Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats

Meraiyebu Ajibola; Olaniyan Olugbemi; Abutu Stephanie; Dare Joseph; Atsukwei Denen

doi:doi:10.11648/j.ajbls.20130104.12

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Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats

Meraiyebu Ajibola, Olaniyan Olugbemi, Abutu Stephanie, Dare Joseph, Atsukwei Denen

Published in American Journal of Biomedical and Life Sciences (Volume 1, Issue 4)

Received: 5 October 2013 Accepted: Published: 10 December 2013

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Abstract

This study was designed to investigate the effect of the methanolic extract of parkia biglobosa stem bark on a single daily dose of oral administration of 500 mg/kg BW of paracetamol (acetaminophen, PCM) induced hepatotoxicity in wistar rats. The rats were divided into (5 groups. The rats in group I served as control and received distilled water, group II were given orally a single daily dose of 500 mg/kg BW of paracetamol for 7 days. Group III, IV, and V received a single daily dose of 500 mg/kg BW of paracetamol and then treated orally with 140 mg/kg BW acetylcysteine, 100 mg/kg BW low dose and 200 mg/kg BW high dose of parkia biglobosa respectively for 21 days. The activities of liver function marker enzymes were determined in the serum of the rat liver homogenate. Paracetamol caused liver damage as evident by significant increased (p≤0.05) (49.63±1.99; 39.41±1.99; 78.58±1.72) in the serum levels of Alkaline phosphatase (AP), Aspartate transaminase (AST) and Alanine transaminase (ALT) respectively. Low dose 100mg/kg BW of Parkia biglobosa significantly increased (p≤0.05) serum AP levels (65.42±1.6) but significantly reduced serum levels of ALT and AST (43.80±2.4; 36.77±1.58) respectively. High dose 200 mg/kg BW of Parkia biglobosa significantly reduced (p≤0.05) serum levels of AP, ALT and AST (26.58±0.34; 33.68±2.02; 31.08±0.34) respectively. Acetylcysteine (standard reference drug) significantly reduced (p≤0.05) ALT and AST levels (43.46±1.67; 30.10±1.01) respectively, but the reduction in AP level (46.64±1.01) was not significant. The activity of parkia biglobosa is comparable with acetylcysteine, a known hepatoprotective drug. Thus, Parkia biglobosa exhibits hepatoprotective activity against paracetamol toxicity.

Published in	American Journal of Biomedical and Life Sciences (Volume 1, Issue 4)
DOI	10.11648/j.ajbls.20130104.12
Page(s)	75-78
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Parkia Biglobosa, Paracetamol, Liver Function Enzyme Markers, Acetylcysteine, Wistar Rats

References

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Meraiyebu Ajibola, Olaniyan Olugbemi, Abutu Stephanie, Dare Joseph, Atsukwei Denen. (2013). Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats. American Journal of Biomedical and Life Sciences, 1(4), 75-78. https://doi.org/10.11648/j.ajbls.20130104.12

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ACS Style

Meraiyebu Ajibola; Olaniyan Olugbemi; Abutu Stephanie; Dare Joseph; Atsukwei Denen. Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats. Am. J. Biomed. Life Sci. 2013, 1(4), 75-78. doi: 10.11648/j.ajbls.20130104.12

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AMA Style

Meraiyebu Ajibola, Olaniyan Olugbemi, Abutu Stephanie, Dare Joseph, Atsukwei Denen. Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats. Am J Biomed Life Sci. 2013;1(4):75-78. doi: 10.11648/j.ajbls.20130104.12

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@article{10.11648/j.ajbls.20130104.12,
  author = {Meraiyebu Ajibola and Olaniyan Olugbemi and Abutu Stephanie and Dare Joseph and Atsukwei Denen},
  title = {Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {1},
  number = {4},
  pages = {75-78},
  doi = {10.11648/j.ajbls.20130104.12},
  url = {https://doi.org/10.11648/j.ajbls.20130104.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20130104.12},
  abstract = {This study was designed to investigate the effect of the methanolic extract of parkia biglobosa stem bark on a single daily dose of oral administration of 500 mg/kg BW of paracetamol (acetaminophen, PCM) induced hepatotoxicity in wistar rats. The rats were divided into (5 groups. The rats in group I served as control and received distilled water, group II were given orally a single daily dose of 500 mg/kg BW of paracetamol for 7 days. Group III, IV, and V received a single daily dose of 500 mg/kg BW of paracetamol and then treated orally with 140 mg/kg BW acetylcysteine, 100 mg/kg BW low dose and 200 mg/kg BW high dose of parkia biglobosa respectively for 21 days. The activities of liver function marker enzymes were determined in the serum of the rat liver homogenate. Paracetamol caused liver damage as evident by significant increased (p≤0.05) (49.63±1.99; 39.41±1.99; 78.58±1.72) in the serum levels of Alkaline phosphatase (AP), Aspartate transaminase (AST) and Alanine transaminase (ALT) respectively. Low dose 100mg/kg BW of Parkia biglobosa significantly increased (p≤0.05) serum AP levels (65.42±1.6) but significantly reduced serum levels of ALT and AST (43.80±2.4; 36.77±1.58) respectively. High dose 200 mg/kg BW of Parkia biglobosa significantly reduced (p≤0.05) serum levels of AP, ALT and AST (26.58±0.34; 33.68±2.02; 31.08±0.34) respectively. Acetylcysteine (standard reference drug) significantly reduced (p≤0.05) ALT and AST levels (43.46±1.67; 30.10±1.01) respectively, but the reduction in AP level (46.64±1.01) was not significant. The activity of parkia biglobosa is comparable with acetylcysteine, a known hepatoprotective drug.  Thus, Parkia biglobosa exhibits hepatoprotective activity against paracetamol toxicity.},
 year = {2013}
}

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TY  - JOUR
T1  - Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats
AU  - Meraiyebu Ajibola
AU  - Olaniyan Olugbemi
AU  - Abutu Stephanie
AU  - Dare Joseph
AU  - Atsukwei Denen
Y1  - 2013/12/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbls.20130104.12
DO  - 10.11648/j.ajbls.20130104.12
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 75
EP  - 78
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20130104.12
AB  - This study was designed to investigate the effect of the methanolic extract of parkia biglobosa stem bark on a single daily dose of oral administration of 500 mg/kg BW of paracetamol (acetaminophen, PCM) induced hepatotoxicity in wistar rats. The rats were divided into (5 groups. The rats in group I served as control and received distilled water, group II were given orally a single daily dose of 500 mg/kg BW of paracetamol for 7 days. Group III, IV, and V received a single daily dose of 500 mg/kg BW of paracetamol and then treated orally with 140 mg/kg BW acetylcysteine, 100 mg/kg BW low dose and 200 mg/kg BW high dose of parkia biglobosa respectively for 21 days. The activities of liver function marker enzymes were determined in the serum of the rat liver homogenate. Paracetamol caused liver damage as evident by significant increased (p≤0.05) (49.63±1.99; 39.41±1.99; 78.58±1.72) in the serum levels of Alkaline phosphatase (AP), Aspartate transaminase (AST) and Alanine transaminase (ALT) respectively. Low dose 100mg/kg BW of Parkia biglobosa significantly increased (p≤0.05) serum AP levels (65.42±1.6) but significantly reduced serum levels of ALT and AST (43.80±2.4; 36.77±1.58) respectively. High dose 200 mg/kg BW of Parkia biglobosa significantly reduced (p≤0.05) serum levels of AP, ALT and AST (26.58±0.34; 33.68±2.02; 31.08±0.34) respectively. Acetylcysteine (standard reference drug) significantly reduced (p≤0.05) ALT and AST levels (43.46±1.67; 30.10±1.01) respectively, but the reduction in AP level (46.64±1.01) was not significant. The activity of parkia biglobosa is comparable with acetylcysteine, a known hepatoprotective drug.  Thus, Parkia biglobosa exhibits hepatoprotective activity against paracetamol toxicity.
VL  - 1
IS  - 4
ER  -

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Author Information

Meraiyebu Ajibola

Department of Physiology, Bingham University, Karu, Nasarawa, Nigeria
Olaniyan Olugbemi

Department of Physiology, Bingham University, Karu, Nasarawa, Nigeria
Abutu Stephanie

Department of Physiology, Bingham University, Karu, Nasarawa, Nigeria
Dare Joseph

Department of Anatomy, Bingham University, Karu, Nasarawa, Nigeria
Atsukwei Denen

Department of Physiology, Bingham University, Karu, Nasarawa, Nigeria

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Meraiyebu Ajibola, Olaniyan Olugbemi, Abutu Stephanie, Dare Joseph, Atsukwei Denen. (2013). Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats. American Journal of Biomedical and Life Sciences, 1(4), 75-78. https://doi.org/10.11648/j.ajbls.20130104.12

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ACS Style

Meraiyebu Ajibola; Olaniyan Olugbemi; Abutu Stephanie; Dare Joseph; Atsukwei Denen. Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats. Am. J. Biomed. Life Sci. 2013, 1(4), 75-78. doi: 10.11648/j.ajbls.20130104.12

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AMA Style

Meraiyebu Ajibola, Olaniyan Olugbemi, Abutu Stephanie, Dare Joseph, Atsukwei Denen. Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats. Am J Biomed Life Sci. 2013;1(4):75-78. doi: 10.11648/j.ajbls.20130104.12

Copy | Download

@article{10.11648/j.ajbls.20130104.12,
  author = {Meraiyebu Ajibola and Olaniyan Olugbemi and Abutu Stephanie and Dare Joseph and Atsukwei Denen},
  title = {Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {1},
  number = {4},
  pages = {75-78},
  doi = {10.11648/j.ajbls.20130104.12},
  url = {https://doi.org/10.11648/j.ajbls.20130104.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20130104.12},
  abstract = {This study was designed to investigate the effect of the methanolic extract of parkia biglobosa stem bark on a single daily dose of oral administration of 500 mg/kg BW of paracetamol (acetaminophen, PCM) induced hepatotoxicity in wistar rats. The rats were divided into (5 groups. The rats in group I served as control and received distilled water, group II were given orally a single daily dose of 500 mg/kg BW of paracetamol for 7 days. Group III, IV, and V received a single daily dose of 500 mg/kg BW of paracetamol and then treated orally with 140 mg/kg BW acetylcysteine, 100 mg/kg BW low dose and 200 mg/kg BW high dose of parkia biglobosa respectively for 21 days. The activities of liver function marker enzymes were determined in the serum of the rat liver homogenate. Paracetamol caused liver damage as evident by significant increased (p≤0.05) (49.63±1.99; 39.41±1.99; 78.58±1.72) in the serum levels of Alkaline phosphatase (AP), Aspartate transaminase (AST) and Alanine transaminase (ALT) respectively. Low dose 100mg/kg BW of Parkia biglobosa significantly increased (p≤0.05) serum AP levels (65.42±1.6) but significantly reduced serum levels of ALT and AST (43.80±2.4; 36.77±1.58) respectively. High dose 200 mg/kg BW of Parkia biglobosa significantly reduced (p≤0.05) serum levels of AP, ALT and AST (26.58±0.34; 33.68±2.02; 31.08±0.34) respectively. Acetylcysteine (standard reference drug) significantly reduced (p≤0.05) ALT and AST levels (43.46±1.67; 30.10±1.01) respectively, but the reduction in AP level (46.64±1.01) was not significant. The activity of parkia biglobosa is comparable with acetylcysteine, a known hepatoprotective drug.  Thus, Parkia biglobosa exhibits hepatoprotective activity against paracetamol toxicity.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Hepatoprotective Effect of Parkia Biglobosa Stem Bark Methanolic Extract on Paracetamol Induced Liver Damage in Wistar Rats
AU  - Meraiyebu Ajibola
AU  - Olaniyan Olugbemi
AU  - Abutu Stephanie
AU  - Dare Joseph
AU  - Atsukwei Denen
Y1  - 2013/12/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbls.20130104.12
DO  - 10.11648/j.ajbls.20130104.12
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 75
EP  - 78
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20130104.12
AB  - This study was designed to investigate the effect of the methanolic extract of parkia biglobosa stem bark on a single daily dose of oral administration of 500 mg/kg BW of paracetamol (acetaminophen, PCM) induced hepatotoxicity in wistar rats. The rats were divided into (5 groups. The rats in group I served as control and received distilled water, group II were given orally a single daily dose of 500 mg/kg BW of paracetamol for 7 days. Group III, IV, and V received a single daily dose of 500 mg/kg BW of paracetamol and then treated orally with 140 mg/kg BW acetylcysteine, 100 mg/kg BW low dose and 200 mg/kg BW high dose of parkia biglobosa respectively for 21 days. The activities of liver function marker enzymes were determined in the serum of the rat liver homogenate. Paracetamol caused liver damage as evident by significant increased (p≤0.05) (49.63±1.99; 39.41±1.99; 78.58±1.72) in the serum levels of Alkaline phosphatase (AP), Aspartate transaminase (AST) and Alanine transaminase (ALT) respectively. Low dose 100mg/kg BW of Parkia biglobosa significantly increased (p≤0.05) serum AP levels (65.42±1.6) but significantly reduced serum levels of ALT and AST (43.80±2.4; 36.77±1.58) respectively. High dose 200 mg/kg BW of Parkia biglobosa significantly reduced (p≤0.05) serum levels of AP, ALT and AST (26.58±0.34; 33.68±2.02; 31.08±0.34) respectively. Acetylcysteine (standard reference drug) significantly reduced (p≤0.05) ALT and AST levels (43.46±1.67; 30.10±1.01) respectively, but the reduction in AP level (46.64±1.01) was not significant. The activity of parkia biglobosa is comparable with acetylcysteine, a known hepatoprotective drug.  Thus, Parkia biglobosa exhibits hepatoprotective activity against paracetamol toxicity.
VL  - 1
IS  - 4
ER  -

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