Correlation Between Current Histopathological Grading and Clinical Features of Mucoepidermoid Carcinoma of the Salivary Glands
Shaheen Ahamed,
Mohammad Morshed Alam,
Sumanta Kumar Gain,
Niaz Ahmed,
Mausumi Iqbal
Issue:
Volume 8, Issue 2, December 2022
Pages:
45-49
Received:
11 August 2022
Accepted:
27 September 2022
Published:
30 November 2022
DOI:
10.11648/j.ijdm.20220802.11
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Abstract: Mucoepidermoid carcinoma (MEC) is a salivary malignancy with a widely diverse biologic behavior. Mucoepidermoid tumors are the one malignancy in which histologic grading and clinical behavior characteristics correlate. It is the most common among the different types of salivary gland cancer. Usually, these cancers are low-grade in nature but can realize into intermediate or high grade. The biological outcome of such cancer cases can be predicted using clinical and histological grading. The aim of the present study was to observe and evaluate the correlation between histopathological grading and clinical features of mucoepidermoid carcinoma of salivary glands, to determine whether an accurate diagnosis can be made based primarily on clinical findings. This observational descriptive cross-sectional multi-center study was conducted at the Department of Oral and Maxillofacial Surgery, Dhaka Dental College Hospital, Dhaka, Department of Otolaryngology &Head Neck Surgery, Dhaka Medical College Hospital, Dhaka, and Department of Otolaryngology-Head Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study duration was 1.5 years, from July 2011 to December 2012. A total of 20 patients attending the study centers with diagnosed case of mucoepidermoid carcinoma of salivary glands was selected for the study following inclusion and exclusion criteria. 40% of the participants were from the age group of 31-40 years, while another 30% were under the age of 21 years. 70% of the participants were female. Histological grading of the participants revealed 8 low-grade, 8 intermediate grade, and 4 high-grade MEC tumor cases. High-grade tumor MEC had an association with increasing age and male gender. The swelling was a common clinical feature among all the participants, whereas ulceration was observed in 75% of high-grade tumor patients. In mucoepidermoid carcinoma (MEC) of the salivary glands, it was suggested that the histopathological grade of MEC evaluated by Brandwein point-based histological grading schema significantly correlated with age, gender, and clinical features. These results suggest and emphasize that histological grading of MEC, as well as clinical features, should be considered when planning surgery for the MEC and the necessity of treatment outcome.
Abstract: Mucoepidermoid carcinoma (MEC) is a salivary malignancy with a widely diverse biologic behavior. Mucoepidermoid tumors are the one malignancy in which histologic grading and clinical behavior characteristics correlate. It is the most common among the different types of salivary gland cancer. Usually, these cancers are low-grade in nature but can re...
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