Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder characterized by rapidly progressive dementia and myoclonus. Additional clinical features include visual disturbances, cerebellar, and pyramidal/extrapyramidal signs. The rarity of this disease and the wide variety of initial symptoms make the early diagnosis quite challenging. Nevertheless, it can also be diagnosed in a centre with limited resources through good clinical analysis. Here a case of a 53-year-old man is presented who had a 6 weeks history of cognitive deterioration and myoclonus. Brain magnetic resonance imaging (MRI) showed ribbon-like areas of hyperintensity in the bilateral cortex on diffusion-weighted imaging (DWI); bilateral hyperintense caudate nucleus and putamen on T2-weighted and Fluid-attenuated inversion recovery (FLAIR) images. Electroencephalogram (EEG) showed intermittent generalized periodic sharp waves of triphasic morphology. The diagnosis of probable sCJD was reached based on the clinical features and characteristic findings in his MRI and EEG according to WHO criteria. Several other works of the literature were also reviewed for early diagnosis of sCJD and for the exclusion of other differential diagnoses which may mimic sCJD.
| Published in | Clinical Neurology and Neuroscience (Volume 5, Issue 3) |
| DOI | 10.11648/j.cnn.20210503.16 |
| Page(s) | 63-67 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Creutzfeldt-Jakob Disease, Prion Disease, Myoclonus, Rapidly Progressing Dementia
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APA Style
Tareq Esteak, Mohammad Bazlur Rashid, Md. Ashrafuzzaman Khan, Mohammad Nur Uddin, Mashfiqul Hasan, et al. (2021). Sporadic Creutzfeldt - Jakob Disease: Case Report from a Neuroscience Institute in Bangladesh. Clinical Neurology and Neuroscience, 5(3), 63-67. https://doi.org/10.11648/j.cnn.20210503.16
ACS Style
Tareq Esteak; Mohammad Bazlur Rashid; Md. Ashrafuzzaman Khan; Mohammad Nur Uddin; Mashfiqul Hasan, et al. Sporadic Creutzfeldt - Jakob Disease: Case Report from a Neuroscience Institute in Bangladesh. Clin. Neurol. Neurosci. 2021, 5(3), 63-67. doi: 10.11648/j.cnn.20210503.16
AMA Style
Tareq Esteak, Mohammad Bazlur Rashid, Md. Ashrafuzzaman Khan, Mohammad Nur Uddin, Mashfiqul Hasan, et al. Sporadic Creutzfeldt - Jakob Disease: Case Report from a Neuroscience Institute in Bangladesh. Clin Neurol Neurosci. 2021;5(3):63-67. doi: 10.11648/j.cnn.20210503.16
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Download@article{10.11648/j.cnn.20210503.16,
author = {Tareq Esteak and Mohammad Bazlur Rashid and Md. Ashrafuzzaman Khan and Mohammad Nur Uddin and Mashfiqul Hasan and Paritosh Kumar Sarkar},
title = {Sporadic Creutzfeldt - Jakob Disease: Case Report from a Neuroscience Institute in Bangladesh},
journal = {Clinical Neurology and Neuroscience},
volume = {5},
number = {3},
pages = {63-67},
doi = {10.11648/j.cnn.20210503.16},
url = {https://doi.org/10.11648/j.cnn.20210503.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20210503.16},
abstract = {Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder characterized by rapidly progressive dementia and myoclonus. Additional clinical features include visual disturbances, cerebellar, and pyramidal/extrapyramidal signs. The rarity of this disease and the wide variety of initial symptoms make the early diagnosis quite challenging. Nevertheless, it can also be diagnosed in a centre with limited resources through good clinical analysis. Here a case of a 53-year-old man is presented who had a 6 weeks history of cognitive deterioration and myoclonus. Brain magnetic resonance imaging (MRI) showed ribbon-like areas of hyperintensity in the bilateral cortex on diffusion-weighted imaging (DWI); bilateral hyperintense caudate nucleus and putamen on T2-weighted and Fluid-attenuated inversion recovery (FLAIR) images. Electroencephalogram (EEG) showed intermittent generalized periodic sharp waves of triphasic morphology. The diagnosis of probable sCJD was reached based on the clinical features and characteristic findings in his MRI and EEG according to WHO criteria. Several other works of the literature were also reviewed for early diagnosis of sCJD and for the exclusion of other differential diagnoses which may mimic sCJD.},
year = {2021}
}
TY - JOUR T1 - Sporadic Creutzfeldt - Jakob Disease: Case Report from a Neuroscience Institute in Bangladesh AU - Tareq Esteak AU - Mohammad Bazlur Rashid AU - Md. Ashrafuzzaman Khan AU - Mohammad Nur Uddin AU - Mashfiqul Hasan AU - Paritosh Kumar Sarkar Y1 - 2021/09/26 PY - 2021 N1 - https://doi.org/10.11648/j.cnn.20210503.16 DO - 10.11648/j.cnn.20210503.16 T2 - Clinical Neurology and Neuroscience JF - Clinical Neurology and Neuroscience JO - Clinical Neurology and Neuroscience SP - 63 EP - 67 PB - Science Publishing Group SN - 2578-8930 UR - https://doi.org/10.11648/j.cnn.20210503.16 AB - Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder characterized by rapidly progressive dementia and myoclonus. Additional clinical features include visual disturbances, cerebellar, and pyramidal/extrapyramidal signs. The rarity of this disease and the wide variety of initial symptoms make the early diagnosis quite challenging. Nevertheless, it can also be diagnosed in a centre with limited resources through good clinical analysis. Here a case of a 53-year-old man is presented who had a 6 weeks history of cognitive deterioration and myoclonus. Brain magnetic resonance imaging (MRI) showed ribbon-like areas of hyperintensity in the bilateral cortex on diffusion-weighted imaging (DWI); bilateral hyperintense caudate nucleus and putamen on T2-weighted and Fluid-attenuated inversion recovery (FLAIR) images. Electroencephalogram (EEG) showed intermittent generalized periodic sharp waves of triphasic morphology. The diagnosis of probable sCJD was reached based on the clinical features and characteristic findings in his MRI and EEG according to WHO criteria. Several other works of the literature were also reviewed for early diagnosis of sCJD and for the exclusion of other differential diagnoses which may mimic sCJD. VL - 5 IS - 3 ER -
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