American Journal of Biomedical and Life Sciences

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Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats

Received: 16 October 2019    Accepted: 08 November 2019    Published: 27 November 2019
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Abstract

Traditional medicine has received considerable acceptance in recent years, especially in Africa probably due to perceived efficacy and the fact that they are a cheap source of medicine. It can also be attributed to the pharmacological properties of plants, including antioxidant and hepatoprotective properties. The hepatoprotective effects of aqueous extract and 10% ethanolic extract of the roots of Mitracarpus scaber against paracetamol (PCM)-induced hepatotoxicity in Wistar rats of both sexes were investigated. Liver damage was induced by oral administration of 1.5mg/kg bodyweight of PCM. After pre-treatment for 6 days with aqueous and ethanolic extract of Mitracarpus scaber root (200 and 500mg/kg), hepatoprotective properties of the plant was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), followed by histopathology, as compared with the control group (group induced with liver damage but not treated). Administration of the extracts showed significant (p<0.05) and dose-dependent hepatoprotective activity resulting in decrease in the activity of ALT and AST. These data revealed that the roots of Mitracarpus scaber aqueous and ethanolic extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.

DOI 10.11648/j.ajbls.20190706.14
Published in American Journal of Biomedical and Life Sciences (Volume 7, Issue 6, December 2019)
Page(s) 148-154
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Mitracarpus scaber, Roots, Paracetamol, Hepatoprotection, Medicinal Plants

References
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Author Information
  • Department of Biochemistry, Faculty of Natural and Applied Sciences, Plateau State University, Bokkos, Nigeria

  • Department of Biochemistry, Faculty of Natural and Applied Sciences, Plateau State University, Bokkos, Nigeria

  • Department of Biochemistry, Faculty of Natural and Applied Sciences, Plateau State University, Bokkos, Nigeria

  • Department of Chemistry, Faculty of Natural and Applied Scinces, Plateau State University, Bokkos, Nigeria

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    Okonkwo Francis Obiora, Jonathan Bege, Ibibra Joel Agat, Nvau John Barnabas. (2019). Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats. American Journal of Biomedical and Life Sciences, 7(6), 148-154. https://doi.org/10.11648/j.ajbls.20190706.14

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    ACS Style

    Okonkwo Francis Obiora; Jonathan Bege; Ibibra Joel Agat; Nvau John Barnabas. Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats. Am. J. Biomed. Life Sci. 2019, 7(6), 148-154. doi: 10.11648/j.ajbls.20190706.14

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    AMA Style

    Okonkwo Francis Obiora, Jonathan Bege, Ibibra Joel Agat, Nvau John Barnabas. Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats. Am J Biomed Life Sci. 2019;7(6):148-154. doi: 10.11648/j.ajbls.20190706.14

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  • @article{10.11648/j.ajbls.20190706.14,
      author = {Okonkwo Francis Obiora and Jonathan Bege and Ibibra Joel Agat and Nvau John Barnabas},
      title = {Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {7},
      number = {6},
      pages = {148-154},
      doi = {10.11648/j.ajbls.20190706.14},
      url = {https://doi.org/10.11648/j.ajbls.20190706.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajbls.20190706.14},
      abstract = {Traditional medicine has received considerable acceptance in recent years, especially in Africa probably due to perceived efficacy and the fact that they are a cheap source of medicine. It can also be attributed to the pharmacological properties of plants, including antioxidant and hepatoprotective properties. The hepatoprotective effects of aqueous extract and 10% ethanolic extract of the roots of Mitracarpus scaber against paracetamol (PCM)-induced hepatotoxicity in Wistar rats of both sexes were investigated. Liver damage was induced by oral administration of 1.5mg/kg bodyweight of PCM. After pre-treatment for 6 days with aqueous and ethanolic extract of Mitracarpus scaber root (200 and 500mg/kg), hepatoprotective properties of the plant was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), followed by histopathology, as compared with the control group (group induced with liver damage but not treated). Administration of the extracts showed significant (pMitracarpus scaber aqueous and ethanolic extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.},
     year = {2019}
    }
    

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    T1  - Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats
    AU  - Okonkwo Francis Obiora
    AU  - Jonathan Bege
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    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
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    PB  - Science Publishing Group
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    AB  - Traditional medicine has received considerable acceptance in recent years, especially in Africa probably due to perceived efficacy and the fact that they are a cheap source of medicine. It can also be attributed to the pharmacological properties of plants, including antioxidant and hepatoprotective properties. The hepatoprotective effects of aqueous extract and 10% ethanolic extract of the roots of Mitracarpus scaber against paracetamol (PCM)-induced hepatotoxicity in Wistar rats of both sexes were investigated. Liver damage was induced by oral administration of 1.5mg/kg bodyweight of PCM. After pre-treatment for 6 days with aqueous and ethanolic extract of Mitracarpus scaber root (200 and 500mg/kg), hepatoprotective properties of the plant was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), followed by histopathology, as compared with the control group (group induced with liver damage but not treated). Administration of the extracts showed significant (pMitracarpus scaber aqueous and ethanolic extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.
    VL  - 7
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