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Potentials of Encapsulated Flavonoids in Biologics: A Review
American Journal of Biomedical and Life Sciences
Volume 8, Issue 4, August 2020, Pages: 97-113
Received: Jul. 9, 2020; Accepted: Jul. 25, 2020; Published: Aug. 25, 2020
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Mahesh Dattatraya Dere, Department of Chemistry, Savitribai Phule Pune University, Pune, India
Ayesha Alim Khan, Department of Chemistry, Savitribai Phule Pune University, Pune, India
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Flavonoids are a versatile class of natural polyphenolic compounds that represent secondary metabolites from higher plants. Their basic structures consists of fifteen-carbon skeleton consisting of two benzene rings (A and B) linked via a heterocyclic pyrane ring (C) to produce a series of subclass compounds such as flavones, flavonols, flavanones, isoflavones, flavanols or catechins and anthocyanins. Their biological activities are dependent on the structure, chemical nature and degree of hydroxylation, substitutions, conjugation and degree of polymerization. A brief description of flavonoids, its source and classification have been described. Although flavonoids are integral in nutraceutical, pharmaceutical, medicinal, cosmetic and other applications their bioavailability to the target tissues and cells are restricted due to poor water solubility and enzymatic degradation. To increase effectiveness, currently encapsulation of the drug candidate in biological material that are able to enhance the potential health benefits by increasing the water solubility and targeted delivery are being achieved. Biodegradable natural, synthetic and semi-synthetic material/ polymers approved by the US Food and Drug Administration (FDA) for use in the preparation of nanodrugs as well as the applied encapsulation technique are discussed that prevent against oxidation, isomerization and degradation of the flavanoids. The aim of this review is to identify specific flavonoids that exhibit increased pharmacological and biological efficiencies on encapsulation. Thus, these potential drugs may help in preventing many chronic diseases and lead to future research directions.
Flavonoids, Encapsulation, Delivery Systems, Biological Activity
To cite this article
Mahesh Dattatraya Dere, Ayesha Alim Khan, Potentials of Encapsulated Flavonoids in Biologics: A Review, American Journal of Biomedical and Life Sciences. Vol. 8, No. 4, 2020, pp. 97-113. doi: 10.11648/j.ajbls.20200804.16
Copyright © 2020 Authors retain the copyright of this article.
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10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186