Reconstructive Angioplasty During Secondary Cytoreductive Surgery Performed in Patients with Recurrent Ovarian Cancer
International Journal of Clinical Oncology and Cancer Research
Volume 2, Issue 3, June 2017, Pages: 51-56
Received: Jan. 27, 2017; Accepted: Apr. 11, 2017; Published: May 18, 2017
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Boyko Valeriy, State Institution «Zaitsev V. T. Institute of General and Emergent Surgery of the National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine
Kharchenko Kateryna, Kyiv City Clinical Oncology Centre, Kyiv, Ukraine
Prasol Vitaliy, State Institution «Zaitsev V. T. Institute of General and Emergent Surgery of the National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine
Uderbayeva Gukmira, City Clinical Oncology Centre of Astana Akimat, Astana, Kazakhstan
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Background: Tumor involvement of major vessels, especially the iliac arteries, is used to be the significant limitation for secondary cytoreductive surgery (SCRS) of recurrent ovarian cancer (ROC). Materials and Methods: Patients with ROC (n=46) who were treated in the State Establishment «Zaitsev V. T. Institute of General and Emergent Surgery of the Academy of Medical Sciences of Ukraine» during January 2009 – September 2015. All patients received SCRS with restoration and reconstructive angioplasty of the external iliac artery: I group (n=24) – alloprosthesis; II group (n=22) – autoartery angioplasty. Results: Duration of surgery was in Group I and Group II 466.3±11.2 min vs 454.8±10.3 min respectively, р>0.05. Postoperative complications occurred in 10 (21.7%) patients (25% in Group I; 18.2% in Group II). The incidence of nonspecific early postoperative complications was 25% in Group I and 19.1% in Group II; p=0.3. The incidence of specific complications was higher in allograft group (12.3% vs 4.5%; р=0.036). There was statistically significant difference between the groups in stage distribution of postoperative complications (р=0.03). There were no cases of late specific and non-specific complications. Postoperative mortality was 0%. Duration of hospital stay in Group I was 21.5±2.3 days vs 12.1±1.7 days; in Group II, p=0.02. SCRS was optimal in all cases. Median follow-up was 42.5 months (range 7-64 months). There was no significant difference among groups in the recurrence rate, medians disease-free and overall survival. Conclusion: Usage of the internal iliac artery as autograft during SCRS with restoration and reconstruction angioplasty of external iliac artery leads to reducing risk of specific complications (infection, rejection) and prevents development of destructive processes in the graft wall. There is no negative impact of such surgical approach on the rates of recurrence and overall survival of ROC patients.
Ovarian Cancer, Recurrence, Treatment, Secondary Cytoreductive Surgery, Angioplasty
To cite this article
Boyko Valeriy, Kharchenko Kateryna, Prasol Vitaliy, Uderbayeva Gukmira, Reconstructive Angioplasty During Secondary Cytoreductive Surgery Performed in Patients with Recurrent Ovarian Cancer, International Journal of Clinical Oncology and Cancer Research. Vol. 2, No. 3, 2017, pp. 51-56. doi: 10.11648/j.ijcocr.20170203.11
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