Abstract: Splenic rupture can be traumatic or non-traumatic (spontaneous). The spleen is the commonest solid organ injured in blunt abdominal injury. Spontaneous splenic rupture is rare and one cause of acute abdomen which can lead to morbidity and mortality. Among patients having spontaneous splenic rupture, majority of them have underlying splenic pathology of different causes such as hematologic, infectious, inflammatory, drugs or mechanical. In endemic area of malaria, spontaneous splenic rupture is one of fatal complication of severe malaria fortunately it is rare complication. In rare cases there may be no splenic pathology identified which is called idiopathic. The treatment of ruptured spleen is mainly splenectomy though there are cases reports of angioembolization as treatment option. Here we present a case report of 20 year old male patient who presented with diffuse abdominal pain of 3 days duration with signs of generalized peritonitis. During exploratory laparotomy, he was having ruptured spleen with blood in the peritoneum. He was managed with splenectomy and cross match transfusion after the bleeding was controlled. The patient was discharged improved after he took pentavalent vaccine. In conclusion, though spontaneous splenic rupture is rare over all there are different case reports of this condition and one has to consider it as differential diagnosis in patient who presented with acute abdomen of unclear causes and especially if the patient has underlying diseases or drugs that can affect the spleen.Abstract: Splenic rupture can be traumatic or non-traumatic (spontaneous). The spleen is the commonest solid organ injured in blunt abdominal injury. Spontaneous splenic rupture is rare and one cause of acute abdomen which can lead to morbidity and mortality. Among patients having spontaneous splenic rupture, majority of them have underlying splenic patholog...Show More
Abstract: Pedigree analysis is carried out to understand the mode of inheritance of a particular disease, which includes recessive, dominant, partial dominant, autosomal, mitochondrial or sex-linked etc. It also determines the individual’s probability of affecting in a given cross. Genetic disorders are transmitted from one generation to the next by following a particular inheritance pattern. Correct investigation of the transmission patterns of a trait under different circumstances is the crucial in genetic research. That is, identification of ancestry patterns for twins, full penetrance and reduced penetrance cases etc. This paper considers autosomal recessive case. Two simulated single nucleotide polymorphisms (SNPs) based genotype data sets for 14 and 47 individuals with three and four generations, respectively, were applied for this investigation. This evaluation looks for the probable features of ancestry patterns of a genetic disorder from one generation to the next based on the specified genetic conditions. Proper visualization of the pedigree charts for autosomal recessive case having different characteristics were demonstrated here. Since, sequencing of deoxyribonucleic acid (DNA), and handling of such massive amount of data depends on the availability of funding, dedicated software, high throughput data storage capacity etc. Hence, effective simulation for data generation would be the choice to cope with this situation for realizing the pipeline of such genetic research. The main objective of this paper is to provide a useful guideline for the introductory genetic researchers to whom real data sets are not available, and once available, dealing with this massive amount of sequencing data is a big challenge due to some limitations. This guideline will help to have an idea about such research. If opportunity is given, this idea could be applied for the real data sets, and the results would be similar.Abstract: Pedigree analysis is carried out to understand the mode of inheritance of a particular disease, which includes recessive, dominant, partial dominant, autosomal, mitochondrial or sex-linked etc. It also determines the individual’s probability of affecting in a given cross. Genetic disorders are transmitted from one generation to the next by followin...Show More
