Serological Detection of <i>Helicobacter pylori</i> Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria

Abdulhadi Sale Kumurya

doi:doi:10.11648/j.ajhr.20150306.16

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Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria

Abdulhadi Sale Kumurya

Published in American Journal of Health Research (Volume 3, Issue 6)

Received: 31 August 2015 Accepted: 16 September 2015 Published: 17 November 2015

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Abstract

Background: Helicobacter pylori is a major gastroduodenal pathogen and its seropositivity is associated with increased risk of development of human active chronic gastritis, peptic and duodenal ulcer and gastric cancer. Objectives: The aim of this study was to determine the seroprevalence of H. pylori infection among subjects with gastrointestinal problems. Methods: From May 2014 to October 2014, a seroprevalence study was carried out among 100 subjects who had clinical gastric symptoms, with a mean age of 37.77 years (range, 2 to 70 years). Serum samples collected from 44 male and 56 female were screened for detection of anti H. pylori IgG using commercial DIAQUICK Helicobacter pylori (manufactured by DIALAB Production, GMBH) kit. Statistical analyses were performed using SAS software, version 9.1 (SAS Institute Inc., Cary, NC). Results: The overall seropositivity rate of anti H. pylori IgG was 53%. Seropositivity of anti H. pylori IgG increased markedly with age and highest infection rate (96%) was seen in individuals 40 to 50 years old. Anti H. pylori IgA was also correlated with increasing age. Analysis of results for gender showed that there were no significant differences in seropositivity to H. pylori between men and woman (p>0.05) but there was a significant correlation between anti H. pylori IgG and age of subjects (p<0.01). Analysis of results for inflammatory markers (WBC and ESR) showed normal mean of WBC count(7000 cells/ml) and ESR rate (8mm/h) levels in these subjects. No association was detected between H. pylori seropositivity, gender and inflammatory laboratory parameters. Conclusion: This study revealed the high prevalence of H. pylori infection among symptomatic subjects in the study area suggesting necessity of screening for H. pylori infection in symptomatic patients. The results also did not show any strict relations between H. pylori seropositivity, gender and inflammatory markers.

Published in	American Journal of Health Research (Volume 3, Issue 6)
DOI	10.11648/j.ajhr.20150306.16
Page(s)	352-355
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Helicobacter pylori, Seroprevalence, IgG, Gastritis, Nigeria

References

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APA Style

Abdulhadi Sale Kumurya. (2015). Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria. American Journal of Health Research, 3(6), 352-355. https://doi.org/10.11648/j.ajhr.20150306.16

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Abdulhadi Sale Kumurya. Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria. Am. J. Health Res. 2015, 3(6), 352-355. doi: 10.11648/j.ajhr.20150306.16

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AMA Style

Abdulhadi Sale Kumurya. Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria. Am J Health Res. 2015;3(6):352-355. doi: 10.11648/j.ajhr.20150306.16

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@article{10.11648/j.ajhr.20150306.16,
  author = {Abdulhadi Sale Kumurya},
  title = {Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria},
  journal = {American Journal of Health Research},
  volume = {3},
  number = {6},
  pages = {352-355},
  doi = {10.11648/j.ajhr.20150306.16},
  url = {https://doi.org/10.11648/j.ajhr.20150306.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20150306.16},
  abstract = {Background: Helicobacter pylori is a major gastroduodenal pathogen and its seropositivity is associated with increased risk of development of human active chronic gastritis, peptic and duodenal ulcer and gastric cancer. Objectives: The aim of this study was to determine the seroprevalence of H. pylori infection among subjects with gastrointestinal problems. Methods: From May 2014 to October 2014, a seroprevalence study was carried out among 100 subjects who had clinical gastric symptoms, with a mean age of 37.77 years (range, 2 to 70 years). Serum samples collected from 44 male and 56 female were screened for detection of anti H. pylori IgG using commercial DIAQUICK Helicobacter pylori (manufactured by DIALAB Production, GMBH) kit. Statistical analyses were performed using SAS software, version 9.1 (SAS Institute Inc., Cary, NC). Results: The overall seropositivity rate of anti H. pylori IgG was 53%. Seropositivity of anti H. pylori IgG increased markedly with age and highest infection rate (96%) was seen in individuals 40 to 50 years old. Anti H. pylori IgA was also correlated with increasing age. Analysis of results for gender showed that there were no significant differences in seropositivity to H. pylori between men and woman (p>0.05) but there was a significant correlation between anti H. pylori IgG and age of subjects (pH. pylori seropositivity, gender and inflammatory laboratory parameters. Conclusion: This study revealed the high prevalence of H. pylori infection among symptomatic subjects in the study area suggesting necessity of screening for H. pylori infection in symptomatic patients. The results also did not show any strict relations between H. pylori seropositivity, gender and inflammatory markers.},
 year = {2015}
}

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TY - JOUR
T1 - Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria
AU - Abdulhadi Sale Kumurya
Y1 - 2015/11/17
PY - 2015
N1 - https://doi.org/10.11648/j.ajhr.20150306.16
DO - 10.11648/j.ajhr.20150306.16
T2 - American Journal of Health Research
JF - American Journal of Health Research
JO - American Journal of Health Research
SP - 352
EP - 355
PB - Science Publishing Group
SN - 2330-8796
UR - https://doi.org/10.11648/j.ajhr.20150306.16
AB - Background: Helicobacter pylori is a major gastroduodenal pathogen and its seropositivity is associated with increased risk of development of human active chronic gastritis, peptic and duodenal ulcer and gastric cancer. Objectives: The aim of this study was to determine the seroprevalence of H. pylori infection among subjects with gastrointestinal problems. Methods: From May 2014 to October 2014, a seroprevalence study was carried out among 100 subjects who had clinical gastric symptoms, with a mean age of 37.77 years (range, 2 to 70 years). Serum samples collected from 44 male and 56 female were screened for detection of anti H. pylori IgG using commercial DIAQUICK Helicobacter pylori (manufactured by DIALAB Production, GMBH) kit. Statistical analyses were performed using SAS software, version 9.1 (SAS Institute Inc., Cary, NC). Results: The overall seropositivity rate of anti H. pylori IgG was 53%. Seropositivity of anti H. pylori IgG increased markedly with age and highest infection rate (96%) was seen in individuals 40 to 50 years old. Anti H. pylori IgA was also correlated with increasing age. Analysis of results for gender showed that there were no significant differences in seropositivity to H. pylori between men and woman (p>0.05) but there was a significant correlation between anti H. pylori IgG and age of subjects (pH. pylori seropositivity, gender and inflammatory laboratory parameters. Conclusion: This study revealed the high prevalence of H. pylori infection among symptomatic subjects in the study area suggesting necessity of screening for H. pylori infection in symptomatic patients. The results also did not show any strict relations between H. pylori seropositivity, gender and inflammatory markers.
VL - 3
IS - 6
ER -

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Abdulhadi Sale Kumurya

Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Bayero University, Kano, Nigeria

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APA Style

Abdulhadi Sale Kumurya. (2015). Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria. American Journal of Health Research, 3(6), 352-355. https://doi.org/10.11648/j.ajhr.20150306.16

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ACS Style

Abdulhadi Sale Kumurya. Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria. Am. J. Health Res. 2015, 3(6), 352-355. doi: 10.11648/j.ajhr.20150306.16

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AMA Style

Abdulhadi Sale Kumurya. Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria. Am J Health Res. 2015;3(6):352-355. doi: 10.11648/j.ajhr.20150306.16

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@article{10.11648/j.ajhr.20150306.16,
  author = {Abdulhadi Sale Kumurya},
  title = {Serological Detection of Helicobacter pylori Antibodies in Patients Suffering from Gastric Symptoms in Kano, Nigeria},
  journal = {American Journal of Health Research},
  volume = {3},
  number = {6},
  pages = {352-355},
  doi = {10.11648/j.ajhr.20150306.16},
  url = {https://doi.org/10.11648/j.ajhr.20150306.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20150306.16},
  abstract = {Background: Helicobacter pylori is a major gastroduodenal pathogen and its seropositivity is associated with increased risk of development of human active chronic gastritis, peptic and duodenal ulcer and gastric cancer. Objectives: The aim of this study was to determine the seroprevalence of H. pylori infection among subjects with gastrointestinal problems. Methods: From May 2014 to October 2014, a seroprevalence study was carried out among 100 subjects who had clinical gastric symptoms, with a mean age of 37.77 years (range, 2 to 70 years). Serum samples collected from 44 male and 56 female were screened for detection of anti H. pylori IgG using commercial DIAQUICK Helicobacter pylori (manufactured by DIALAB Production, GMBH) kit. Statistical analyses were performed using SAS software, version 9.1 (SAS Institute Inc., Cary, NC). Results: The overall seropositivity rate of anti H. pylori IgG was 53%. Seropositivity of anti H. pylori IgG increased markedly with age and highest infection rate (96%) was seen in individuals 40 to 50 years old. Anti H. pylori IgA was also correlated with increasing age. Analysis of results for gender showed that there were no significant differences in seropositivity to H. pylori between men and woman (p>0.05) but there was a significant correlation between anti H. pylori IgG and age of subjects (pH. pylori seropositivity, gender and inflammatory laboratory parameters. Conclusion: This study revealed the high prevalence of H. pylori infection among symptomatic subjects in the study area suggesting necessity of screening for H. pylori infection in symptomatic patients. The results also did not show any strict relations between H. pylori seropositivity, gender and inflammatory markers.},
 year = {2015}
}

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