American Journal of Internal Medicine

Special Issue

New Approaches to Manage Difficult-to-Control, Severe Asthma

  • Submission Deadline: Feb. 15, 2020
  • Status: Submission Closed
  • Lead Guest Editor: Yurii Feshchenko
About This Special Issue
Asthma is chronic heterogeneous disease, affecting 1-18 % of the population. According WHO Global Burden of Disease Study, 13, 8 million disability-adjusted life-years (DALYs) are lost annually due to asthma, representing 1, 8 % of the total global disease burden. The main economic and social burden falls on difficult-to-control, severe asthma - due to the medications, physician visits, hospitalizations, and cost of OCS side effects.
Difficult-to-control, severe asthma also placed a large physical, mental, emotional burden. Difficult-to-control asthma – multi-factor problem, and investigation of background reasons, biological, patient-dependent or social, connected with government policy, health care system is of high priority.
Comorbidities, modifiable risk factors, incorrect technique of inhalation, suboptimal adherence , deficiencies in continuity between GPs and specialists (not timely referral to a specialist in severe, atypical cases) aggravates it’s course of the disease and makes difficult to achieve good asthma control.
Active interest and research continues - in study of inflammation (special atypical inflammation in late adult onset), particularities of pulmonary function and it’s changes over time, localization of injury in airways in difficult-to-control, severe asthma patients, unsatisfactory response to full-fledged standard therapy.
Allergy, rhinitis, professional asthma, neurological, psychological problems (anxiety and depression), breathing disturbances during sleep – are in sphere of interest of modern asthma management and necessitates attraction of multidisciplinary team with participation of pulmonologists, allergologists, otolaryngologists and other specialists in indicated cases.
Established timely cooperation between GPs and specialists, personalized approach to therapy, allocation of risk factors for disability, death, prediction of adverse outcomes will improve effectiveness of asthma treatment with the fewer side effects.
We hope and expect that the insight the special issue will bring present scientific need, stimulate further research interest and create a platform for future scientific research and will be of interest and useful for GPs and specialists.

Aims and Scope:

  1. Difficult-to-control, severe asthma
  2. Cooperation between GPs and specialists
  3. Inflammation
  4. Pulmonary function
  5. Comorbidities
  6. Asthma management
Lead Guest Editor
  • Yurii Feshchenko

    Department of Pulmonology,State Organization “National Institute of Phthisiology and Pulmonology named after F.G. Yanovskiy, National Academy of Medical Science of Ukraine”, Shupic National Medical Academy of Postgraduate Education, Kyiv, Ukraine

Guest Editors
  • Anzhela Basanets

    Clinic for Occupational Diseases, Institute for Occupational Health, Kyiv, Ukraine

  • Olena Rechkina

    Department of Pediatric Pulmonology and Allergology,State Organization “National Institute of Phthisiology and Pulmonology named after F.G. Yanovskiy, National Academy of Medical Science of Ukraine”, Kyiv, Ukraine

  • Tetyana Pertseva

    State Institution “Dnipropetrovsk Medical Academy Ministry of Health of Ukraine”, Dnipro, Ukraine

  • Yuriy Mostovoi

    Department of propaedeutics in the internal medicine,Vinnitsa National Memorial Medical University named after M.I. Pyrogov Ministry of Health of Ukraine, Vinnitsa, Ukraine

  • Mycola Ostrovskyy

    State Higher Educational institution "Ivano-Frankivsk National Medical University", Ivano-Frankivsk, Ukraine

  • Liudmyla Iashyna

    Department of Diagnostic, Therapy and Clinical Pharmacology of Lung Diseases,State Organization “National Institute of Phthisiology and Pulmonology named after F.G. Yanovskiy, National Academy of Medical Science of Ukraine”, Kyiv, Ukraine

Published Articles
  • Models of Gen-gene Interaction in Determining the Severity of Bronchial Asthma in Children

    Оlena Rechkina , Nataliia Gorovenko , Vira Stryzh , Zoia Rossokha , Svitlana Kyriachenko , Serhii Rudenko

    Issue: Volume 8, Issue 4, July 2020
    Pages: 182-191
    Received: Feb. 14, 2020
    Accepted: Apr. 22, 2020
    Published: Aug. 04, 2020
    DOI: 10.11648/j.ajim.20200804.17
    Abstract: Bronchial asthma (BA) has a polygenic nature, and the onset of its manifestation and features course is realized due to the influence of genetic factors. This study aimed to investigate the effect of polymorphisms of the genes of the phase II detoxification system and genes of the cardiovascular tone on the severity of asthma in children. The study... Show More
  • Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment

    Tetyana Konstantynovych , Anna Demchuk , Alina Dovgan , Yuriy Mostovoy

    Issue: Volume 8, Issue 2, March 2020
    Pages: 66-72
    Received: Feb. 07, 2020
    Accepted: Feb. 27, 2020
    Published: Mar. 10, 2020
    DOI: 10.11648/j.ajim.20200802.14
    Abstract: The investigation is devoted to the problem of improvement of diagnostics and treatment of the somatopsychic phenotype (SPPh) at patients with bronchial asthma (BA). On the basis of complex clinical, instrumental, psychological inspection, investigation of the parameters of life quality by MOS SF-36 questionnaire of 207 BA-patients certain prevalen... Show More
  • Modern View on the Problem of Bronchial Asthma Comorbidity

    Mykola Ostrovskyy , Lilia Todoriko , Oleksandr Varunkiv , Iryna Makoida , Halyna Korzh , Mariana Kulynych-Miskiv , Liudmyla Babliuk , Olha Molodovets

    Issue: Volume 8, Issue 2, March 2020
    Pages: 51-56
    Received: Dec. 24, 2019
    Accepted: Feb. 04, 2020
    Published: Mar. 02, 2020
    DOI: 10.11648/j.ajim.20200802.11
    Abstract: We have examined 40 patients with bronchial asthma (BA) based at the municipal non-profit enterprise "Ivano-Frankivsk Regional Phthisiopulmonology Center of the Ivano-Frankivsk Regional Council" (Center for Pulmonary Diseases). The patients were randomized into two groups: Group I (17) involved patients with BA, Group II included (23) patients suff... Show More
  • Management of the Bronchial Asthma Patients at Practice of Family Doctors

    Yuriy Mostovoy , Anna Demchuk , Tetyana Konstantynovych

    Issue: Volume 8, Issue 1, January 2020
    Pages: 45-50
    Received: Feb. 09, 2020
    Accepted: Feb. 18, 2020
    Published: Feb. 28, 2020
    DOI: 10.11648/j.ajim.20200801.19
    Abstract: With purpose to assess the primary care for bronchial asthma (BA) patients the anonymous survey of 175 family doctors was performed. We established low percent (2,9%) of self-depended diagnosis of BA by family doctors. It showed their extremely poor role in the primary BA diagnosis. The most frequently diagnosis of BA made by pulmonologist or aller... Show More
  • Capnometry in the Assessment of Pulmonary Ventilation in Patients with Bronchial Asthma

    Yurii Feshchenko , Liudmyla Iashyna , Svitlana Opimakh , Maryna Polianska , Viktoria Ignatieva , Svitlana Moskalenko , Galyna Gumenuk , Inna Zvol , Nataliia Vlasova , Liudmyla Halai

    Issue: Volume 8, Issue 1, January 2020
    Pages: 14-18
    Received: Dec. 16, 2019
    Accepted: Jan. 03, 2020
    Published: Jan. 13, 2020
    DOI: 10.11648/j.ajim.20200801.13
    Abstract: Background: Bronchial obstruction as characteristic feature of bronchial asthma (BA) can lead to gas exchange disorders. The distinction of asthma is that even in patients without clinical symptoms and almost normal spirometry parameters may have been significant gas exchange disorders including that due alveolar ventilation reducing. This study ai... Show More