Effect of Black Tea on Micronuclei (Oral Cancer Biomarker) Among Indian Population
International Journal of Clinical Oncology and Cancer Research
Volume 2, Issue 1, February 2017, Pages: 7-9
Received: Dec. 10, 2016;
Accepted: Feb. 3, 2017;
Published: Feb. 27, 2017
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Aniket Adhikari, Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata, India
Madhusnata De, Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata, India
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Introduction Tea is the most widely consumed beverage worldwide and important agricultural product. Being rich in natural antioxidants, tea is used in the management of different types of cancers including oral cavity. Micronuclei (MN) act as a biomarker for oral cancer. These are small, extra nuclear bodies that are formed during mitosis from lagging chromosomes. The micronucleus test is used as a tool for genotoxicity. In this present study subjects were screened from Department of E. N. T. & Oral and Maxillofacial surgery of RKMSP hospital, Kolkata and different areas of Eastern and North Eastern states of India. Exfoliated cell were examined from buccal mucosa for MN. Percentage of MN was low after black tea supplementation. We can concluded that betel quid has an immense role in changing the oral pathology and tea has chemo preventive property.
Black Tea, Cancer, Polyphenols, Micronuclei, Betel Quid
To cite this article
Effect of Black Tea on Micronuclei (Oral Cancer Biomarker) Among Indian Population, International Journal of Clinical Oncology and Cancer Research.
Vol. 2, No. 1,
2017, pp. 7-9.
Copyright © 2017 Authors retain the copyright of this article.
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Gutman RL, Ryu BH. Rediscovering tea. An exploration of the scientific literature. Herbal Gram.1996; 37: 33.
Gupta S et al. Anticlastogenic effects of black tea (World Blend) and its two active polyphenols theaflavins and thearubigins in vivo in Swiss albino mice. Life Sci 2001; 69: 2735.
Braicu C et al. Epigallocatechin-3-Gallate (EGCG) inhibits cellproliferation and migratory behaviour of triple negative breast cancer cells. J Nanosci Nanotechnol 2013; 13: 632-637.
Sukhthankar M et al. A green tea component suppresses post translational expression of basic fibroblast growth factor in colorectal cancer. Gastroenterology 2008; 134: 1972-1980.
Williams HK. Molecular pathogenesis of oral squamous carcinoma. Molecular Pathology 2000; 53 (4): 165–172.
Jemal A et al. Cancer statistics, 2009. CA Cancer Journal for Clinicians 2009; 59 (4): 225–249.
Parkin DM et al. Estimates of the worldwide frequency of sixteen major cancers in 1980. International Journal of Cancer 1988; 41 (2): 184–97.
Weisburger JH. Antimutagens, anticarcinogens and effective worldwide cancer prevention. J Environ Pathol Toxicol Oncol 1999; 18: 85–93.
Blozis GG. The value of exfoliative cytology in the diagnosis of oral cancer. Int Dent J 1972; 22 (4): 481-486.
Genetic toxicity. www. cerep.fr/genotoxicity.pdf.january 2007.
Casartelli G et al. Micronucleus frequencies in exfoliated buccal cells in normal mucosa, precancerous lesions and squamous cell carcinoma. Anal Quant Cytol Histol 2000; 22: 486–92.