The Simple and Efficient Method of Synthesis of Amino Pyrimidine and Their Derivatives
Sirsat Shivraj,
Bobade Dnyaneshwar,
Shinde Sainath
Issue:
Volume 8, Issue 1, June 2022
Pages:
1-6
Received:
22 March 2022
Accepted:
21 April 2022
Published:
31 May 2022
DOI:
10.11648/j.ajhc.20220801.11
Downloads:
Views:
Abstract: In the literature survey others reported a variety of synthesis of Pyrimido pyrimidine and their derivatives that have been potential bioactive molecules. Hence, they have to drag considerable attention in the synthesis of biologically active molecule and advanced organic chemistry. In the group of heterocyclic compounds nitrogen containing heterocycles are an important class of compounds in the medicinal chemistry and also contributed to the society from biological, industrial and pharmacological applications such as anticonvulsant, antihypertensive aactivity, analgesic, anti-depressive, antipyretic, anti-inflammatory, Chemotherapeutic agents, antiviral, anti-HIV, antimicrobial and anti-tumour activities. Therefore, the present study aim to investigate the chemistry of heterocycles incorporating 4,11-diimino-2,9-bis(methylthio)-6-hydroxy-7,11-dihydro-4H,6H-dipyrimido[1,2-a:1',2'-c]pyrimidine-3,10-dicarbonitrile skeletons and their derivatives. The simple and efficient synthesis of amino pyrimidine have been demonstrated by using Michael addition reaction, Michael acceptor ethylecyano acetate and Michael donor guanidine nitrate. The resulting compound 2,6 diamino 4-hydroxy pyrimidine was further reacted with 2-[bis (methylthio)methylene]malononitrile in the presence of catalytic amount of K2CO3 in DMF under reflux condition that offered substituted amino pyrimidine. In the compound of amino pyrimidine have replaceable methylthio group, This group are substituted by various nucleophiles such as various substituted aromatic amines, aromatic phenols, heteryl amines and active methylene compounds. The structure and formula of all the synthesized compounds were characterized by spectral data. Some of the synthesized compounds were evaluated for their biological activities. The compounds of this class of heterocycles containing a significant characteristic scaffold and possessing a wide range of biological characteristic.
Abstract: In the literature survey others reported a variety of synthesis of Pyrimido pyrimidine and their derivatives that have been potential bioactive molecules. Hence, they have to drag considerable attention in the synthesis of biologically active molecule and advanced organic chemistry. In the group of heterocyclic compounds nitrogen containing heteroc...
Show More
Deep Eutectic Solvent a Highly Efficient Medium for the Synthesis of Imidazo [1, 2-a] Pyridines Having Green Chemistry Approach
Majid Shaikh,
Sayyad Sultan Kasim
Issue:
Volume 8, Issue 1, June 2022
Pages:
7-11
Received:
30 August 2022
Accepted:
27 September 2022
Published:
28 October 2022
DOI:
10.11648/j.ajhc.20220801.12
Downloads:
Views:
Abstract: The imidazo [1, 2-a] pyridine is valuable structural unit in the area of natural products and pharmaceuticals. Extremely effective one pot method developed for the production of imidazo [1, 2-a] pyridines. The reaction of N-bromosuccinimide, acetophenones and 2-aminopyridines in deep eutectic solvent and reaction completed within a minute. The most remarkable features of such reaction is lowest minimum time, high atom, mild reaction condition and step economy. Methods The mixture of substituted acetophenones, N-bromosuccinimide in deep eutectic solvent as a green medium and 2-aminopyridines. The optimization of the reaction conditions with regard to their chemo selectivity of deep eutectic solvent. An imidazopyridine is a nitrogen containing heterocycle which plays crucial role in medicinal and pharmacological chemistry. Results To synthesize the imidazo [1, 2-a] pyridines, In the deep eutectic solvents add N-bromosuccinimide, acetophenones at room temperature immediately reaction completed within a minute, TLC Shows single spot which indicate that formation of α- bromoketones. On formation of α- bromoketones; 2-aminopyridine was added in the reaction mass after completion of reaction, the reaction mixture was poured in ice-cold water; the solid product obtained was filtered. Conclusion The main remarkable characteristics of this protocol such as no need to isolate lachrymatric α-bromoketones, clean reaction profile, mild reaction condition, require minimum reaction time, inexpensive and green aspects such as avoid hazardous solvents, poisonous catalyst, higher yield and ease of work-up.
Abstract: The imidazo [1, 2-a] pyridine is valuable structural unit in the area of natural products and pharmaceuticals. Extremely effective one pot method developed for the production of imidazo [1, 2-a] pyridines. The reaction of N-bromosuccinimide, acetophenones and 2-aminopyridines in deep eutectic solvent and reaction completed within a minute. The most...
Show More
