A Rare Case of Neck Metastasis from a Thyroid Papillary Carcinoma After Seventeen Years Diagnosed with US-Guided Fine Needle Aspiration Cytology
International Journal of Clinical Oncology and Cancer Research
Volume 2, Issue 5, October 2017, Pages: 106-109
Received: Jul. 21, 2017;
Accepted: Aug. 16, 2017;
Published: Sep. 7, 2017
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Stefania Erra, Department of Surgical Pathology, Santo Spirito Hospital, Casale Monferrato (Al), Italy
Antonella Lancella, Department of Otorhinolaryngology, Santo Spirito Hospital, Casale Monferrato (Al), Italy
Jessica Rotella, Student in Biology, University of Oriental Piedmont, Alessandria, Italy
Simona Ricotta, Student in Biology, University of Oriental Piedmont, Alessandria, Italy
Eleonora Mazzoni, Department of Surgical Pathology, Santo Spirito Hospital, Casale Monferrato (Al), Italy
Eugenio Carlon, Department of Radiology, Santo Spirito Hospital, Casale Monferrato (Al), Italy
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Thyroid papillary carcinoma represents a quite indolent and relatively frequent malignant tumor of the thyroid gland. Most lesions have a good prognosis, with excellent disease-free survival after thyroidectomy [1-3]. In this report it’s described a case of papillary carcinoma metastases with onset after 17 years from the first intervention. Some speculations are made regarding the reasons of the particular course of papillary carcinoma in this female patient. Clinical and anamnestic conditions together with B-RAF V600E point mutation could be responsible of a more aggressive biological potential.
Thyroid, Papillary Carcinoma, Aspiration Cytology
To cite this article
A Rare Case of Neck Metastasis from a Thyroid Papillary Carcinoma After Seventeen Years Diagnosed with US-Guided Fine Needle Aspiration Cytology, International Journal of Clinical Oncology and Cancer Research.
Vol. 2, No. 5,
2017, pp. 106-109.
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
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Giordano D et al. Lateral neck recurrence from papillary thyroid carcinoma: Predictive factors and prognostic significance. Laryngoscope. 2015 Sep; 125(9): 2226-31. doi: 10.1002/lary.25094.
Calò PG et al. Total thyroidectomy alone versus ipsilateral versus bilateral prophylactic central neck dissection in clinically node-negative differentiated thyroid carcinoma. A retrospective multicenter study. Eur J Surg Oncol. 2017 Jan; 43(1): 126-132. doi: 10.1016/j.ejso.2016.09.017.
Kim H et al. Patterns of Initial Recurrence in Completely Resected Papillary Thyroid Carcinoma. Thyroid. 2017 Jul; 27(7): 908-914. doi: 10.1089/thy.2016.0648.
Pisello F et al. Neck node dissection in thyroid cancer. A review. G Chir Vol. 31 - n. 3 - pp. 112-118, 2010.
Kim JW et al. Extent of Extrathyroidal Extension as a Significant Predictor of Nodal Metastasis and Extranodal Extension in Patients with Papillary Thyroid Carcinoma. Ann Surg Oncol. 2017 Feb; 24(2): 460-468. doi: 10.1245/s10434-016-5594-4.
Feng-Hsuan Liu et al. Postoperative recurrence of papillary thyroid carcinoma with lymph node metastasis. J Surg Oncol. 2015 Aug 1; 112(2): 149–154.
Kam-Tsun T. et al. BRAF Mutation in Papillary Thyroid Carcinoma: Pathogenic Role and Clinical Implications. J Chin Med Assoc • March 2010 • Vol 73 • No 3.
Chuping L et al. Associations between BRAFV600E and prognostic factors and poor outcomes in papillary thyroid carcinoma: a meta-analysis. World J Surg Oncol. 2016; 14(1): 241.
Walts A. E. BRAF genetic heterogeneity in papillary thyroid carcinoma and its metastasis. Hum Pathol. 2014 May; 45(5): 935-41. doi: 10.1016/j.humpath.2013.12.005.
Chereau N. et al. Prognosis of papillary thyroid carcinoma in elderly patients after thyroid resection. A retrospective cohort analysis. Medicine (2016) 95: 47(e5450).