The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis

Rongqin Dai; Jinbiao Zhang; Wei Li; Xiangxing Lu; Wenyan Tian

doi:doi:10.11648/j.ajbls.20200804.17

| Peer-Reviewed

The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis

Rongqin Dai, Jinbiao Zhang, Wei Li, Xiangxing Lu, Wenyan Tian

Published in American Journal of Biomedical and Life Sciences (Volume 8, Issue 4)

Received: 16 July 2020 Accepted: Published: 25 August 2020

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Objective: To assess the relationship between thyroid function and T lymphocyte subsets in Patients with Hashimoto's Thyroiditis. Method: To select 131 diagnosed HT patients as the research object, which is divided into HT hyperthyroidism group (Group A) with 18 cases, normal HT thyroid function group (Group B) with 35 cases, HT subclinical hypothyroidism group (Group C) with 42 cases, and HT hypothyroidism group (Group D) with 36 cases in accordance with thyroid function. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, and FCM is adopted to test T lymphocyte subsets. Result: Compare CD3⁺T lymphocytes of each group, Group D is obviously higher than Group A, Group B, and the control group, and the difference has statistic significance (P<0.05); Compare CD3⁺CD4⁺T lymphocyte and CD4⁺/CD8⁺ of each group, Group D is obviously higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group A and Group B are obviously higher than the control group, and the differences have statistic significance (P<0.05); Compare CD3⁺CD8⁺T lymphocytes of each group, Group D is obviously lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, the difference has statistic significance (P<0.05). The correlation analysis shows that TSH is in positive correlation with CD4⁺/CD8⁺, FT3 is in positive correlation with CD3⁺CD8⁺T, and FT4 is in positive correlation with CD3⁺CD8⁺T and in negative correlation with CD4⁺/CD8⁺. Conclusion: HT patients have the imbalance of T lymphocyte subsets, and the T lymphocyte subsets ratio of HT patients of different thyroid function has obvious differences, which may have close relationship with the occurrence and development of HT.

Published in	American Journal of Biomedical and Life Sciences (Volume 8, Issue 4)
DOI	10.11648/j.ajbls.20200804.17
Page(s)	114-118
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis

References

[1]	Ma Qianqian, Liang Qiuhua, Sun Lin, et al. Expression and significance of CD4⁺CD45 RO⁺ memory T cell in peripheral blood of patients with Hashimoto's thyroiditis [J]. Chinese Journal of Immunology, 2016, 32 (10): 1527-1531.
[2]	He Ke, Lu Xiwan, Zhu Lihua, et al. Abnormal proportions of immune regulatory cells in peripheral blood of patients with Hashimoto's Thyroiditis [J]. Chinese Journal of Immunology, 2019, 35 (20): 2513-2516.
[3]	Chong Xianjin, Yu Qingyuan, Aman Guli•Suli Tang, et al. The effect of dexamethasone combined with thyroxine in the treatment of autoimmune thyroiditis and its effect on the related serum cytokines and Th1/Th2 related cytokines [J]. Chinese Journal of Difficult and Complicated Cases, 2018, 17 (11): 1233-1237.
[4]	Guo H, Peng D, Wang Y, et al. A higher frequency of circulating IL-22(+)CD4(+) T cells in Chinese patients with newly diagnosed Hashimoto’s thyroiditis [J]. PLoS One, 2014, 9 (1): e84545.
[5]	Ge Junbo, Xu Yongjian. Internal Medicine [M]. 8th Edition. Beijing: People's Medical Publishing House, 2013: 698.
[6]	Dai Rongqin, Liu Yuzhi, Wang Fengling, et al. The incidence of hashimoto's thyroiditis in medical examination population in Huanghua City, Hebei Province [J]. Chinese Journal of Endemiology, 2019, 38 (2): 140-143.
[7]	Liang Daoyan, Guo Chunyan, Feng Qing, et al. Effects and changes of retinol-binding protein and T cell subsets in children with mycoplasma pneumoniae infection [J]. Chinese Journal of Laboratory Diagnosis, 2018, 22 (12): 2053-2056.
[8]	Wang Xiumin, Dong Yue, Zhao Lei, et al. Clinical effect and influence of combined selenium with soothing liver and activating spleen method on T-lymphocyte subsets in Hashimoto's thyroiditis treatment [J]. Northwest Pharmaceutical Journal, 2017, 32 (6): 779-782.
[9]	Jin Xin, Shang Xuemei, Chen Haibo, et al. Study on dynamic changes and significance of the peripheral blood regulatory T cells (Treg) and Th17 cells in patients with Hashimoto's thyroiditis [J]. Journal of Clinical and Experimental Medicine, 2018, 17 (19): 2092-2094.
[10]	Li Ying, Song Yu, Zhang Tianqi, et al. Relative risk of peripheral blood T lymphocyte subsets variable quantity in psoriasis vulgaris [J]. Chinese Journal of Laboratory Diagnosis, 2019, 23 (7): 1177-1180.
[11]	Jin X, Wang S, Zhao X, et al. Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis [J]. Oncotarget, 2016, 7 (33): 52797-52809.
[12]	Sharma R, Di Dalmazi G, Caturegli P. Exacerbation of autoimmune thyroiditis by CTLA-4 Blockade: a role for IFN-γ induced indoleamine 2, 3-dioxygenase [J]. Thyroid, 2016, 26 (8): 1117-1124.
[13]	Yu Y, Yu N, Lu G, et al. Hashimoto’s thyroiditis with elevated serum IgG₄ concentrations is not equivalent to IgG4 Hashimoto’s thyroiditis [J]. Clin Endocrinol (Oxf), 2018, 88 (6): 943-949.
[14]	Noack M1, Miossec P. Th17 and regulatory T celI balance in autoimmune and infIammatory diseases [J]. Autoimmun Rev, 2014, 13 (6): 668-677.
[15]	Lv Yanli. The Value of Conventional Color Doppler Ultrasound Combined with Ultrasound Elastography in Diagnosing Diffuse Goiter (Graves' Disease) and Hashimoto's Thyroiditis (HT) [J]. Chinese Journal of Ultrasound in Medicine, 2013, 29 (11): 961-964.
[16]	Chen Baoqin, Li Shi, Zhang Jiawei, et al. Significance of serum TPOAb and TGAb in the diagnosis of Hashimoto's thyroiditis and hyperthyroidism [J]. Chinese Journal of Laboratory Diagnosis, 2015, 19 (11): 1932-1933.
[17]	Suciu-Foca N, Manavalan JS, Scotto L, et a1. Molecular characterization of all specific T suppressor and tolerogenic dendritic ceils: review [J]. IntImmunopharmacol, 2005, 5 (1): 7-11.
[18]	Dai Qing, He Jun, Zhang Fan, et al. Expression of IL-1β in peripheral blood of Hashimoto's thyroiditis and its relationship with TGAb and TPOAb [J]. Chinese Journal of Gerontology, 2018, 38 (7): 1574-1575.
[19]	Safdari V, Alijani E, Nemati M, et al. Imbalances in T cell-related transcription factors among patients with Hashimoto’s thyroiditis [J]. Sultan Qaboos Univ Med J, 2017: 17 (2): e174-180.

Cite This Article

Plain Text BibTeX RIS

APA Style

Rongqin Dai, Jinbiao Zhang, Wei Li, Xiangxing Lu, Wenyan Tian. (2020). The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis. American Journal of Biomedical and Life Sciences, 8(4), 114-118. https://doi.org/10.11648/j.ajbls.20200804.17

Copy | Download

ACS Style

Rongqin Dai; Jinbiao Zhang; Wei Li; Xiangxing Lu; Wenyan Tian. The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis. Am. J. Biomed. Life Sci. 2020, 8(4), 114-118. doi: 10.11648/j.ajbls.20200804.17

Copy | Download

AMA Style

Rongqin Dai, Jinbiao Zhang, Wei Li, Xiangxing Lu, Wenyan Tian. The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis. Am J Biomed Life Sci. 2020;8(4):114-118. doi: 10.11648/j.ajbls.20200804.17

Copy | Download

@article{10.11648/j.ajbls.20200804.17,
  author = {Rongqin Dai and Jinbiao Zhang and Wei Li and Xiangxing Lu and Wenyan Tian},
  title = {The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {4},
  pages = {114-118},
  doi = {10.11648/j.ajbls.20200804.17},
  url = {https://doi.org/10.11648/j.ajbls.20200804.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200804.17},
  abstract = {Objective: To assess the relationship between thyroid function and T lymphocyte subsets in Patients with Hashimoto's Thyroiditis. Method: To select 131 diagnosed HT patients as the research object, which is divided into HT hyperthyroidism group (Group A) with 18 cases, normal HT thyroid function group (Group B) with 35 cases, HT subclinical hypothyroidism group (Group C) with 42 cases, and HT hypothyroidism group (Group D) with 36 cases in accordance with thyroid function. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, and FCM is adopted to test T lymphocyte subsets. Result: Compare CD3+T lymphocytes of each group, Group D is obviously higher than Group A, Group B, and the control group, and the difference has statistic significance (P+CD4+T lymphocyte and CD4+/CD8+ of each group, Group D is obviously higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group A and Group B are obviously higher than the control group, and the differences have statistic significance (P+CD8+T lymphocytes of each group, Group D is obviously lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, the difference has statistic significance (P+/CD8+, FT3 is in positive correlation with CD3+CD8+T, and FT4 is in positive correlation with CD3+CD8+T and in negative correlation with CD4+/CD8+. Conclusion: HT patients have the imbalance of T lymphocyte subsets, and the T lymphocyte subsets ratio of HT patients of different thyroid function has obvious differences, which may have close relationship with the occurrence and development of HT.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis
AU  - Rongqin Dai
AU  - Jinbiao Zhang
AU  - Wei Li
AU  - Xiangxing Lu
AU  - Wenyan Tian
Y1  - 2020/08/25
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbls.20200804.17
DO  - 10.11648/j.ajbls.20200804.17
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 114
EP  - 118
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20200804.17
AB  - Objective: To assess the relationship between thyroid function and T lymphocyte subsets in Patients with Hashimoto's Thyroiditis. Method: To select 131 diagnosed HT patients as the research object, which is divided into HT hyperthyroidism group (Group A) with 18 cases, normal HT thyroid function group (Group B) with 35 cases, HT subclinical hypothyroidism group (Group C) with 42 cases, and HT hypothyroidism group (Group D) with 36 cases in accordance with thyroid function. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, and FCM is adopted to test T lymphocyte subsets. Result: Compare CD3+T lymphocytes of each group, Group D is obviously higher than Group A, Group B, and the control group, and the difference has statistic significance (P+CD4+T lymphocyte and CD4+/CD8+ of each group, Group D is obviously higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group A and Group B are obviously higher than the control group, and the differences have statistic significance (P+CD8+T lymphocytes of each group, Group D is obviously lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, the difference has statistic significance (P+/CD8+, FT3 is in positive correlation with CD3+CD8+T, and FT4 is in positive correlation with CD3+CD8+T and in negative correlation with CD4+/CD8+. Conclusion: HT patients have the imbalance of T lymphocyte subsets, and the T lymphocyte subsets ratio of HT patients of different thyroid function has obvious differences, which may have close relationship with the occurrence and development of HT.
VL  - 8
IS  - 4
ER  -

Copy | Download

Author Information

Rongqin Dai

Institute of Thyroid Disease Affiliated to Cangzhou Medical College, Cangzhou, China
Jinbiao Zhang

Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Wei Li

Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Xiangxing Lu

Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Wenyan Tian

Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Rongqin Dai, Jinbiao Zhang, Wei Li, Xiangxing Lu, Wenyan Tian. (2020). The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis. American Journal of Biomedical and Life Sciences, 8(4), 114-118. https://doi.org/10.11648/j.ajbls.20200804.17

Copy | Download

ACS Style

Rongqin Dai; Jinbiao Zhang; Wei Li; Xiangxing Lu; Wenyan Tian. The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis. Am. J. Biomed. Life Sci. 2020, 8(4), 114-118. doi: 10.11648/j.ajbls.20200804.17

Copy | Download

AMA Style

Rongqin Dai, Jinbiao Zhang, Wei Li, Xiangxing Lu, Wenyan Tian. The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis. Am J Biomed Life Sci. 2020;8(4):114-118. doi: 10.11648/j.ajbls.20200804.17

Copy | Download

@article{10.11648/j.ajbls.20200804.17,
  author = {Rongqin Dai and Jinbiao Zhang and Wei Li and Xiangxing Lu and Wenyan Tian},
  title = {The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {8},
  number = {4},
  pages = {114-118},
  doi = {10.11648/j.ajbls.20200804.17},
  url = {https://doi.org/10.11648/j.ajbls.20200804.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20200804.17},
  abstract = {Objective: To assess the relationship between thyroid function and T lymphocyte subsets in Patients with Hashimoto's Thyroiditis. Method: To select 131 diagnosed HT patients as the research object, which is divided into HT hyperthyroidism group (Group A) with 18 cases, normal HT thyroid function group (Group B) with 35 cases, HT subclinical hypothyroidism group (Group C) with 42 cases, and HT hypothyroidism group (Group D) with 36 cases in accordance with thyroid function. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, and FCM is adopted to test T lymphocyte subsets. Result: Compare CD3+T lymphocytes of each group, Group D is obviously higher than Group A, Group B, and the control group, and the difference has statistic significance (P+CD4+T lymphocyte and CD4+/CD8+ of each group, Group D is obviously higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group A and Group B are obviously higher than the control group, and the differences have statistic significance (P+CD8+T lymphocytes of each group, Group D is obviously lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, the difference has statistic significance (P+/CD8+, FT3 is in positive correlation with CD3+CD8+T, and FT4 is in positive correlation with CD3+CD8+T and in negative correlation with CD4+/CD8+. Conclusion: HT patients have the imbalance of T lymphocyte subsets, and the T lymphocyte subsets ratio of HT patients of different thyroid function has obvious differences, which may have close relationship with the occurrence and development of HT.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis
AU  - Rongqin Dai
AU  - Jinbiao Zhang
AU  - Wei Li
AU  - Xiangxing Lu
AU  - Wenyan Tian
Y1  - 2020/08/25
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbls.20200804.17
DO  - 10.11648/j.ajbls.20200804.17
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 114
EP  - 118
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20200804.17
AB  - Objective: To assess the relationship between thyroid function and T lymphocyte subsets in Patients with Hashimoto's Thyroiditis. Method: To select 131 diagnosed HT patients as the research object, which is divided into HT hyperthyroidism group (Group A) with 18 cases, normal HT thyroid function group (Group B) with 35 cases, HT subclinical hypothyroidism group (Group C) with 42 cases, and HT hypothyroidism group (Group D) with 36 cases in accordance with thyroid function. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, and FCM is adopted to test T lymphocyte subsets. Result: Compare CD3+T lymphocytes of each group, Group D is obviously higher than Group A, Group B, and the control group, and the difference has statistic significance (P+CD4+T lymphocyte and CD4+/CD8+ of each group, Group D is obviously higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group A and Group B are obviously higher than the control group, and the differences have statistic significance (P+CD8+T lymphocytes of each group, Group D is obviously lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, the difference has statistic significance (P+/CD8+, FT3 is in positive correlation with CD3+CD8+T, and FT4 is in positive correlation with CD3+CD8+T and in negative correlation with CD4+/CD8+. Conclusion: HT patients have the imbalance of T lymphocyte subsets, and the T lymphocyte subsets ratio of HT patients of different thyroid function has obvious differences, which may have close relationship with the occurrence and development of HT.
VL  - 8
IS  - 4
ER  -

Copy | Download