In Prediabetes blood sugar levels are found to be higher than normal levels. It is considered as pre stage of diabetes as people with prediabetes, if remain undiagnosed, have chances of developing type 2 diabetes. Studies show that if diabetes is treated in the prediabetic stage, it results in complete cure of diabetes. The objective of the present study was to investigate effect of PDBT capsules containing extracts of well-known Ayurvedic plants such as Zingiber officinale, Tinospora cordifolia, Pterocarpus marsupium, Gymnema sylvester, and Momordica charantia on prediabetic condition induced in Wistar rats. High fat fructose diet was fed to male Wistar rats to induce prediabetes. After induction on 11th week of study, the prediabetic rats were divided in different groups. Treatment groups received Pioglitazone (3 mg/kg) (standard control), test formulation, PDBT capsule (200mg/kg) (test group) along with high fat fructose diet. Normal diet control group received normal diet and high fat fructose diet control group received only high fat fructose diet. The different biochemical parameters, blood glucose levels and body weights were monitored. Animals were sacrificed at the end of study period. Histopathological studies on the major organs such as liver, kidney, pancreas was performed. High fat fructose diet induced of prediabetes in rats. Significant decrease in levels of fasting blood glucose and biochemical parameters in treatment groups was observed. The histopathological study showed no abnormalities. The present research show that PDBT capsules can be efficiently used in prediabetes treatment. Hence, PDBT capsule can be a potential agent for the treatment of prediabetes.
| Published in | International Journal of Diabetes and Endocrinology (Volume 6, Issue 1) |
| DOI | 10.11648/j.ijde.20210601.14 |
| Page(s) | 16-23 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Prediabetes, Zingiber officinale, Tinospora cordifolia, Pterocarpus marsupium, Gymnema sylvester, Momordica charantia
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APA Style
Pallavi Londhe, Rohini Waghmare, Amit Nakanekar, Kuldip Kohli, Pratima Arun Tatke. (2021). Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes. International Journal of Diabetes and Endocrinology, 6(1), 16-23. https://doi.org/10.11648/j.ijde.20210601.14
ACS Style
Pallavi Londhe; Rohini Waghmare; Amit Nakanekar; Kuldip Kohli; Pratima Arun Tatke. Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes. Int. J. Diabetes Endocrinol. 2021, 6(1), 16-23. doi: 10.11648/j.ijde.20210601.14
AMA Style
Pallavi Londhe, Rohini Waghmare, Amit Nakanekar, Kuldip Kohli, Pratima Arun Tatke. Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes. Int J Diabetes Endocrinol. 2021;6(1):16-23. doi: 10.11648/j.ijde.20210601.14
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Download@article{10.11648/j.ijde.20210601.14,
author = {Pallavi Londhe and Rohini Waghmare and Amit Nakanekar and Kuldip Kohli and Pratima Arun Tatke},
title = {Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes},
journal = {International Journal of Diabetes and Endocrinology},
volume = {6},
number = {1},
pages = {16-23},
doi = {10.11648/j.ijde.20210601.14},
url = {https://doi.org/10.11648/j.ijde.20210601.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20210601.14},
abstract = {In Prediabetes blood sugar levels are found to be higher than normal levels. It is considered as pre stage of diabetes as people with prediabetes, if remain undiagnosed, have chances of developing type 2 diabetes. Studies show that if diabetes is treated in the prediabetic stage, it results in complete cure of diabetes. The objective of the present study was to investigate effect of PDBT capsules containing extracts of well-known Ayurvedic plants such as Zingiber officinale, Tinospora cordifolia, Pterocarpus marsupium, Gymnema sylvester, and Momordica charantia on prediabetic condition induced in Wistar rats. High fat fructose diet was fed to male Wistar rats to induce prediabetes. After induction on 11th week of study, the prediabetic rats were divided in different groups. Treatment groups received Pioglitazone (3 mg/kg) (standard control), test formulation, PDBT capsule (200mg/kg) (test group) along with high fat fructose diet. Normal diet control group received normal diet and high fat fructose diet control group received only high fat fructose diet. The different biochemical parameters, blood glucose levels and body weights were monitored. Animals were sacrificed at the end of study period. Histopathological studies on the major organs such as liver, kidney, pancreas was performed. High fat fructose diet induced of prediabetes in rats. Significant decrease in levels of fasting blood glucose and biochemical parameters in treatment groups was observed. The histopathological study showed no abnormalities. The present research show that PDBT capsules can be efficiently used in prediabetes treatment. Hence, PDBT capsule can be a potential agent for the treatment of prediabetes.},
year = {2021}
}
TY - JOUR T1 - Polyherbal Formulation (PDBT Capsules) Containing Extracts of Ayurvedic Plants for Treatment of Prediabetes AU - Pallavi Londhe AU - Rohini Waghmare AU - Amit Nakanekar AU - Kuldip Kohli AU - Pratima Arun Tatke Y1 - 2021/01/18 PY - 2021 N1 - https://doi.org/10.11648/j.ijde.20210601.14 DO - 10.11648/j.ijde.20210601.14 T2 - International Journal of Diabetes and Endocrinology JF - International Journal of Diabetes and Endocrinology JO - International Journal of Diabetes and Endocrinology SP - 16 EP - 23 PB - Science Publishing Group SN - 2640-1371 UR - https://doi.org/10.11648/j.ijde.20210601.14 AB - In Prediabetes blood sugar levels are found to be higher than normal levels. It is considered as pre stage of diabetes as people with prediabetes, if remain undiagnosed, have chances of developing type 2 diabetes. Studies show that if diabetes is treated in the prediabetic stage, it results in complete cure of diabetes. The objective of the present study was to investigate effect of PDBT capsules containing extracts of well-known Ayurvedic plants such as Zingiber officinale, Tinospora cordifolia, Pterocarpus marsupium, Gymnema sylvester, and Momordica charantia on prediabetic condition induced in Wistar rats. High fat fructose diet was fed to male Wistar rats to induce prediabetes. After induction on 11th week of study, the prediabetic rats were divided in different groups. Treatment groups received Pioglitazone (3 mg/kg) (standard control), test formulation, PDBT capsule (200mg/kg) (test group) along with high fat fructose diet. Normal diet control group received normal diet and high fat fructose diet control group received only high fat fructose diet. The different biochemical parameters, blood glucose levels and body weights were monitored. Animals were sacrificed at the end of study period. Histopathological studies on the major organs such as liver, kidney, pancreas was performed. High fat fructose diet induced of prediabetes in rats. Significant decrease in levels of fasting blood glucose and biochemical parameters in treatment groups was observed. The histopathological study showed no abnormalities. The present research show that PDBT capsules can be efficiently used in prediabetes treatment. Hence, PDBT capsule can be a potential agent for the treatment of prediabetes. VL - 6 IS - 1 ER -
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