Peters-Libeu CA, Newhouse Y, Hall SC, et al. Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solution [J]. J Lipid Res, 2007, 48(5):1035-1044. DOI: 10.1194/jlr.M600545-JLR200.
[2] Yuan Q., Xu H., Zhang C. Study on ApoE gene polymorphism in Naxi cerebral infarction patients in Yunnan. Journal of Clinical Neurology, 2012, 25(5):341-343.
[3] Jia L. Study on the Relationship between ApoE gene Polymorphism and Cerebral Infarction in Yi People in Yunnan [D] .. Kunming Medical University, 2013.
[4] Yu-ping S, Qing L, Qiu-yunW, JingH, LingT, HuaY, Study on the Relationship between Metabolic diseases and ApoE 2 alleles in Uygur people in XinJiang [J] .. China Public Health, 2010, 26(04): 417-418.
[5] Chowdhury, A. H., Yokoyama, T., Kokubo, Y., Zaman, M. M., Haque, A., & Tanaka, H. Apolipoprotein e genetic polymorphism and stroke subtypes in a bangladeshi hospital-based study. Journal of Epidemiology, 2001, 11(3), 131-138.
[6] Wang X. Diagnosis points of cerebral vascular disease. Journal of Chinese neurology, 1996, 29 (6): 379-380.
[7] Graffagnino, C., Gasecki, A. P., Doig, G. S., & Hachinski, V. C. The importance of family history in cerebrovascular disease. Stroke, 1994, 25 (8), 1599-1604.
[8] Masemola M L, Alberts M, Urdal P. Apolipoprotein Egenotypes and their relation to lipid levels in a ruralSouth African population. Scand J Public HealthSuppl . 2007, Aug; 69: 60-5.
[9] Kolovou, G., Daskalova, D., & Mikhailidis, D. P. Apolipoprotein e polymorphism and atherosclerosis. Angiology, 2003, 54 (1), 59-71.
[10] Zhu-qing JIN, Yong-sheng FAN, Jing DING, Mei CHEN, Wei FAN, & Guang-ji ZHANG, et al. Association of apolipoprotein e 4 polymorphism with cerebral infarction in chinese han population. Acta Pharmacologica Sinica, 2004, 25(3), 352-356.
[11] Gu, N., Feng, G., Jiang, S., Qian, Y., Wu, X., & Lin, S., et al. The frequency of apoe alleles in chinese population of han nationality. Chinese Journal of Medical Cenetics, 1996(1):8-10.
[12] Carrette, O., Burgess, J. A., Burkhard, P. R., Lang, C., Côte, M., & Rodrigo, N., et al. Changes of the cortex proteome and apolipoprotein e in transgenic mouse models of alzheimer's disease ☆. Journal of Chromatography B, 2006, 840(1), 1-9.
[13] Mccarron, M. O., Delong, D., & Alberts, M. J. Apoe genotype as a risk factor for ischemic cerebrovascular disease a meta-analysis. Neurology, 1999, 53(6), 1308-1311.
[14] Mahley, R. W., & Huang, Y. Apolipoprotein e: from atherosclerosis to alzheimer's disease and beyond. Current Opinion in Lipidology, 1999, 10(3), 207-217.
[15] Lin, S. K., Kao, J. T., Tsai, S. M., Tsai, L. Y., Lin, M. N., & Lai, C. J., et al. Association of apolipoprotein e genotypes with serum lipid profiles in a healthy population of taiwan. Annals of Clinical & Laboratory Science, 2004, 34(4), 443-448.
[16] Liu Q., Chen L., Tan X. Prospective study on ApoE genotype and cerebrovascular disease. China Journal of Molecular, 2009. 9(3):139-143.
[17] Ma F., Wu W., Wang F. Study on the polymorphism of Apolipoprotein e gene and the relationship between Lipid metabolism and ischemic stroke subtypes. Journal of Cardiac Cerebral Vascular Disease in China, 2006, 8(8):513-516.
[18] Fu Q., Zhou L., Tang M. Analysis of the relationship between Lipid e gene polymorphism and blood lipid level in male population. Journal of Jilin University(Medical Edition), 2015, 41(4):808-813.
[19] Sun D., Li L., Ma Q. Study on the relationship between Apolipoprotein e gene polymorphism and blood lipid and coronary heart disease. Liaoning Medical Journal, 2008, 22(1):7-11.
[20] Yuan Q., Xu H., Zhang C. Study on ApoE gene polymorphism in Naxi cerebral infarction patients in Yunnan. Journal of Clinical Neurology, 2012, 25(5):341-343.
[21] Lian, G. U., Li, S. U., Chen, Q., Liang, B., Qin, Y., & Xie, J., et al. Association between the apolipoprotein e gene polymorphism and ischemic stroke in chinese populations: new data and meta-analysis. Experimental & Therapeutic Medicine, 2013, 5(3), 853-859.
[22] Liu H., Wang Q., Guan Y. Study on Zaizhidanbai gene polymorphism in patients with cerebral infarction. Southeast Defence Medicine, 2012, 14(3):195-198.
[23] Lu H., Tian G., Wang J. Study on the relationship between ApoE gene polymorphism and cerebral hemorrhage. Tianjin Medicine, 2004, 32(12):734-736.
[24] Lin, H. F., Lai, C. L., Tai, C. T., Lin, R. T., & Liu, C. K. Apolipoprotein e polymorphism in ischemic cerebrovascular diseases and vascular dementia patients in taiwan. Neuroepidemiology, 2004, 23(3), 129-134.
[25] Giassakis, G., Veletza, S., Papanas, N., Heliopoulos, I., & Piperidou, H. Apolipoprotein e and first-ever ischaemic stroke in greek hospitalized patients. Journal of International Medical Research, 2007, 35(1), 127.
[26] Xie A., Zhang Y., Liu X. Meta analysis of the relationship between ApoE gene polymorphism and atherosclerosis cerebral infarction. Medical Innovation in China, 2016, 13(26):100-103.
[27] Liu Q., Chen L., an X. Prospective study on ApoE genotype and cerebrovascular disease. China Journal of Molecular, 2009, 9(3):139-143.
[28] Nakata, Y., Katsuya, T., Rakugi, H., Takami, S., Sato, N., & Kamide, K., et al. Polymorphism of angiotensin converting enzyme, angiotensinogen, and apolipoprotein e genes in a japanese population with cerebrovascular, disease. American Journal of Hypertension, 1997, 10(12), 1391-1395.
[29] Chowdhury, A. H., Yokoyama, T., Kokubo, Y., Zaman, M. M., Haque, A., & Tanaka, H. Apolipoprotein e genetic polymorphism and stroke subtypes in a bangladeshi hospital-based study. Journal of Epidemiology, 2001, 11(3), 131-138.
[30] Chatzistefanidis, D., Giannopoulos, S., Spengos, K., Vassilopoulou, S., Vemmos, K., & Dova, L., et al. Apolipoprotein e polymorphisms and ischaemic stroke: a two-center greek study. European Journal of Neurology, 2014, 21(8), 1083-1088.
[31] Misra, U. K., Kalita, J., & Somarajan, B. I. Recurrent intracerebral hemorrhage in patients with hypertension is associated with apoe gene polymorphism: a preliminary study. Journal of Stroke & Cerebrovascular Diseases, 2013, 22(6), 758-763.
Cite This Article
  • APA Style

    Weizhong Ji, Shizheng Wu, Qian Hou, Junming Luo. (2018). Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population. Advances in Applied Physiology, 3(1), 38-43. https://doi.org/10.11648/j.aap.20180301.16

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    ACS Style

    Weizhong Ji; Shizheng Wu; Qian Hou; Junming Luo. Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population. Adv. Appl. Physiol. 2018, 3(1), 38-43. doi: 10.11648/j.aap.20180301.16

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    AMA Style

    Weizhong Ji, Shizheng Wu, Qian Hou, Junming Luo. Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population. Adv Appl Physiol. 2018;3(1):38-43. doi: 10.11648/j.aap.20180301.16

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  • @article{10.11648/j.aap.20180301.16,
      author = {Weizhong Ji and Shizheng Wu and Qian Hou and Junming Luo},
      title = {Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population},
      journal = {Advances in Applied Physiology},
      volume = {3},
      number = {1},
      pages = {38-43},
      doi = {10.11648/j.aap.20180301.16},
      url = {https://doi.org/10.11648/j.aap.20180301.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20180301.16},
      abstract = {To investigate the correlation between ApoE gene polymorphism and cerebral infarction (CI) and cerebral hemorrhage (ICH) in Tibetan patients with cerebrovascular disease, and the distribution of ApoE genotype in Tibetan nationality. We collected 94 patients as the experimental group, which hospitalized in Qinghai Provincial People's Hospital, Guoluozhou People's Hospital and Qinghai University Affiliated Hospital, including 48 cases of cerebral infarction (mean age 61.39 ± 10.48 years); 46 cases of cerebral hemorrhage (mean age 63.17 ± 10.92 years), and 96 healthy Tibetan residents from the physical examination center of Qinghai Provincial People's Hospital as control group. The results showed that in In the Tibetan population, the CI group was the most common in the e3 alleles, with 48.0%, followed by e2 (37.5%) alleles, the rarest of which was e4 (14.6%). The most common one in ICH group were e2 (43.5%), e3 (45.7%) alleles, and the rarest one was e4 (10.9%). e3 was the most common allele in patients with Tibetan cerebrovascular disease. In the normal control group, e2 (49.0%) was the most common alleles, followed by e4 (33.3%), and e3 (17.7%). e3 allele may be a predisposing factor for cerebrovascular disease in Tibetan population. In Tibetan population, the majority alleles of ApoE were heterozygous E2/E3 and E2/E4, suggesting that hypoxia environment may be beneficial. The TG values in Tibetan populations varied among different alleles, suggesting that different alleles may influence lipid metabolism.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Relationship Between ApoE Gene Polymorphism and Cerebrovascular Disease in Qinghai Tibetan Population
    AU  - Weizhong Ji
    AU  - Shizheng Wu
    AU  - Qian Hou
    AU  - Junming Luo
    Y1  - 2018/09/27
    PY  - 2018
    N1  - https://doi.org/10.11648/j.aap.20180301.16
    DO  - 10.11648/j.aap.20180301.16
    T2  - Advances in Applied Physiology
    JF  - Advances in Applied Physiology
    JO  - Advances in Applied Physiology
    SP  - 38
    EP  - 43
    PB  - Science Publishing Group
    SN  - 2471-9714
    UR  - https://doi.org/10.11648/j.aap.20180301.16
    AB  - To investigate the correlation between ApoE gene polymorphism and cerebral infarction (CI) and cerebral hemorrhage (ICH) in Tibetan patients with cerebrovascular disease, and the distribution of ApoE genotype in Tibetan nationality. We collected 94 patients as the experimental group, which hospitalized in Qinghai Provincial People's Hospital, Guoluozhou People's Hospital and Qinghai University Affiliated Hospital, including 48 cases of cerebral infarction (mean age 61.39 ± 10.48 years); 46 cases of cerebral hemorrhage (mean age 63.17 ± 10.92 years), and 96 healthy Tibetan residents from the physical examination center of Qinghai Provincial People's Hospital as control group. The results showed that in In the Tibetan population, the CI group was the most common in the e3 alleles, with 48.0%, followed by e2 (37.5%) alleles, the rarest of which was e4 (14.6%). The most common one in ICH group were e2 (43.5%), e3 (45.7%) alleles, and the rarest one was e4 (10.9%). e3 was the most common allele in patients with Tibetan cerebrovascular disease. In the normal control group, e2 (49.0%) was the most common alleles, followed by e4 (33.3%), and e3 (17.7%). e3 allele may be a predisposing factor for cerebrovascular disease in Tibetan population. In Tibetan population, the majority alleles of ApoE were heterozygous E2/E3 and E2/E4, suggesting that hypoxia environment may be beneficial. The TG values in Tibetan populations varied among different alleles, suggesting that different alleles may influence lipid metabolism.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Department of Neurology, Qinghai Provincial People’s Hospital, Xining, P. R. China

  • Department of Neurology, Qinghai Provincial People’s Hospital, Xining, P. R. China

  • Department of Neurology, Qinghai Provincial People’s Hospital, Xining, P. R. China

  • Department of Pathology, Qinghai Provincial People’s Hospital, Xining, P. R. China

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