Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI

Fu Xianzhao; Jiang Xiaofeng; Chen Jiajun; Cen Qianli; Li Yuegui; Qiu Haixian

doi:doi:10.11648/j.ajbls.20210905.20

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Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI

Fu Xianzhao, Jiang Xiaofeng, Chen Jiajun, Cen Qianli, Li Yuegui, Qiu Haixian

Published in American Journal of Biomedical and Life Sciences (Volume 9, Issue 5)

Received: 2 October 2021 Accepted: 26 October 2021 Published: 5 November 2021

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Abstract

Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were equally randomized into the treatment group (46) and the control group (46) from January 2016 to August 2016. The control group were given standardized western medicine, while treatment group received HJJR besides standardized treatment. The treating course were 2 months. Before and after treatment, the left ventricular morphology index [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic ventricular septal thickness (LVEST)] and the cardiac function data [stroke volume (SV), left ventricular fractional shortening (FS), the cardiac index (CI), cardiac output (CO), maximum blood flow velocity of early diastolic/ atrium late diastolic (E/A), left ventricle ejection fraction (EF)] were detected with echocardiography. The serum levels of C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and Angiotensin II (Ang II) were tested with enzyme linked immunosorbent assay (ELISA), and the clinical efficacy and 5-year survival rate were evaluated. Results The total clinical effective rate and 5-year survival ratio in treatment group were higher than those in control group (P<0.05). Serum inflammatory mediators (CRP, IL-6, TNF-α) and Ang II decreased more than that in the control group (all P<0.05); And in treatment group, the left ventricular morphology index (LVESD, LVEDD) decreased more than that in the control group, while the cardiac function indexes (∆ FS, CO, CI, SV, LVEF, E/A) were increased more in treatment group. Conclusion HJJR can hold back the deterioration of heart restructure, improve heart function, ameliorate prognosis and prolong living in diabetic CHD after PCI, and its partial therapeutic effects might come from its reducing the level of Ang II and anti-inflammatory function.

Published in	American Journal of Biomedical and Life Sciences (Volume 9, Issue 5)
DOI	10.11648/j.ajbls.20210905.20
Page(s)	286-291
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Huoxue Jiedu Jiangtang Recipe, Diabetes Mellitus, Coronary Heart Disease, Heart Remodeling, Percutaneous Coronary Intervention

References

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APA Style

Fu Xianzhao, Jiang Xiaofeng, Chen Jiajun, Cen Qianli, Li Yuegui, et al. (2021). Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI. American Journal of Biomedical and Life Sciences, 9(5), 286-291. https://doi.org/10.11648/j.ajbls.20210905.20

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ACS Style

Fu Xianzhao; Jiang Xiaofeng; Chen Jiajun; Cen Qianli; Li Yuegui, et al. Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI. Am. J. Biomed. Life Sci. 2021, 9(5), 286-291. doi: 10.11648/j.ajbls.20210905.20

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AMA Style

Fu Xianzhao, Jiang Xiaofeng, Chen Jiajun, Cen Qianli, Li Yuegui, et al. Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI. Am J Biomed Life Sci. 2021;9(5):286-291. doi: 10.11648/j.ajbls.20210905.20

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@article{10.11648/j.ajbls.20210905.20,
  author = {Fu Xianzhao and Jiang Xiaofeng and Chen Jiajun and Cen Qianli and Li Yuegui and Qiu Haixian},
  title = {Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {9},
  number = {5},
  pages = {286-291},
  doi = {10.11648/j.ajbls.20210905.20},
  url = {https://doi.org/10.11648/j.ajbls.20210905.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210905.20},
  abstract = {Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were equally randomized into the treatment group (46) and the control group (46) from January 2016 to August 2016. The control group were given standardized western medicine, while treatment group received HJJR besides standardized treatment. The treating course were 2 months. Before and after treatment, the left ventricular morphology index [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic ventricular septal thickness (LVEST)] and the cardiac function data [stroke volume (SV), left ventricular fractional shortening (FS), the cardiac index (CI), cardiac output (CO), maximum blood flow velocity of early diastolic/ atrium late diastolic (E/A), left ventricle ejection fraction (EF)] were detected with echocardiography. The serum levels of C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and Angiotensin II (Ang II) were tested with enzyme linked immunosorbent assay (ELISA), and the clinical efficacy and 5-year survival rate were evaluated. Results The total clinical effective rate and 5-year survival ratio in treatment group were higher than those in control group (PConclusion HJJR can hold back the deterioration of heart restructure, improve heart function, ameliorate prognosis and prolong living in diabetic CHD after PCI, and its partial therapeutic effects might come from its reducing the level of Ang II and anti-inflammatory function.},
 year = {2021}
}

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TY  - JOUR
T1  - Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI
AU  - Fu Xianzhao
AU  - Jiang Xiaofeng
AU  - Chen Jiajun
AU  - Cen Qianli
AU  - Li Yuegui
AU  - Qiu Haixian
Y1  - 2021/11/05
PY  - 2021
N1  - https://doi.org/10.11648/j.ajbls.20210905.20
DO  - 10.11648/j.ajbls.20210905.20
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 286
EP  - 291
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20210905.20
AB  - Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were equally randomized into the treatment group (46) and the control group (46) from January 2016 to August 2016. The control group were given standardized western medicine, while treatment group received HJJR besides standardized treatment. The treating course were 2 months. Before and after treatment, the left ventricular morphology index [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic ventricular septal thickness (LVEST)] and the cardiac function data [stroke volume (SV), left ventricular fractional shortening (FS), the cardiac index (CI), cardiac output (CO), maximum blood flow velocity of early diastolic/ atrium late diastolic (E/A), left ventricle ejection fraction (EF)] were detected with echocardiography. The serum levels of C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and Angiotensin II (Ang II) were tested with enzyme linked immunosorbent assay (ELISA), and the clinical efficacy and 5-year survival rate were evaluated. Results The total clinical effective rate and 5-year survival ratio in treatment group were higher than those in control group (PConclusion HJJR can hold back the deterioration of heart restructure, improve heart function, ameliorate prognosis and prolong living in diabetic CHD after PCI, and its partial therapeutic effects might come from its reducing the level of Ang II and anti-inflammatory function.
VL  - 9
IS  - 5
ER  -

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Author Information

Fu Xianzhao

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Jiang Xiaofeng

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Chen Jiajun

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Cen Qianli

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Li Yuegui

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China
Qiu Haixian

The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China

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Plain Text BibTeX RIS

APA Style

Fu Xianzhao, Jiang Xiaofeng, Chen Jiajun, Cen Qianli, Li Yuegui, et al. (2021). Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI. American Journal of Biomedical and Life Sciences, 9(5), 286-291. https://doi.org/10.11648/j.ajbls.20210905.20

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ACS Style

Fu Xianzhao; Jiang Xiaofeng; Chen Jiajun; Cen Qianli; Li Yuegui, et al. Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI. Am. J. Biomed. Life Sci. 2021, 9(5), 286-291. doi: 10.11648/j.ajbls.20210905.20

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AMA Style

Fu Xianzhao, Jiang Xiaofeng, Chen Jiajun, Cen Qianli, Li Yuegui, et al. Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI. Am J Biomed Life Sci. 2021;9(5):286-291. doi: 10.11648/j.ajbls.20210905.20

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@article{10.11648/j.ajbls.20210905.20,
  author = {Fu Xianzhao and Jiang Xiaofeng and Chen Jiajun and Cen Qianli and Li Yuegui and Qiu Haixian},
  title = {Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {9},
  number = {5},
  pages = {286-291},
  doi = {10.11648/j.ajbls.20210905.20},
  url = {https://doi.org/10.11648/j.ajbls.20210905.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210905.20},
  abstract = {Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were equally randomized into the treatment group (46) and the control group (46) from January 2016 to August 2016. The control group were given standardized western medicine, while treatment group received HJJR besides standardized treatment. The treating course were 2 months. Before and after treatment, the left ventricular morphology index [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic ventricular septal thickness (LVEST)] and the cardiac function data [stroke volume (SV), left ventricular fractional shortening (FS), the cardiac index (CI), cardiac output (CO), maximum blood flow velocity of early diastolic/ atrium late diastolic (E/A), left ventricle ejection fraction (EF)] were detected with echocardiography. The serum levels of C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and Angiotensin II (Ang II) were tested with enzyme linked immunosorbent assay (ELISA), and the clinical efficacy and 5-year survival rate were evaluated. Results The total clinical effective rate and 5-year survival ratio in treatment group were higher than those in control group (PConclusion HJJR can hold back the deterioration of heart restructure, improve heart function, ameliorate prognosis and prolong living in diabetic CHD after PCI, and its partial therapeutic effects might come from its reducing the level of Ang II and anti-inflammatory function.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Double Regulation of Tonifying-Detoxifing on Elderly Diabetic Coronary Heart Disease After PCI
AU  - Fu Xianzhao
AU  - Jiang Xiaofeng
AU  - Chen Jiajun
AU  - Cen Qianli
AU  - Li Yuegui
AU  - Qiu Haixian
Y1  - 2021/11/05
PY  - 2021
N1  - https://doi.org/10.11648/j.ajbls.20210905.20
DO  - 10.11648/j.ajbls.20210905.20
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 286
EP  - 291
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20210905.20
AB  - Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were equally randomized into the treatment group (46) and the control group (46) from January 2016 to August 2016. The control group were given standardized western medicine, while treatment group received HJJR besides standardized treatment. The treating course were 2 months. Before and after treatment, the left ventricular morphology index [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic ventricular septal thickness (LVEST)] and the cardiac function data [stroke volume (SV), left ventricular fractional shortening (FS), the cardiac index (CI), cardiac output (CO), maximum blood flow velocity of early diastolic/ atrium late diastolic (E/A), left ventricle ejection fraction (EF)] were detected with echocardiography. The serum levels of C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and Angiotensin II (Ang II) were tested with enzyme linked immunosorbent assay (ELISA), and the clinical efficacy and 5-year survival rate were evaluated. Results The total clinical effective rate and 5-year survival ratio in treatment group were higher than those in control group (PConclusion HJJR can hold back the deterioration of heart restructure, improve heart function, ameliorate prognosis and prolong living in diabetic CHD after PCI, and its partial therapeutic effects might come from its reducing the level of Ang II and anti-inflammatory function.
VL  - 9
IS  - 5
ER  -

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