Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer
International Journal of Clinical Oncology and Cancer Research
Volume 1, Issue 1, December 2016, Pages: 36-41
Received: Dec. 20, 2016; Accepted: Dec. 30, 2016; Published: Jan. 17, 2017
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Ahmed Mohammed Morsy, Pediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
Eman Ahmed Hasan, Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
Ameer Mohammed Abuelgheet, Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt
Ahmed Salaheldeen Hassan, Pediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
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Environmentally-induced epigenetic changes of gene regulation could result from chronic, lifelong exposure, to low doses of environmental toxicants, such as chemicals including, tobacco smoking and endocrine disrupting compounds, or to other environmental factors such as nutritional changes, and lifestyle-related conditions. These environmentally-acquired epigenetic marks may influence the control of gene regulation through DNA methylation, histone modification, or through a large set of non-coding RNAs (ncRNAs). These epigenetic effects might be passed on to the developing embryo and child as inheritable non-genetic marks, which recapitulate previous lifelong history of exposure to environmental influences that start from the stage of primordial germ cell, passing through the maturing germ cell, and ending by the zygote stage. This involves the paternally transmitted information on the sperm that contribute to modulating embryogenesis functions and later childhood development, in concert with, the maternally transmitted information encountered by the exposure to a large milieu of environmental factors either periconceptionally or during lactation period.
Pediatric Oncology, Childhood Cancer, Epigenetics, Environmental Exposures, Epigenetic Inheritance & Evolution, Pediatric Cancer Susceptibility
To cite this article
Ahmed Mohammed Morsy, Eman Ahmed Hasan, Ameer Mohammed Abuelgheet, Ahmed Salaheldeen Hassan, Environmentally-Mediated Epigenetic Effects: Uncovering the Fertile Soil in the Development of Pediatric Cancer, International Journal of Clinical Oncology and Cancer Research. Vol. 1, No. 1, 2016, pp. 36-41. doi: 10.11648/j.ijcocr.20160101.16
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Ross, P. J. and S. Canovas, Mechanisms of epigenetic remodelling during preimplantation development. Reproduction, Fertility and Development, 2016. 28 (2): p. 25-40.
Cantone, I. and A. G. Fisher, Epigenetic programming and reprogramming during development. Nature structural & molecular biology, 2013. 20 (3): p. 282-289.
Jenkins, T. G. and D. T. Carrell, The paternal epigenome and embryogenesis: poising mechanisms for development. Asian J Androl, 2011. 13 (1): p. 76-80.
Jenkins, T. and D. T. Carrell, Sperm specific chromatin modifications and their impact on the paternal contribution to the embryo. Reproduction, 2012: p. REP-11-0450.
Jenkins, T. G. and D. T. Carrell, The sperm epigenome and potential implications for the developing embryo. Reproduction, 2012. 143 (6): p. 727-734.
Sharma, S., T. K. Kelly, and P. A. Jones, Epigenetics in cancer. Carcinogenesis, 2010. 31 (1): p. 27-36.
Jiménez-Chillarón, J. C., et al., Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling. Epigenetics, 2015. 10 (4): p. 259-273.
Skinner, M. K., C. Guerrero-Bosagna, and M. M. Haque, Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations. Epigenetics, 2015. 10 (8): p. 762-771.
Papazyan, R., Y. Zhang, and M. A. Lazar, Genetic and epigenomic mechanisms of mammalian circadian transcription. Nature structural & molecular biology, 2016. 23 (12): p. 1045-1052.
Marchlewicz, E. H., et al., Lipid metabolism is associated with developmental epigenetic programming. Scientific Reports, 2016. 6.
Joubert, B. R., et al., Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns. Nature communications, 2016. 7.
Banderali, G., et al., Short and long term health effects of parental tobacco smoking during pregnancy and lactation: a descriptive review. Journal of translational medicine, 2015. 13 (1): p. 1.
Rios, P., et al., Risk of neuroblastoma, birth-related characteristics, congenital malformations and perinatal exposures: A pooled analysis of the ESCALE and ESTELLE French studies (SFCE). International Journal of Cancer, 2016. 139 (9): p. 1936-1948.
Greaves, M., Aetiology of acute leukaemia. The Lancet, 1997. 349 (9048): p. 344-349.
Alsaweed, M., et al., Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk. Scientific Reports, 2016. 6.
Morandini, A. C., C. F. Santos, and Ö. Yilmaz, Role of epigenetics in modulation of immune response at the junction of host–pathogen interaction and danger molecule signaling. Pathogens and Disease, 2016. 74 (7): p. ftw082.
Timms, J. A., et al., DNA methylation as a potential mediator of environmental risks in the development of childhood acute lymphoblastic leukemia. Epigenomics, 2016. 8 (4): p. 519-536.
Joubert, B. R., et al., Maternal smoking and DNA methylation in newborns: in utero effect or epigenetic inheritance? Cancer Epidemiology Biomarkers & Prevention, 2014. 23 (6): p. 1007-1017.
Joubert, B. R., et al., 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environmental health perspectives, 2012. 120 (10): p. 1425.
Evans, T.-J., et al., Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures. PloS one, 2014. 9 (10): p. e110255.
McKay, J. A., et al., Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B 12. PloS one, 2012. 7 (3): p. e33290.
Metayer, C., et al., Maternal supplementation with folic acid and other vitamins and risk of leukemia in offspring: a childhood leukemia international consortium study. Epidemiology, 2014. 25 (6): p. 811-822.
Kamper-Jørgensen, M., et al., Childcare in the first 2 years of life reduces the risk of childhood acute lymphoblastic leukemia. Leukemia, 2008. 22 (1): p. 189-193.
Orsi, L., et al., Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy, and childhood acute leukemia: the ESTELLE study. Cancer Causes & Control, 2015. 26 (7): p. 1003-1017.
Yan, K., et al., The associations between maternal factors during pregnancy and the risk of childhood acute lymphoblastic leukemia: A meta-analysis. Pediatric blood & cancer, 2015. 62 (7): p. 1162-1170.
Ping, J., et al., Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Toxicology, 2014. 321: p. 53-61.
Cheng, J., et al., Maternal coffee consumption during pregnancy and risk of childhood acute leukemia: a metaanalysis. American journal of obstetrics and gynecology, 2014. 210 (2): p. 151. e1-151. e10.
Chokkalingam, A. P., et al., Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemia. Cancer Causes & Control, 2012. 23 (8): p. 1367-1375.
Scélo, G., et al., Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environmental health perspectives, 2009. 117 (1): p. 133.
Ma, X., et al., Critical windows of exposure to household pesticides and risk of childhood leukemia. Environmental health perspectives, 2002. 110 (9): p. 955.
Van Maele-Fabry, G., et al., Residential exposure to pesticides and childhood leukaemia: a systematic review and meta-analysis. Environment international, 2011. 37 (1): p. 280-291.
Kennedy, A. E., et al., Examination of HFE associations with childhood leukemia risk and extension to other iron regulatory genes. Leukemia research, 2014. 38 (9): p. 1055-1060.
Peters, S., et al., Parental occupational exposure to engine exhausts and childhood brain tumors. International Journal of Cancer, 2013. 132 (12): p. 2975-2979.
Malarkey, D. E., M. Hoenerhoff, and R. R. Maronpot, Carcinogenesis: Mechanisms and manifestations. Haschek and Rousseaux’s handbook of toxicologic pathology (WM Haschek, CG Rousseaux, and MA Wallig, eds.), 2013: p. 107.
Scotting, P. J., D. A. Walker, and G. Perilongo, Childhood solid tumours: a developmental disorder. Nature Reviews Cancer, 2005. 5 (6): p. 481-488.
Moore, S. W., Developmental genes and cancer in children. Pediatric blood & cancer, 2009. 52 (7): p. 755-760.
Ohnishi, K., K. Semi, and Y. Yamada, Epigenetic regulation leading to induced pluripotency drives cancer development in vivo. Biochemical and biophysical research communications, 2014. 455 (1): p. 10-15.
Carmel-Gross, I., et al., LIN28: A Stem Cell Factor with a Key Role in Pediatric Tumor Formation. Stem cells and development, 2015. 25 (5): p. 367-377.
Ohnishi, K., et al., Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell, 2014. 156 (4): p. 663-677.
Urbach, A., et al., Lin28 sustains early renal progenitors and induces Wilms tumor. Genes & development, 2014. 28 (9): p. 971-982.
Lambertini, L., Genomic imprinting: sensing the environment and driving the fetal growth. Current opinion in pediatrics, 2014. 26 (2): p. 237-242.
Soejima, H. and K. Higashimoto, Epigenetic and genetic alterations of the imprinting disorder Beckwith–Wiedemann syndrome and related disorders. Journal of human genetics, 2013. 58 (7): p. 402-409.
Bjornsson, H. T., M. D. Fallin, and A. P. Feinberg, An integrated epigenetic and genetic approach to common human disease. TRENDS in Genetics, 2004. 20 (8): p. 350-358.
Peaston, A. E. and E. Whitelaw, Epigenetics and phenotypic variation in mammals. Mammalian Genome, 2006. 17 (5): p. 365-374.
Feinberg, A. P., Genome-scale approaches to the epigenetics of common human disease. Virchows Archiv, 2010. 456 (1): p. 13-21.
Skinner, M. K., M. Manikkam, and C. Guerrero-Bosagna, Epigenetic transgenerational actions of environmental factors in disease etiology. Trends in Endocrinology & Metabolism, 2010. 21 (4): p. 214-222.
Nilsson, E. E. and M. K. Skinner, Environmentally induced epigenetic transgenerational inheritance of disease susceptibility. Translational Research, 2015. 165 (1): p. 12-17.
Plass, C., et al., Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer. Nature reviews genetics, 2013. 14 (11): p. 765-780.
Lawlor, E. R. and C. J. Thiele, Epigenetic changes in pediatric solid tumors: promising new targets. Clinical Cancer Research, 2012. 18 (10): p. 2768-2779.
McKenna, E. S. and C. W. Roberts, Epigenetics and cancer without genomic instability. Cell Cycle, 2009. 8 (1): p. 23-26.
Wilson, B. G., et al., Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer cell, 2010. 18 (4): p. 316-328.
Guerrero-Bosagna, C., P. Sabat, and L. Valladares, Environmental signaling and evolutionary change: can exposure of pregnant mammals to environmental estrogens lead to epigenetically induced evolutionary changes in embryos? Evolution & development, 2005. 7 (4): p. 341-350.
Angers, B., E. Castonguay, and R. Massicotte, Environmentally induced phenotypes and DNA methylation: how to deal with unpredictable conditions until the next generation and after. Molecular Ecology, 2010. 19 (7): p. 1283-1295.
Feinberg, A. P., R. Ohlsson, and S. Henikoff, The epigenetic progenitor origin of human cancer. Nature reviews genetics, 2006. 7 (1): p. 21-33.
Hochberg, Z. e., et al., Child health, developmental plasticity, and epigenetic programming. Endocrine Reviews, 2010. 32 (2): p. 159-224.
Meacham, C. E. and S. J. Morrison, Tumour heterogeneity and cancer cell plasticity. Nature, 2013. 501 (7467): p. 328-337.
Easwaran, H., H.-C. Tsai, and S. B. Baylin, Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Molecular cell, 2014. 54 (5): p. 716-727.
Yamamoto, K., et al., Spontaneous regression of localized neuroblastoma detected by mass screening. Journal of Clinical Oncology, 1998. 16 (4): p. 1265-1269.
Greger, V., et al., Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Human genetics, 1989. 83 (2): p. 155-158.
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