Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults

Stephanie London; Kathy Yates; Antonio Convit

doi:doi:10.11648/j.ajpn.20180604.14

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Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults

Stephanie London, Kathy Yates, Antonio Convit

Published in American Journal of Psychiatry and Neuroscience (Volume 6, Issue 4)

Received: 13 November 2018 Accepted: 28 November 2018 Published: 21 December 2018

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Abstract

The aim of this study was to determine whether effects of insulin resistance (IR) on frontal lobe mediated abilities differ between adolescents and middle-aged adults. These analyses included 118 adolescents aged 16-21 and 118 adults aged 45-60. IR was defined as having a homeostasis model assessment of insulin resistance (HOMA-IR) > 3.99. These analyses focused on higher-order frontal lobe-mediated function and assessed the differential effects of IR by age group on eight targeted cognitive/functional measures. There were significant differences between adolescents who were insulin sensitive (IS) and those with IR on the Stroop interference score (Cohen’s d = 0.61) and Frontal Systems Behavior Scale (FrSBe) executive dysfunction (Cohen’s d = -1.00). Adults with and without IR did not differ on any of the selected measures. There were significant interactions between age group and IR status for the Stroop interference score (partial eta² = 0.029) and FrSBe executive dysfunction scale (partial eta² = 0.045). Compared to their IS peers, adolescents with IR performed significantly worse on 2/8 indices of frontal lobe function, while no frontal lobe related cognitive differences existed in the adult population. As anticipated, there was a significant age group by IR status interaction for these higher-order frontal abilities. Poor performance in these measures indicates difficulties in planning, organization and self-regulation, skills that are crucial for life-long learning and achievement of future goals. These data suggest that the still-developing brains of adolescents may render them more vulnerable to the negative effects of metabolic dysregulation than do equivalent metabolic abnormalities in adults.

Published in	American Journal of Psychiatry and Neuroscience (Volume 6, Issue 4)
DOI	10.11648/j.ajpn.20180604.14
Page(s)	108-115
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Insulin Resistance, Metabolic Syndrome, Diabetes, Executive Function, Adolescents

References

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APA Style

Stephanie London, Kathy Yates, Antonio Convit. (2018). Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults. American Journal of Psychiatry and Neuroscience, 6(4), 108-115. https://doi.org/10.11648/j.ajpn.20180604.14

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ACS Style

Stephanie London; Kathy Yates; Antonio Convit. Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults. Am. J. Psychiatry Neurosci. 2018, 6(4), 108-115. doi: 10.11648/j.ajpn.20180604.14

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AMA Style

Stephanie London, Kathy Yates, Antonio Convit. Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults. Am J Psychiatry Neurosci. 2018;6(4):108-115. doi: 10.11648/j.ajpn.20180604.14

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@article{10.11648/j.ajpn.20180604.14,
  author = {Stephanie London and Kathy Yates and Antonio Convit},
  title = {Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {6},
  number = {4},
  pages = {108-115},
  doi = {10.11648/j.ajpn.20180604.14},
  url = {https://doi.org/10.11648/j.ajpn.20180604.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20180604.14},
  abstract = {The aim of this study was to determine whether effects of insulin resistance (IR) on frontal lobe mediated abilities differ between adolescents and middle-aged adults. These analyses included 118 adolescents aged 16-21 and 118 adults aged 45-60. IR was defined as having a homeostasis model assessment of insulin resistance (HOMA-IR) > 3.99. These analyses focused on higher-order frontal lobe-mediated function and assessed the differential effects of IR by age group on eight targeted cognitive/functional measures. There were significant differences between adolescents who were insulin sensitive (IS) and those with IR on the Stroop interference score (Cohen’s d = 0.61) and Frontal Systems Behavior Scale (FrSBe) executive dysfunction (Cohen’s d = -1.00). Adults with and without IR did not differ on any of the selected measures. There were significant interactions between age group and IR status for the Stroop interference score (partial eta2 = 0.029) and FrSBe executive dysfunction scale (partial eta2 = 0.045). Compared to their IS peers, adolescents with IR performed significantly worse on 2/8 indices of frontal lobe function, while no frontal lobe related cognitive differences existed in the adult population. As anticipated, there was a significant age group by IR status interaction for these higher-order frontal abilities. Poor performance in these measures indicates difficulties in planning, organization and self-regulation, skills that are crucial for life-long learning and achievement of future goals. These data suggest that the still-developing brains of adolescents may render them more vulnerable to the negative effects of metabolic dysregulation than do equivalent metabolic abnormalities in adults.},
 year = {2018}
}

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TY  - JOUR
T1  - Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults
AU  - Stephanie London
AU  - Kathy Yates
AU  - Antonio Convit
Y1  - 2018/12/21
PY  - 2018
N1  - https://doi.org/10.11648/j.ajpn.20180604.14
DO  - 10.11648/j.ajpn.20180604.14
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 108
EP  - 115
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20180604.14
AB  - The aim of this study was to determine whether effects of insulin resistance (IR) on frontal lobe mediated abilities differ between adolescents and middle-aged adults. These analyses included 118 adolescents aged 16-21 and 118 adults aged 45-60. IR was defined as having a homeostasis model assessment of insulin resistance (HOMA-IR) > 3.99. These analyses focused on higher-order frontal lobe-mediated function and assessed the differential effects of IR by age group on eight targeted cognitive/functional measures. There were significant differences between adolescents who were insulin sensitive (IS) and those with IR on the Stroop interference score (Cohen’s d = 0.61) and Frontal Systems Behavior Scale (FrSBe) executive dysfunction (Cohen’s d = -1.00). Adults with and without IR did not differ on any of the selected measures. There were significant interactions between age group and IR status for the Stroop interference score (partial eta2 = 0.029) and FrSBe executive dysfunction scale (partial eta2 = 0.045). Compared to their IS peers, adolescents with IR performed significantly worse on 2/8 indices of frontal lobe function, while no frontal lobe related cognitive differences existed in the adult population. As anticipated, there was a significant age group by IR status interaction for these higher-order frontal abilities. Poor performance in these measures indicates difficulties in planning, organization and self-regulation, skills that are crucial for life-long learning and achievement of future goals. These data suggest that the still-developing brains of adolescents may render them more vulnerable to the negative effects of metabolic dysregulation than do equivalent metabolic abnormalities in adults.
VL  - 6
IS  - 4
ER  -

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Author Information

Stephanie London

Department of Psychiatry, New York University School of Medicine, New York, USA
Kathy Yates

Department of Psychiatry, New York University School of Medicine, New York, USA; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
Antonio Convit

Department of Psychiatry, New York University School of Medicine, New York, USA; Department of Medicine, New York University School of Medicine, New York, USA; Department of Radiology, New York University School of Medicine, New York, USA; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA

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Stephanie London, Kathy Yates, Antonio Convit. (2018). Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults. American Journal of Psychiatry and Neuroscience, 6(4), 108-115. https://doi.org/10.11648/j.ajpn.20180604.14

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ACS Style

Stephanie London; Kathy Yates; Antonio Convit. Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults. Am. J. Psychiatry Neurosci. 2018, 6(4), 108-115. doi: 10.11648/j.ajpn.20180604.14

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AMA Style

Stephanie London, Kathy Yates, Antonio Convit. Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults. Am J Psychiatry Neurosci. 2018;6(4):108-115. doi: 10.11648/j.ajpn.20180604.14

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@article{10.11648/j.ajpn.20180604.14,
  author = {Stephanie London and Kathy Yates and Antonio Convit},
  title = {Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {6},
  number = {4},
  pages = {108-115},
  doi = {10.11648/j.ajpn.20180604.14},
  url = {https://doi.org/10.11648/j.ajpn.20180604.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20180604.14},
  abstract = {The aim of this study was to determine whether effects of insulin resistance (IR) on frontal lobe mediated abilities differ between adolescents and middle-aged adults. These analyses included 118 adolescents aged 16-21 and 118 adults aged 45-60. IR was defined as having a homeostasis model assessment of insulin resistance (HOMA-IR) > 3.99. These analyses focused on higher-order frontal lobe-mediated function and assessed the differential effects of IR by age group on eight targeted cognitive/functional measures. There were significant differences between adolescents who were insulin sensitive (IS) and those with IR on the Stroop interference score (Cohen’s d = 0.61) and Frontal Systems Behavior Scale (FrSBe) executive dysfunction (Cohen’s d = -1.00). Adults with and without IR did not differ on any of the selected measures. There were significant interactions between age group and IR status for the Stroop interference score (partial eta2 = 0.029) and FrSBe executive dysfunction scale (partial eta2 = 0.045). Compared to their IS peers, adolescents with IR performed significantly worse on 2/8 indices of frontal lobe function, while no frontal lobe related cognitive differences existed in the adult population. As anticipated, there was a significant age group by IR status interaction for these higher-order frontal abilities. Poor performance in these measures indicates difficulties in planning, organization and self-regulation, skills that are crucial for life-long learning and achievement of future goals. These data suggest that the still-developing brains of adolescents may render them more vulnerable to the negative effects of metabolic dysregulation than do equivalent metabolic abnormalities in adults.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Differential Effects of Insulin Resistance on Frontal Lobe Related Cognitive Function in Adolescents and Adults
AU  - Stephanie London
AU  - Kathy Yates
AU  - Antonio Convit
Y1  - 2018/12/21
PY  - 2018
N1  - https://doi.org/10.11648/j.ajpn.20180604.14
DO  - 10.11648/j.ajpn.20180604.14
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 108
EP  - 115
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20180604.14
AB  - The aim of this study was to determine whether effects of insulin resistance (IR) on frontal lobe mediated abilities differ between adolescents and middle-aged adults. These analyses included 118 adolescents aged 16-21 and 118 adults aged 45-60. IR was defined as having a homeostasis model assessment of insulin resistance (HOMA-IR) > 3.99. These analyses focused on higher-order frontal lobe-mediated function and assessed the differential effects of IR by age group on eight targeted cognitive/functional measures. There were significant differences between adolescents who were insulin sensitive (IS) and those with IR on the Stroop interference score (Cohen’s d = 0.61) and Frontal Systems Behavior Scale (FrSBe) executive dysfunction (Cohen’s d = -1.00). Adults with and without IR did not differ on any of the selected measures. There were significant interactions between age group and IR status for the Stroop interference score (partial eta2 = 0.029) and FrSBe executive dysfunction scale (partial eta2 = 0.045). Compared to their IS peers, adolescents with IR performed significantly worse on 2/8 indices of frontal lobe function, while no frontal lobe related cognitive differences existed in the adult population. As anticipated, there was a significant age group by IR status interaction for these higher-order frontal abilities. Poor performance in these measures indicates difficulties in planning, organization and self-regulation, skills that are crucial for life-long learning and achievement of future goals. These data suggest that the still-developing brains of adolescents may render them more vulnerable to the negative effects of metabolic dysregulation than do equivalent metabolic abnormalities in adults.
VL  - 6
IS  - 4
ER  -

Copy | Download