Journal of Cancer Treatment and Research

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Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood

Received: 24 May 2018    Accepted: 19 July 2018    Published: 14 August 2018
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Abstract

Most anticancer drugs produce cytotoxicites in cancer cells, but also generate effects in normal cells that create undesirable side effects, especially for immune functioning cells which have already been suppressed by cancer invasion or biological effects. The SB natural anticancer drug is a root extract of the Pulsatilla koreana plant that has been used in Korea as an effective anticancer agent for more than 20 different malignant tumors without triggering significant adverse reactions. We investigated the effects of the SB anticancer drug on human immune cells in cancer patients. 24 consecutive patients, with histologically proven cancers, received SB drug treatments and 20 control patients did not receive SB administrations. Both groups were immunologically tested before and after their SB treatments for 14 days and then weekly for the 3rd, 4th, 5th and 6th weeks thereafter. The total number of white blood cells with differential counts including monocytes and lymphocytes were checked. Immunoassay and flow cytometry were used to analyse CD4 and CD8 T cell percentages, total cell counts with their ratios, as well as CD16/56 natural killer cell percentages and cell counts. Total white blood cell counts normalized within 10 days after the SB drug administrations. The total lymphocyte counts were slightly increased, but remained within normal parameters. CD4 and CD8 T cells, as well as CD 16/56 NK cell percentages, became normal within 10 days; their total cell counts were initially increased (26.3%, 45.2%, and 16.7%, respectively) and then became normal. The SB drug was found to be effective cytoapoptotically and was also effective for immune cell recovery in cancer patients in their initial period of the SB drug treatment. These were patients who had already had a bone marrow suppression by cancer invasion and/or prior chemotherapy.

DOI 10.11648/j.jctr.20180602.13
Published in Journal of Cancer Treatment and Research (Volume 6, Issue 2, June 2018)
Page(s) 25-30
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Initial Effects, The SB Natural Anticancer Drug, NK Cells, CD4+ and CD8+ T Lymphocytes, Human Peripheral Blood

References
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Author Information
  • Department of Internal Medicine, Sahmyook Cancer Center, Sahmyook Seoul Hospital, Seoul, Korea; Department of Internal Medicine, Sahmyook Seoul Hospital, Seoul, Korea

  • Department of Internal Medicine, Sahmyook Cancer Center, Sahmyook Seoul Hospital, Seoul, Korea; Department of Internal Medicine, Sahmyook Seoul Hospital, Seoul, Korea

  • Department of Family Medicine, Sahmyook Seoul Hospital, Seoul, Korea

  • Department of Anatomy, College of Medicine, Seoul National University, Seoul, Korea

  • Department of Medical Oncology, Kyunghee University Hospital, Seoul, Korea; Department of Internal Medicine, East-West Integrative Medicine Hospital, Wien, Austria

  • Department of Medical Oncology, Kyunghee University Hospital, Seoul, Korea; Department of Molecular Medicine, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea; Department of Radiological Sciences, University of California Medical Center, Irvine, USA

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    Jong-Hwa Lee, Yoo-Jin Cho, Myung-Sup Chae, Wang-Jae Lee, U-Hyun Park, et al. (2018). Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood. Journal of Cancer Treatment and Research, 6(2), 25-30. https://doi.org/10.11648/j.jctr.20180602.13

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    ACS Style

    Jong-Hwa Lee; Yoo-Jin Cho; Myung-Sup Chae; Wang-Jae Lee; U-Hyun Park, et al. Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood. J. Cancer Treat. Res. 2018, 6(2), 25-30. doi: 10.11648/j.jctr.20180602.13

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    AMA Style

    Jong-Hwa Lee, Yoo-Jin Cho, Myung-Sup Chae, Wang-Jae Lee, U-Hyun Park, et al. Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood. J Cancer Treat Res. 2018;6(2):25-30. doi: 10.11648/j.jctr.20180602.13

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  • @article{10.11648/j.jctr.20180602.13,
      author = {Jong-Hwa Lee and Yoo-Jin Cho and Myung-Sup Chae and Wang-Jae Lee and U-Hyun Park and Euishin Edmund Kim},
      title = {Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood},
      journal = {Journal of Cancer Treatment and Research},
      volume = {6},
      number = {2},
      pages = {25-30},
      doi = {10.11648/j.jctr.20180602.13},
      url = {https://doi.org/10.11648/j.jctr.20180602.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jctr.20180602.13},
      abstract = {Most anticancer drugs produce cytotoxicites in cancer cells, but also generate effects in normal cells that create undesirable side effects, especially for immune functioning cells which have already been suppressed by cancer invasion or biological effects. The SB natural anticancer drug is a root extract of the Pulsatilla koreana plant that has been used in Korea as an effective anticancer agent for more than 20 different malignant tumors without triggering significant adverse reactions. We investigated the effects of the SB anticancer drug on human immune cells in cancer patients. 24 consecutive patients, with histologically proven cancers, received SB drug treatments and 20 control patients did not receive SB administrations. Both groups were immunologically tested before and after their SB treatments for 14 days and then weekly for the 3rd, 4th, 5th and 6th weeks thereafter. The total number of white blood cells with differential counts including monocytes and lymphocytes were checked. Immunoassay and flow cytometry were used to analyse CD4 and CD8 T cell percentages, total cell counts with their ratios, as well as CD16/56 natural killer cell percentages and cell counts. Total white blood cell counts normalized within 10 days after the SB drug administrations. The total lymphocyte counts were slightly increased, but remained within normal parameters. CD4 and CD8 T cells, as well as CD 16/56 NK cell percentages, became normal within 10 days; their total cell counts were initially increased (26.3%, 45.2%, and 16.7%, respectively) and then became normal. The SB drug was found to be effective cytoapoptotically and was also effective for immune cell recovery in cancer patients in their initial period of the SB drug treatment. These were patients who had already had a bone marrow suppression by cancer invasion and/or prior chemotherapy.},
     year = {2018}
    }
    

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    T1  - Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood
    AU  - Jong-Hwa Lee
    AU  - Yoo-Jin Cho
    AU  - Myung-Sup Chae
    AU  - Wang-Jae Lee
    AU  - U-Hyun Park
    AU  - Euishin Edmund Kim
    Y1  - 2018/08/14
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    T2  - Journal of Cancer Treatment and Research
    JF  - Journal of Cancer Treatment and Research
    JO  - Journal of Cancer Treatment and Research
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    EP  - 30
    PB  - Science Publishing Group
    SN  - 2376-7790
    UR  - https://doi.org/10.11648/j.jctr.20180602.13
    AB  - Most anticancer drugs produce cytotoxicites in cancer cells, but also generate effects in normal cells that create undesirable side effects, especially for immune functioning cells which have already been suppressed by cancer invasion or biological effects. The SB natural anticancer drug is a root extract of the Pulsatilla koreana plant that has been used in Korea as an effective anticancer agent for more than 20 different malignant tumors without triggering significant adverse reactions. We investigated the effects of the SB anticancer drug on human immune cells in cancer patients. 24 consecutive patients, with histologically proven cancers, received SB drug treatments and 20 control patients did not receive SB administrations. Both groups were immunologically tested before and after their SB treatments for 14 days and then weekly for the 3rd, 4th, 5th and 6th weeks thereafter. The total number of white blood cells with differential counts including monocytes and lymphocytes were checked. Immunoassay and flow cytometry were used to analyse CD4 and CD8 T cell percentages, total cell counts with their ratios, as well as CD16/56 natural killer cell percentages and cell counts. Total white blood cell counts normalized within 10 days after the SB drug administrations. The total lymphocyte counts were slightly increased, but remained within normal parameters. CD4 and CD8 T cells, as well as CD 16/56 NK cell percentages, became normal within 10 days; their total cell counts were initially increased (26.3%, 45.2%, and 16.7%, respectively) and then became normal. The SB drug was found to be effective cytoapoptotically and was also effective for immune cell recovery in cancer patients in their initial period of the SB drug treatment. These were patients who had already had a bone marrow suppression by cancer invasion and/or prior chemotherapy.
    VL  - 6
    IS  - 2
    ER  - 

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