Journal of Cancer Treatment and Research

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Immunotherapy Related Adverse Events Predict Treatment Response

Received: 17 May 2020    Accepted: 28 May 2020    Published: 09 June 2020
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Abstract

Immunotherapy blocks immunoinhibitory pathways and allows for reversal of immunosuppression caused by malignant tumors. Immunotherapy can cause immune-related adverse events (IrAE) including rash, pneumonitis, colitis endocrinopathy, nephritis, adrenal insufficiency, hepatitis, and uveitis. Limited data exist to predict which patients will have the greatest response to therapy and if there is a correlation between IrAE and immunotherapy effectiveness. The aim of this study was to determine the relationship between IrAE and immunotherapy efficacy. A retrospective medical records review was collected of patients with metastatic cancer who received immunotherapy. Data included demographics, Eastern Cooperative Oncology Group Performance Status, imaging, time on treatment, best response, disease progression, and presence or absence of IrAE while on treatment. Treatment response was analyzed using the Response Evaluation Criteria in Solid Tumors guideline, version 1.1. Overall survival probabilities were calculated by the Kaplan-Meier survival method. 456 patients were included for analysis, 175 (38.4%) had an IrAE while on immunotherapy. The development of IrAE correlated with response rate for complete response, partial response, and overall response rate. A significant increase in overall survival was also seen. The presence of IrAE may be a potential predictive indicator for treatment response to immune checkpoint inhibitors.

DOI 10.11648/j.jctr.20200802.13
Published in Journal of Cancer Treatment and Research (Volume 8, Issue 2, June 2020)
Page(s) 45-50
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Immunotherapy, Adverse Events, Neoplasms, Immunology

References
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Author Information
  • Department of Internal Medicine, Ochsner Clinic Foundation, New Orleans, the United States; Ochsner Clinical School, University of Queensland, New Orleans, the United States

  • Department of Internal Medicine, Ochsner Clinic Foundation, New Orleans, the United States; Ochsner Clinical School, University of Queensland, New Orleans, the United States; Department of Hematology Oncology, Louisiana State University Health Sciences Center, New Orleans, the United States

  • Department of Internal Medicine, Ochsner Clinic Foundation, New Orleans, the United States

  • Ochsner Clinical School, University of Queensland, New Orleans, the United States; Department of Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, the United States

  • Center for Outcomes and Health Services Research, Ochsner Clinic Foundation, New Orleans, the United States

  • Ochsner Clinical School, University of Queensland, New Orleans, the United States

  • Department of Hematology/Oncology, Ochsner Cancer Institute, New Orleans, the United States

Cite This Article
  • APA Style

    Diana Maslov, Katharine Thomas, Victoria Simenson, Caitlin Sullivan, Alaa Mohammed, et al. (2020). Immunotherapy Related Adverse Events Predict Treatment Response. Journal of Cancer Treatment and Research, 8(2), 45-50. https://doi.org/10.11648/j.jctr.20200802.13

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    ACS Style

    Diana Maslov; Katharine Thomas; Victoria Simenson; Caitlin Sullivan; Alaa Mohammed, et al. Immunotherapy Related Adverse Events Predict Treatment Response. J. Cancer Treat. Res. 2020, 8(2), 45-50. doi: 10.11648/j.jctr.20200802.13

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    AMA Style

    Diana Maslov, Katharine Thomas, Victoria Simenson, Caitlin Sullivan, Alaa Mohammed, et al. Immunotherapy Related Adverse Events Predict Treatment Response. J Cancer Treat Res. 2020;8(2):45-50. doi: 10.11648/j.jctr.20200802.13

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  • @article{10.11648/j.jctr.20200802.13,
      author = {Diana Maslov and Katharine Thomas and Victoria Simenson and Caitlin Sullivan and Alaa Mohammed and Jessica Boyce and Marc Matrana},
      title = {Immunotherapy Related Adverse Events Predict Treatment Response},
      journal = {Journal of Cancer Treatment and Research},
      volume = {8},
      number = {2},
      pages = {45-50},
      doi = {10.11648/j.jctr.20200802.13},
      url = {https://doi.org/10.11648/j.jctr.20200802.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jctr.20200802.13},
      abstract = {Immunotherapy blocks immunoinhibitory pathways and allows for reversal of immunosuppression caused by malignant tumors. Immunotherapy can cause immune-related adverse events (IrAE) including rash, pneumonitis, colitis endocrinopathy, nephritis, adrenal insufficiency, hepatitis, and uveitis. Limited data exist to predict which patients will have the greatest response to therapy and if there is a correlation between IrAE and immunotherapy effectiveness. The aim of this study was to determine the relationship between IrAE and immunotherapy efficacy. A retrospective medical records review was collected of patients with metastatic cancer who received immunotherapy. Data included demographics, Eastern Cooperative Oncology Group Performance Status, imaging, time on treatment, best response, disease progression, and presence or absence of IrAE while on treatment. Treatment response was analyzed using the Response Evaluation Criteria in Solid Tumors guideline, version 1.1. Overall survival probabilities were calculated by the Kaplan-Meier survival method. 456 patients were included for analysis, 175 (38.4%) had an IrAE while on immunotherapy. The development of IrAE correlated with response rate for complete response, partial response, and overall response rate. A significant increase in overall survival was also seen. The presence of IrAE may be a potential predictive indicator for treatment response to immune checkpoint inhibitors.},
     year = {2020}
    }
    

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    T1  - Immunotherapy Related Adverse Events Predict Treatment Response
    AU  - Diana Maslov
    AU  - Katharine Thomas
    AU  - Victoria Simenson
    AU  - Caitlin Sullivan
    AU  - Alaa Mohammed
    AU  - Jessica Boyce
    AU  - Marc Matrana
    Y1  - 2020/06/09
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    JF  - Journal of Cancer Treatment and Research
    JO  - Journal of Cancer Treatment and Research
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    AB  - Immunotherapy blocks immunoinhibitory pathways and allows for reversal of immunosuppression caused by malignant tumors. Immunotherapy can cause immune-related adverse events (IrAE) including rash, pneumonitis, colitis endocrinopathy, nephritis, adrenal insufficiency, hepatitis, and uveitis. Limited data exist to predict which patients will have the greatest response to therapy and if there is a correlation between IrAE and immunotherapy effectiveness. The aim of this study was to determine the relationship between IrAE and immunotherapy efficacy. A retrospective medical records review was collected of patients with metastatic cancer who received immunotherapy. Data included demographics, Eastern Cooperative Oncology Group Performance Status, imaging, time on treatment, best response, disease progression, and presence or absence of IrAE while on treatment. Treatment response was analyzed using the Response Evaluation Criteria in Solid Tumors guideline, version 1.1. Overall survival probabilities were calculated by the Kaplan-Meier survival method. 456 patients were included for analysis, 175 (38.4%) had an IrAE while on immunotherapy. The development of IrAE correlated with response rate for complete response, partial response, and overall response rate. A significant increase in overall survival was also seen. The presence of IrAE may be a potential predictive indicator for treatment response to immune checkpoint inhibitors.
    VL  - 8
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