The current study was performed on 178 paraffin embedded tissue specimens, included 111 of them were affected by thyroid carcinoma, 46 were benign neoplastic and 21individuals as control group. The study was carried out in Laboratory of College of Science, University of Wasit in collaboration with AL-Hussein Teaching Hospital and Ibn al-Bitar Laboratory Specialist in Thi Qar Province, IRAQ, from October 2015 to April 2016. Immunohistochemical technique was used to determination the expression of TGFα and its receptor EGFR in thyroid carcinoma in comparison with benign thyroid disease and control group. The aim of this study is to detect, quantify and analyze the clinicopathological correlation of those genes in patients with thyroid carcinoma. The results showed a significant increase of TGFα in thyroid patients comparing with control group and benign neoplasms, and between control group and benign neoplasms (p<0.05). On the other hand, the positive expression of EGFR was increased but did not reach to significantly difference in thyroid carcinoma in comparison with neither benign neoplasms nor control group (p>0.05). Our results concluded that there is a strong relationship between TGFα overexpression with thyroid carcinogenesis.
| Published in | American Journal of Health Research (Volume 5, Issue 2) |
| DOI | 10.11648/j.ajhr.20170502.14 |
| Page(s) | 44-49 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Thyroid Cancer, TGFα, EGFR and Immunohistochemistry
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APA Style
Tahani Abduljabbar Nasser, Kareem Hamed Ghali, Hameed Naeem Mousa. (2017). Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma. American Journal of Health Research, 5(2), 44-49. https://doi.org/10.11648/j.ajhr.20170502.14
ACS Style
Tahani Abduljabbar Nasser; Kareem Hamed Ghali; Hameed Naeem Mousa. Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma. Am. J. Health Res. 2017, 5(2), 44-49. doi: 10.11648/j.ajhr.20170502.14
AMA Style
Tahani Abduljabbar Nasser, Kareem Hamed Ghali, Hameed Naeem Mousa. Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma. Am J Health Res. 2017;5(2):44-49. doi: 10.11648/j.ajhr.20170502.14
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Download@article{10.11648/j.ajhr.20170502.14,
author = {Tahani Abduljabbar Nasser and Kareem Hamed Ghali and Hameed Naeem Mousa},
title = {Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma},
journal = {American Journal of Health Research},
volume = {5},
number = {2},
pages = {44-49},
doi = {10.11648/j.ajhr.20170502.14},
url = {https://doi.org/10.11648/j.ajhr.20170502.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20170502.14},
abstract = {The current study was performed on 178 paraffin embedded tissue specimens, included 111 of them were affected by thyroid carcinoma, 46 were benign neoplastic and 21individuals as control group. The study was carried out in Laboratory of College of Science, University of Wasit in collaboration with AL-Hussein Teaching Hospital and Ibn al-Bitar Laboratory Specialist in Thi Qar Province, IRAQ, from October 2015 to April 2016. Immunohistochemical technique was used to determination the expression of TGFα and its receptor EGFR in thyroid carcinoma in comparison with benign thyroid disease and control group. The aim of this study is to detect, quantify and analyze the clinicopathological correlation of those genes in patients with thyroid carcinoma. The results showed a significant increase of TGFα in thyroid patients comparing with control group and benign neoplasms, and between control group and benign neoplasms (p0.05). Our results concluded that there is a strong relationship between TGFα overexpression with thyroid carcinogenesis.},
year = {2017}
}
TY - JOUR T1 - Expression of Transforming Growth Factorα and Epidermal Growth Factor Receptor in Thyroid Carcinoma AU - Tahani Abduljabbar Nasser AU - Kareem Hamed Ghali AU - Hameed Naeem Mousa Y1 - 2017/03/09 PY - 2017 N1 - https://doi.org/10.11648/j.ajhr.20170502.14 DO - 10.11648/j.ajhr.20170502.14 T2 - American Journal of Health Research JF - American Journal of Health Research JO - American Journal of Health Research SP - 44 EP - 49 PB - Science Publishing Group SN - 2330-8796 UR - https://doi.org/10.11648/j.ajhr.20170502.14 AB - The current study was performed on 178 paraffin embedded tissue specimens, included 111 of them were affected by thyroid carcinoma, 46 were benign neoplastic and 21individuals as control group. The study was carried out in Laboratory of College of Science, University of Wasit in collaboration with AL-Hussein Teaching Hospital and Ibn al-Bitar Laboratory Specialist in Thi Qar Province, IRAQ, from October 2015 to April 2016. Immunohistochemical technique was used to determination the expression of TGFα and its receptor EGFR in thyroid carcinoma in comparison with benign thyroid disease and control group. The aim of this study is to detect, quantify and analyze the clinicopathological correlation of those genes in patients with thyroid carcinoma. The results showed a significant increase of TGFα in thyroid patients comparing with control group and benign neoplasms, and between control group and benign neoplasms (p0.05). Our results concluded that there is a strong relationship between TGFα overexpression with thyroid carcinogenesis. VL - 5 IS - 2 ER -
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