Natural products derived from plants play a vital part in preventing or treating various diseases or disorders in humans. Hyperlipidemia is one of the main pathological features of diseases affecting the circulatory system and diabetes mellitus. Presently available lipid-lowering drugs have been linked with some side effects. Herbal treatment for hyperlipidaemia has significantly fewer or no side effects and is reasonably inexpensive and locally accessible. Amaranthus spinosus belongs to the family Amaranthaceae is well known by many researchers for its various medicinal properties and is also known as "pigweed." The present study sought to assess the antihyperlipidaemic activity of the leaf extract by in vivo animal models. Here, acute hyperlipidemia was induced by intraperitoneal administration of dexamethasone (10 mgkg-1). The ethanol extract of A. spinosus leaf (EEASL) was administered daily at single doses of 250 and 500 mgkg-1, to dexamethasone-induced hyperlipidaemic rats for 8 days. The effect of EEASL on serum lipid profiles (total cholesterol, triglycerides low-density, very low-density, and high-density lipoprotein) were determined. EEASL was established to significantly decrease total serum cholesterol, triglycerides, low-density lipoprotein, Very low-density lipoprotein, and increased serum high-density lipoprotein compared to the hyperlipidaemic and vehicle only control models. The activities were also paralleled to the outcome exhibited by a standard antihyperlipidaemic agent, atorvastatin. The present investigation established pharmacological evidence to support the claim that EEASL contains active antihyperlipidaemic agents.
| Published in | Biochemistry and Molecular Biology (Volume 6, Issue 2) |
| DOI | 10.11648/j.bmb.20210602.12 |
| Page(s) | 25-34 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Antihyperlipidaemic, Amaranthus spinosus, in vivo, Lipid Profile, Atorvastatin, Dexamethasone
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APA Style
Raphael Dzinyela, Emmanuel Kwesi Asomaning, Abdul-Nasir Abdul-Baasit, Abdul Razak Alhassan, Ali Movahedi. (2021). An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats. Biochemistry and Molecular Biology, 6(2), 25-34. https://doi.org/10.11648/j.bmb.20210602.12
ACS Style
Raphael Dzinyela; Emmanuel Kwesi Asomaning; Abdul-Nasir Abdul-Baasit; Abdul Razak Alhassan; Ali Movahedi. An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats. Biochem. Mol. Biol. 2021, 6(2), 25-34. doi: 10.11648/j.bmb.20210602.12
AMA Style
Raphael Dzinyela, Emmanuel Kwesi Asomaning, Abdul-Nasir Abdul-Baasit, Abdul Razak Alhassan, Ali Movahedi. An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats. Biochem Mol Biol. 2021;6(2):25-34. doi: 10.11648/j.bmb.20210602.12
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Download@article{10.11648/j.bmb.20210602.12,
author = {Raphael Dzinyela and Emmanuel Kwesi Asomaning and Abdul-Nasir Abdul-Baasit and Abdul Razak Alhassan and Ali Movahedi},
title = {An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats},
journal = {Biochemistry and Molecular Biology},
volume = {6},
number = {2},
pages = {25-34},
doi = {10.11648/j.bmb.20210602.12},
url = {https://doi.org/10.11648/j.bmb.20210602.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20210602.12},
abstract = {Natural products derived from plants play a vital part in preventing or treating various diseases or disorders in humans. Hyperlipidemia is one of the main pathological features of diseases affecting the circulatory system and diabetes mellitus. Presently available lipid-lowering drugs have been linked with some side effects. Herbal treatment for hyperlipidaemia has significantly fewer or no side effects and is reasonably inexpensive and locally accessible. Amaranthus spinosus belongs to the family Amaranthaceae is well known by many researchers for its various medicinal properties and is also known as "pigweed." The present study sought to assess the antihyperlipidaemic activity of the leaf extract by in vivo animal models. Here, acute hyperlipidemia was induced by intraperitoneal administration of dexamethasone (10 mgkg-1). The ethanol extract of A. spinosus leaf (EEASL) was administered daily at single doses of 250 and 500 mgkg-1, to dexamethasone-induced hyperlipidaemic rats for 8 days. The effect of EEASL on serum lipid profiles (total cholesterol, triglycerides low-density, very low-density, and high-density lipoprotein) were determined. EEASL was established to significantly decrease total serum cholesterol, triglycerides, low-density lipoprotein, Very low-density lipoprotein, and increased serum high-density lipoprotein compared to the hyperlipidaemic and vehicle only control models. The activities were also paralleled to the outcome exhibited by a standard antihyperlipidaemic agent, atorvastatin. The present investigation established pharmacological evidence to support the claim that EEASL contains active antihyperlipidaemic agents.},
year = {2021}
}
TY - JOUR T1 - An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats AU - Raphael Dzinyela AU - Emmanuel Kwesi Asomaning AU - Abdul-Nasir Abdul-Baasit AU - Abdul Razak Alhassan AU - Ali Movahedi Y1 - 2021/06/30 PY - 2021 N1 - https://doi.org/10.11648/j.bmb.20210602.12 DO - 10.11648/j.bmb.20210602.12 T2 - Biochemistry and Molecular Biology JF - Biochemistry and Molecular Biology JO - Biochemistry and Molecular Biology SP - 25 EP - 34 PB - Science Publishing Group SN - 2575-5048 UR - https://doi.org/10.11648/j.bmb.20210602.12 AB - Natural products derived from plants play a vital part in preventing or treating various diseases or disorders in humans. Hyperlipidemia is one of the main pathological features of diseases affecting the circulatory system and diabetes mellitus. Presently available lipid-lowering drugs have been linked with some side effects. Herbal treatment for hyperlipidaemia has significantly fewer or no side effects and is reasonably inexpensive and locally accessible. Amaranthus spinosus belongs to the family Amaranthaceae is well known by many researchers for its various medicinal properties and is also known as "pigweed." The present study sought to assess the antihyperlipidaemic activity of the leaf extract by in vivo animal models. Here, acute hyperlipidemia was induced by intraperitoneal administration of dexamethasone (10 mgkg-1). The ethanol extract of A. spinosus leaf (EEASL) was administered daily at single doses of 250 and 500 mgkg-1, to dexamethasone-induced hyperlipidaemic rats for 8 days. The effect of EEASL on serum lipid profiles (total cholesterol, triglycerides low-density, very low-density, and high-density lipoprotein) were determined. EEASL was established to significantly decrease total serum cholesterol, triglycerides, low-density lipoprotein, Very low-density lipoprotein, and increased serum high-density lipoprotein compared to the hyperlipidaemic and vehicle only control models. The activities were also paralleled to the outcome exhibited by a standard antihyperlipidaemic agent, atorvastatin. The present investigation established pharmacological evidence to support the claim that EEASL contains active antihyperlipidaemic agents. VL - 6 IS - 2 ER -
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