Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders

Beatriz Camarena; Sandra Hernandez; Laura Gonzalez; Griselda Flores; David Luna; Alejandro Aguilar; Alejandro Caballero

doi:doi:10.11648/j.ajpn.20180604.13

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Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders

Beatriz Camarena, Sandra Hernandez, Laura Gonzalez, Griselda Flores, David Luna, Alejandro Aguilar, Alejandro Caballero

Published in American Journal of Psychiatry and Neuroscience (Volume 6, Issue 4)

Received: 2 October 2018 Accepted: 24 October 2018 Published: 21 December 2018

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Abstract

The serotonin transporter is encoded by the SLC6A4 gene and has been an interesting candidate for anorexia nervosa (AN) and bulimia nervosa (BN). The present study analyzed the association between the triallelic model of the SLC6A4 gene and eating disorders in Mexican population. Materials and Methods: The 5-HTTLPR/rs25531 polymorphism was analyzed in 458 eating disorder patients and 337 control subjects. Genotype and allele analyses were examined in 206 BN and 79 AN patients and compared with the control group. Furthermore, genotype and allele analyses were performed on AN-Spectrum (AN-R, AN-BP and AN-EDNOS) and BN-Spectrum (BN-P, BN-NP and BN-EDNOS) groups and compared with the control group. Results: Case-control analysis showed that BN patients had an increased frequency of the S/LG alleles compared to controls (c2=6.9, df=1, p=0.0088). However, no association was found between AN and the 5-HTTLPR/rs25531 polymorphism (c2=3.3, df=1, p=0.0654). Also, an association was observed in genotype distribution when comparing AN-spectrum and control groups (c2=10.1, df=2, p=0.0069); however, analysis of allele frequencies did not show differences after Bonferroni correction (c2=5.6, df=1, p=0.0177). Finally, analysis of BN-Spectrum showed a high frequency of S/L_G alleles compared to control group (c2=7.3, df=1, p=0.007). Conclusion: The low activity alleles of the 5- HTTLPR/rs25531 polymorphism of the SLC6A4 gene may play a significant role in the etiology of BN subtypes in Mexican population.

Published in	American Journal of Psychiatry and Neuroscience (Volume 6, Issue 4)
DOI	10.11648/j.ajpn.20180604.13
Page(s)	104-107
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Anorexia Nervosa, Bulimia Nervosa, Serotonin Transporter, 5-HTTLPR, rs25531

References

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APA Style

Beatriz Camarena, Sandra Hernandez, Laura Gonzalez, Griselda Flores, David Luna, et al. (2018). Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders. American Journal of Psychiatry and Neuroscience, 6(4), 104-107. https://doi.org/10.11648/j.ajpn.20180604.13

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ACS Style

Beatriz Camarena; Sandra Hernandez; Laura Gonzalez; Griselda Flores; David Luna, et al. Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders. Am. J. Psychiatry Neurosci. 2018, 6(4), 104-107. doi: 10.11648/j.ajpn.20180604.13

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AMA Style

Beatriz Camarena, Sandra Hernandez, Laura Gonzalez, Griselda Flores, David Luna, et al. Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders. Am J Psychiatry Neurosci. 2018;6(4):104-107. doi: 10.11648/j.ajpn.20180604.13

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@article{10.11648/j.ajpn.20180604.13,
  author = {Beatriz Camarena and Sandra Hernandez and Laura Gonzalez and Griselda Flores and David Luna and Alejandro Aguilar and Alejandro Caballero},
  title = {Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {6},
  number = {4},
  pages = {104-107},
  doi = {10.11648/j.ajpn.20180604.13},
  url = {https://doi.org/10.11648/j.ajpn.20180604.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20180604.13},
  abstract = {The serotonin transporter is encoded by the SLC6A4 gene and has been an interesting candidate for anorexia nervosa (AN) and bulimia nervosa (BN). The present study analyzed the association between the triallelic model of the SLC6A4 gene and eating disorders in Mexican population. Materials and Methods: The 5-HTTLPR/rs25531 polymorphism was analyzed in 458 eating disorder patients and 337 control subjects. Genotype and allele analyses were examined in 206 BN and 79 AN patients and compared with the control group. Furthermore, genotype and allele analyses were performed on AN-Spectrum (AN-R, AN-BP and AN-EDNOS) and BN-Spectrum (BN-P, BN-NP and BN-EDNOS) groups and compared with the control group. Results: Case-control analysis showed that BN patients had an increased frequency of the S/LG alleles compared to controls (c2=6.9, df=1, p=0.0088). However, no association was found between AN and the 5-HTTLPR/rs25531 polymorphism (c2=3.3, df=1, p=0.0654). Also, an association was observed in genotype distribution when comparing AN-spectrum and control groups (c2=10.1, df=2, p=0.0069); however, analysis of allele frequencies did not show differences after Bonferroni correction (c2=5.6, df=1, p=0.0177). Finally, analysis of BN-Spectrum showed a high frequency of S/LG alleles compared to control group (c2=7.3, df=1, p=0.007). Conclusion: The low activity alleles of the 5- HTTLPR/rs25531 polymorphism of the SLC6A4 gene may play a significant role in the etiology of BN subtypes in Mexican population.},
 year = {2018}
}

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TY  - JOUR
T1  - Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders
AU  - Beatriz Camarena
AU  - Sandra Hernandez
AU  - Laura Gonzalez
AU  - Griselda Flores
AU  - David Luna
AU  - Alejandro Aguilar
AU  - Alejandro Caballero
Y1  - 2018/12/21
PY  - 2018
N1  - https://doi.org/10.11648/j.ajpn.20180604.13
DO  - 10.11648/j.ajpn.20180604.13
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 104
EP  - 107
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20180604.13
AB  - The serotonin transporter is encoded by the SLC6A4 gene and has been an interesting candidate for anorexia nervosa (AN) and bulimia nervosa (BN). The present study analyzed the association between the triallelic model of the SLC6A4 gene and eating disorders in Mexican population. Materials and Methods: The 5-HTTLPR/rs25531 polymorphism was analyzed in 458 eating disorder patients and 337 control subjects. Genotype and allele analyses were examined in 206 BN and 79 AN patients and compared with the control group. Furthermore, genotype and allele analyses were performed on AN-Spectrum (AN-R, AN-BP and AN-EDNOS) and BN-Spectrum (BN-P, BN-NP and BN-EDNOS) groups and compared with the control group. Results: Case-control analysis showed that BN patients had an increased frequency of the S/LG alleles compared to controls (c2=6.9, df=1, p=0.0088). However, no association was found between AN and the 5-HTTLPR/rs25531 polymorphism (c2=3.3, df=1, p=0.0654). Also, an association was observed in genotype distribution when comparing AN-spectrum and control groups (c2=10.1, df=2, p=0.0069); however, analysis of allele frequencies did not show differences after Bonferroni correction (c2=5.6, df=1, p=0.0177). Finally, analysis of BN-Spectrum showed a high frequency of S/LG alleles compared to control group (c2=7.3, df=1, p=0.007). Conclusion: The low activity alleles of the 5- HTTLPR/rs25531 polymorphism of the SLC6A4 gene may play a significant role in the etiology of BN subtypes in Mexican population.
VL  - 6
IS  - 4
ER  -

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Author Information

Beatriz Camarena

Department of Pharmacogenetics, National Institute of Psychiatry Ramon de la Fuente Mu?iz, Mexico City, Mexico
Sandra Hernandez

Department of Pharmacogenetics, National Institute of Psychiatry Ramon de la Fuente Mu?iz, Mexico City, Mexico
Laura Gonzalez

Eating Disorders Clinic, National Institute of Psychiatry Ramon de la Fuente Mu?iz, Mexico City, Mexico
Griselda Flores

Hospital and Continuous Psychiatric Care, National Institute of Psychiatry Ramon de la Fuente Mu?iz, Mexico City, Mexico
David Luna

Eating Disorders Clinic, National Institute of Psychiatry Ramon de la Fuente Mu?iz, Mexico City, Mexico
Alejandro Aguilar

Department of Pharmacogenetics, National Institute of Psychiatry Ramon de la Fuente Mu?iz, Mexico City, Mexico
Alejandro Caballero

Eating Disorders Clinic, National Institute of Psychiatry Ramon de la Fuente Mu?iz, Mexico City, Mexico

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Plain Text BibTeX RIS

APA Style

Beatriz Camarena, Sandra Hernandez, Laura Gonzalez, Griselda Flores, David Luna, et al. (2018). Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders. American Journal of Psychiatry and Neuroscience, 6(4), 104-107. https://doi.org/10.11648/j.ajpn.20180604.13

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ACS Style

Beatriz Camarena; Sandra Hernandez; Laura Gonzalez; Griselda Flores; David Luna, et al. Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders. Am. J. Psychiatry Neurosci. 2018, 6(4), 104-107. doi: 10.11648/j.ajpn.20180604.13

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AMA Style

Beatriz Camarena, Sandra Hernandez, Laura Gonzalez, Griselda Flores, David Luna, et al. Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders. Am J Psychiatry Neurosci. 2018;6(4):104-107. doi: 10.11648/j.ajpn.20180604.13

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@article{10.11648/j.ajpn.20180604.13,
  author = {Beatriz Camarena and Sandra Hernandez and Laura Gonzalez and Griselda Flores and David Luna and Alejandro Aguilar and Alejandro Caballero},
  title = {Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {6},
  number = {4},
  pages = {104-107},
  doi = {10.11648/j.ajpn.20180604.13},
  url = {https://doi.org/10.11648/j.ajpn.20180604.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20180604.13},
  abstract = {The serotonin transporter is encoded by the SLC6A4 gene and has been an interesting candidate for anorexia nervosa (AN) and bulimia nervosa (BN). The present study analyzed the association between the triallelic model of the SLC6A4 gene and eating disorders in Mexican population. Materials and Methods: The 5-HTTLPR/rs25531 polymorphism was analyzed in 458 eating disorder patients and 337 control subjects. Genotype and allele analyses were examined in 206 BN and 79 AN patients and compared with the control group. Furthermore, genotype and allele analyses were performed on AN-Spectrum (AN-R, AN-BP and AN-EDNOS) and BN-Spectrum (BN-P, BN-NP and BN-EDNOS) groups and compared with the control group. Results: Case-control analysis showed that BN patients had an increased frequency of the S/LG alleles compared to controls (c2=6.9, df=1, p=0.0088). However, no association was found between AN and the 5-HTTLPR/rs25531 polymorphism (c2=3.3, df=1, p=0.0654). Also, an association was observed in genotype distribution when comparing AN-spectrum and control groups (c2=10.1, df=2, p=0.0069); however, analysis of allele frequencies did not show differences after Bonferroni correction (c2=5.6, df=1, p=0.0177). Finally, analysis of BN-Spectrum showed a high frequency of S/LG alleles compared to control group (c2=7.3, df=1, p=0.007). Conclusion: The low activity alleles of the 5- HTTLPR/rs25531 polymorphism of the SLC6A4 gene may play a significant role in the etiology of BN subtypes in Mexican population.},
 year = {2018}
}

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TY  - JOUR
T1  - Association Study Between the Triallelic Polymorphism of SLC6A4 Gene and Eating Disorders
AU  - Beatriz Camarena
AU  - Sandra Hernandez
AU  - Laura Gonzalez
AU  - Griselda Flores
AU  - David Luna
AU  - Alejandro Aguilar
AU  - Alejandro Caballero
Y1  - 2018/12/21
PY  - 2018
N1  - https://doi.org/10.11648/j.ajpn.20180604.13
DO  - 10.11648/j.ajpn.20180604.13
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 104
EP  - 107
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20180604.13
AB  - The serotonin transporter is encoded by the SLC6A4 gene and has been an interesting candidate for anorexia nervosa (AN) and bulimia nervosa (BN). The present study analyzed the association between the triallelic model of the SLC6A4 gene and eating disorders in Mexican population. Materials and Methods: The 5-HTTLPR/rs25531 polymorphism was analyzed in 458 eating disorder patients and 337 control subjects. Genotype and allele analyses were examined in 206 BN and 79 AN patients and compared with the control group. Furthermore, genotype and allele analyses were performed on AN-Spectrum (AN-R, AN-BP and AN-EDNOS) and BN-Spectrum (BN-P, BN-NP and BN-EDNOS) groups and compared with the control group. Results: Case-control analysis showed that BN patients had an increased frequency of the S/LG alleles compared to controls (c2=6.9, df=1, p=0.0088). However, no association was found between AN and the 5-HTTLPR/rs25531 polymorphism (c2=3.3, df=1, p=0.0654). Also, an association was observed in genotype distribution when comparing AN-spectrum and control groups (c2=10.1, df=2, p=0.0069); however, analysis of allele frequencies did not show differences after Bonferroni correction (c2=5.6, df=1, p=0.0177). Finally, analysis of BN-Spectrum showed a high frequency of S/LG alleles compared to control group (c2=7.3, df=1, p=0.007). Conclusion: The low activity alleles of the 5- HTTLPR/rs25531 polymorphism of the SLC6A4 gene may play a significant role in the etiology of BN subtypes in Mexican population.
VL  - 6
IS  - 4
ER  -

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