This research work investigated the anti-diabetic, anti-hyperlipidemic, and anti-oxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin-induced diabetic Wistar rats. Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8rats each. Group1served as the control; Group2-5were induced with diabetes with a single dose of 50mg/kgbw of streptozotocin intraperitoneally. After diabetes induction, Group2 served as the streptozotocin only group, Group3and4 were administered 100mg/kgbw and 200mg/kgbwp.o of Anacardium occidentale nut extract, respectively, while Group5 was administered 2mg/kgbw of glimepiride as a reference drug for a period of 4weeks. Food and water intake were monitored daily, bodyweight, and blood glucose levels weekly throughout the experiment. On day29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Administration of Anacardium occidentale nut extract significantly decreased (p<0.05) the fasting blood glucose level, oral glucose tolerance test (OGTT), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) concentrations and significantly increase (p<0.05) the high-density lipoprotein (HDL) in diabetic treated rats. Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Reduced glutathione (GSH), and Catalase (CAT) levels significantly (p<0.05) increases with a decrease Malondialdehyde (MDA) level in diabetic treated rats. Food intake and bodyweight of diabetic treated rats significantly increases (p<0.05). Markers of liver and kidney functions were also improved in diabetic treated rats. The results from this study suggest that Anacardium occidentale nut may be useful in the therapeutic management of diabetes and its related complications.
| Published in | American Journal of Biomedical and Life Sciences (Volume 9, Issue 3) |
| DOI | 10.11648/j.ajbls.20210903.11 |
| Page(s) | 133-141 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Anacardium occidentale, Diabetes, Dyslipidemia, Oxidative Stress, Liver
| [1] | Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, and Malanda B (2018). “IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045,” Diabetes Research and Clinical Practice, 2018. |
| [2] | International Diabetes Federation (2011). IDF Diabetes Atlas 5th Ed. Pp 45 https://www.idf.org/e-library/epidemiology-research/diabetes-atlas/20-atlas-5th-edition.html. |
| [3] | Cavan D, da Rocha Fernandes J, Makaroff L, Ogurtsova K, and Webber S. (2015). IDF Diabetes Atlas, International Diabetes Federation, Brussels, Belgium, 7th edition. |
| [4] | Kesavadev J, Saboo B, Sadikot S, Das AK, Joshi S, Chawla R, Thacker H, Shankar A, Ramachandra L, and Kalra S (2017). Unproven therapies for diabetes and their implications. Adv Ther; 34 (1): 60–77. |
| [5] | Hu XF, Zhang Q, Zhang PP, Sun LJ, Liang JC, Morris-Natschke SL, Chen Y, and Lee KH (2018). Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi. Fitoterapia, 127, 129–137. [CrossRef] |
| [6] | Lipinski B. (2001). Pathophysiology of oxidative stress in diabetes mellitus. J. Diabetes its Complications 15 (4): 203–210. DOI: 10.1016/s1056-8727(01)00143-x. |
| [7] | Pham-Huy LA, He H, and Pham-Huy C (2008). Free radicals, antioxidant in disease and health. IJBS 4 (2): 89–96. PMC3614697. |
| [8] | Giugliano D, Ceriello A, and Paolisso G, (1996). Oxidative stress and diabetic vascular complications. Diabetes Care19: 257-267. DOI: 10.2337/diacare.19.3.257. |
| [9] | Quiles JC, Mesa MD, Ramirez-Tortosa CL, Auiglera CM, Battino M, Gil A, and Ramirez-Tortosa MC (2002). Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler Tromb Vasc Biol. 22: 1225 DOI: 10.1161/01.atv.0000020676.11586.f2. |
| [10] | Marín-Peñalver JJ, Martín-Timón I, Sevillano-Collantes C, and del Cañizo-Gómez, FJ (2016). Update on the treatment of type 2 diabetes mellitus. World J. Diabetes, 7, 354–395. |
| [11] | Paris R, Plat M, Giono-Barder P, Linhard J, and Laurens A (1977). Recherchechimique etpharmacologiquesur les feuillesd’Anacardiumoccidentale. Bull la SociétédeMédecine d'Afrique Noire Lang Française. 22: 275–281. http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=PASCAL7850211646. |
| [12] | Souza MQ, Teotônio IMSN, deAlmeida FC, Heyn GS, Alves PS, Romeiro LAS, and Pratesi, CB (2018). Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL). BMC Complementary and Alternative Medicine, 18 (1), 1-11. doi: 10.1186/s12906-018-2247-0. |
| [13] | Adriano-Anaya L, Trejo-Roblero G, Rosas-Quijano R, Velázquez-Ovalle G, and Vázquez-Ovando A (2017). Mejoramiento del rendimiento y calidad del fruto y pseudofruto de marañonL. con un ciclo de fertilización orgánica. Revista Brasileira de Fruticultura, 39 (5), 674. doi: 10.1590/0100-29452017674. |
| [14] | Montanari RM, Barbosa LCA, Demuner A. J, Silva CJ, Andrade NJ, Ismail FMD, and Barbosa MCA (2012). Exposure to anacardiaceae volatile oils and their constituents induces lipid peroxidation within food-borne bacteria cells. Molecules, 17 (8), 9728-9740. doi: 10.3390/molecules17089728. |
| [15] | Silva MIG, Melo CTVDe, Vasconcelos LF, Carvalho AMRDe, and Sousa FCF (2012). Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature. Revista Brasileirade Farmacognosia, 22 (1), 193-207. doi: 10.1590/S0102-695X2011005000171. |
| [16] | Mustapha AA, Owuna G, Ogaji JO, Is-haq UI, and Idris MM (2015). Phytochemical screening and inhibitory activities of Anacardium occidentale leaf extracts against some clinically important bacterial isolates. International Journal of Pharmacognosy and Phytochemical Research. 7 (2): 365-369. |
| [17] | Fazali F, Zulkhairi A, Nurhaizan ME, Kamal NH, Zamree MS, and Shahidan MA (2011). Phytochemical Screening, invitro and invivo Antioxidant Activities of Aqueous Extract of Anacardium occidentale Linn. And its Effects on Endogenous Antioxidant Enzymes in Hypercholesterolemic Induced Rabbits. Res. J. Biol. Sci. 6 (2): 69-74. |
| [18] | Ojewole JA (2003): Laboratory evaluation of the hypoglycemic effect of Anacardium occidentale Linn (Anacardiaceae) stem-bark extracts in rats. Methods Find Exp Clin Pharmacol 25: 199–204. |
| [19] | Felcman J, and Braganca ML (1987). Chromium in plants: comparison between the concentration of chromium in Brasilian non hypo and hypoglycemic plants. Biol Trace Elem Res.; 17: 11–16 https://doi.org/10.1007/BF02795443. |
| [20] | Gupta M, Arias T, Correa M and Lamba S (1979). Ethnopharmacognostic observations on Panamanian medicinal plants. JCrudeDrugRes 17: 115–130. https://doi.org/10.3109/13880207909065163. |
| [21] | Committee for the Update of the Guide for the Care and Use of Laboratory Animals Institute for Laboratory Animal Research Division on Earth and Life Studies. Guide for the Care and Use of Laboratory Animals. In: National Research Council of the National Academies. 8th ed. Washington DC: The National Academies Press; 2011. |
| [22] | Harwood L, Moody M, and Christopher J (1989). Experimental organic chemistry: Principles and Practice. Wiley-Blackwell., pp 122-125. https://www.wiley.com/en-us/ Experimental + Organic + Chemistry%2C+3rd+Edition-p-9781119952381. |
| [23] | Sofowora, A. (1993). Medicinal Plants and Traditional Medicinal in Africa. Screening Plants for Bioactive Agents, 2nd Edn, Ibadan: Spectrum books limited. doi: 10.1016/S0378-8741(99)00136-1. |
| [24] | Trease GE, and Evans WC (2002). Pharmacognosy, 15thEdn, London: Saunders Publishers. |
| [25] | Lorke D (1983). A new approach to practical acute toxicity testing. ArchToxicol. 1983; 54: 275–8710.1007/BF01234480. |
| [26] | Gupta R, and Gupta RS (2009). Protective Role of Pterocarpus marsupium in Diabetes-Induced Hyperlipidemic Condition. Journal of Complementary and Integrative Medicine 6 (1): 21 DOI: https://doi.org/10.2202. |
| [27] | Trinder P (1969). Determination of Blood Glucose Using an Oxidase-Peroxidase System With a Non-Carcinogenic Chromogen. J Clin Pathol 22 (2): 158-61. doi: 10.1136/jcp.22.2.158. |
| [28] | Burtis C, and Ashood E (1999). Textbook of clinical chemistry. 3thed. London. Vol. 2 Chapter 33: 1145–1150.10.1007/s12291-012-0287-7. |
| [29] | American Diabetes Association (2014). Standards of Medical Care in Diabetes. Diabetes Care 37 (1): S14–S80 https://doi.org/10.2337/dc14-S014. |
| [30] | Hunt JV, Dean RT and Wolff SP (1988). “Hydroxyl radical production and antioxidative glycosylation”. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and aging. Biochemical journal. 256 (1): 205-212 doi: 10.1042/bj2560205. |
| [31] | Minnich A, and Zilversmit DB (1989). Impaired triacylglycerol catabolism in hypertriglyceremia of the diabetic, cholesterol fed rabbit: A possible mechanism for protection from atherosclerosis. Biochem. Biophys. Acta. 1002: 324-332 https://doi.org/10.1016/0005-2760(89)90346-9. |
| [32] | Akah PA, and Okafor CL (1992). Blood sugar lowering effect of Vernonia amygdalina Del, in an experimental rabbit model. Phytotherapy research 6 (3): 117-173, 1992 https://doi.org/10.1002/ptr.2650060318. |
| [33] | Swanston-Flatt SK, Day C, Flatt PR, Gould BJ, and Bailey CJ. (1989). Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetes Res. 10 (2): 69-73. PMID: 2743711. |
| [34] | Tang H, Li D, Li Y, Zhang X, Song Y, and Li X (2018). Effects of Vitamin D Supplementation on Glucose and Insulin Homeostasis and Incident Diabetes among Non diabetic Adults: A Meta-Analysis of Randomized Controlled Trials. Int J Endocrinol (1): 19 https://doi.org/10.1155/2018/7908764. |
| [35] | Tuteja S, and Rader DJ (2014). High-density lipoproteins in the prevention of cardiovascular disease: changing the paradigm. Clin Pharmacol Ther, 96 (1): 4856 DOI: 10.1038/clpt.2014.79. |
| [36] | AlAwwadi NA, Bornet A, Azay J, Araiz C, Delbosc S, Cristol JP, and Teissedre PL (2004). Red wine polyphenols alone or in association with ethanol prevent hypertension, cardiac hypertrophy, and production of reactive oxygen species in the insulin-resistant fructose-fedrat. Journal of Agricultural and Food Chemistry, 52 (18), 5593–5597 10.1021/jf049295g. |
| [37] | Snigur GL, Samokhina MP, Pisarev VB, Spasov AA and Bulanov AE (2008). Structural alterations in pancreatic islets in streptozotocin-induced diabetic rats treated with bioactive additive on the basis of Gymnema sylvestre. Morfologiia, 133 (1): 60-4. https://europepmc.org/article/med/19069418. |
| [38] | Inove M, Satio Y, Hirato E, Morino Y, and Nagase S. (1987). Regulation of redox status of plasma proteins by mechanism and transport of glutathione and related compounds. J Protein Chem; 36: 169. |
APA Style
Folasade Omobolanle Ajao, Michael Adeyemi Olamoyegun, Marcus Olaoye Iyedupe. (2021). The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats. American Journal of Biomedical and Life Sciences, 9(3), 133-141. https://doi.org/10.11648/j.ajbls.20210903.11
ACS Style
Folasade Omobolanle Ajao; Michael Adeyemi Olamoyegun; Marcus Olaoye Iyedupe. The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats. Am. J. Biomed. Life Sci. 2021, 9(3), 133-141. doi: 10.11648/j.ajbls.20210903.11
AMA Style
Folasade Omobolanle Ajao, Michael Adeyemi Olamoyegun, Marcus Olaoye Iyedupe. The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats. Am J Biomed Life Sci. 2021;9(3):133-141. doi: 10.11648/j.ajbls.20210903.11
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Download@article{10.11648/j.ajbls.20210903.11,
author = {Folasade Omobolanle Ajao and Michael Adeyemi Olamoyegun and Marcus Olaoye Iyedupe},
title = {The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats},
journal = {American Journal of Biomedical and Life Sciences},
volume = {9},
number = {3},
pages = {133-141},
doi = {10.11648/j.ajbls.20210903.11},
url = {https://doi.org/10.11648/j.ajbls.20210903.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210903.11},
abstract = {This research work investigated the anti-diabetic, anti-hyperlipidemic, and anti-oxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin-induced diabetic Wistar rats. Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8rats each. Group1served as the control; Group2-5were induced with diabetes with a single dose of 50mg/kgbw of streptozotocin intraperitoneally. After diabetes induction, Group2 served as the streptozotocin only group, Group3and4 were administered 100mg/kgbw and 200mg/kgbwp.o of Anacardium occidentale nut extract, respectively, while Group5 was administered 2mg/kgbw of glimepiride as a reference drug for a period of 4weeks. Food and water intake were monitored daily, bodyweight, and blood glucose levels weekly throughout the experiment. On day29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Administration of Anacardium occidentale nut extract significantly decreased (pAnacardium occidentale nut may be useful in the therapeutic management of diabetes and its related complications.},
year = {2021}
}
TY - JOUR T1 - The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats AU - Folasade Omobolanle Ajao AU - Michael Adeyemi Olamoyegun AU - Marcus Olaoye Iyedupe Y1 - 2021/05/08 PY - 2021 N1 - https://doi.org/10.11648/j.ajbls.20210903.11 DO - 10.11648/j.ajbls.20210903.11 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 133 EP - 141 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20210903.11 AB - This research work investigated the anti-diabetic, anti-hyperlipidemic, and anti-oxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin-induced diabetic Wistar rats. Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8rats each. Group1served as the control; Group2-5were induced with diabetes with a single dose of 50mg/kgbw of streptozotocin intraperitoneally. After diabetes induction, Group2 served as the streptozotocin only group, Group3and4 were administered 100mg/kgbw and 200mg/kgbwp.o of Anacardium occidentale nut extract, respectively, while Group5 was administered 2mg/kgbw of glimepiride as a reference drug for a period of 4weeks. Food and water intake were monitored daily, bodyweight, and blood glucose levels weekly throughout the experiment. On day29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Administration of Anacardium occidentale nut extract significantly decreased (pAnacardium occidentale nut may be useful in the therapeutic management of diabetes and its related complications. VL - 9 IS - 3 ER -
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