Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case
International Journal of Clinical Oncology and Cancer Research
Volume 3, Issue 6, December 2018, Pages: 72-77
Received: Mar. 22, 2019;
Accepted: Apr. 28, 2019;
Published: May 27, 2019
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Emily Bryer DO, Department of Internal Medicine, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
David Henry MD, Department of Hematology and Oncology, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
Gestational trophoblastic tumors are a heterogeneous and aggressive group of neoplasms. Choriocarcinoma, an extremely rare subset of gestational trophoblastic tumor, is often metastatic at diagnosis and typically follows a pregnancy that is either ectopic or molar. We present a critical review of choriocarcinomas with an emphasis on choriocarcinomas of ovarian origin which are even more uncommon with an incidence estimated at 1 per 369 million. This manuscript also includes a case of a woman with polycystic ovarian syndrome who required assisted conception to conceive her daughter and then developed a rare extrauterine gestational ovarian choriocarcinoma eighteen months following her antecedent healthy pregnancy with uncomplicated delivery. Many aspects of this presentation are unique, even for such an extraordinary tumor; some of these include the absence of vaginal bleeding, the presence of unilateral pulmonary metastases, and an overwhelmingly positive serum β-hCG with a negative urine β-hCG. While such a discrepancy in urine and serum β-hCG has been reported in gestational trophoblastic disease following molar pregnancies, to our knowledge it has not yet been reported in choriocarcinomas following a normal pregnancy.
Emily Bryer DO,
David Henry MD,
Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case, International Journal of Clinical Oncology and Cancer Research.
Vol. 3, No. 6,
2018, pp. 72-77.
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