Aluminum is a ubiquitous toxic metal that mainly affects brain, bone, spleen, liver, kidney, hepatic hematopoietic system. This study investigated the effect of Curcumin and Curcumin Nanoparticles on reduced the toxicity of aluminum chloride in treated rats. Six groups of rats were used: (1) control; (2) curcumin-treated rats (15 mg curcumin /Kg BW; (3) Nano-curcumin -treated rats (15 mg Nano-curcumin /Kg BW); (4) aluminum chloride-treated rats (100 mg/kg BW); (5) AlCl3- curcumin-treated rats (100 mg AlCl3 and 15 mg curcumin/kg BW); (6) AlCl3- Nano-curcumin -treated rats (100 mg AlCl3 and 15 mg Nano-curcumin /kg BW). The treatment with AlCl3 alone caused significant (P≤ 0.05) increased in liver and kidney functions of rats, while the oral intake of curcumin and Nano-curcumin eliminate the harmful effect of AlCl3. On the same side, the treatment with AlCl3 alone significantly (P≤ 0.05) increase the free radical level and decreased the activities of antioxidant enzymes in plasma, while the treatment with curcumin and Nano-curcumin reduced this increased in free radicals and increased the activities of antioxidant enzymes. These results confirmed that the curcumin and Nano-curcumin reduced the toxicity effect of AlCl3 in rats; moreover, Nano-curcumin has a best biological and antioxidant activity than curcumin in healthy and AlCl3-treated rats.
| Published in | International Journal of Food Science and Biotechnology (Volume 4, Issue 3) |
| DOI | 10.11648/j.ijfsb.20190403.12 |
| Page(s) | 64-73 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Curcumin, Nano-curcumin, Aluminum Toxicity, Nano-Toxicology
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APA Style
Rehab Mohamed Ibrahim, Fatma El Zahraa Ali Abd Elaal, Sahar Zaki. (2019). Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats. International Journal of Food Science and Biotechnology, 4(3), 64-73. https://doi.org/10.11648/j.ijfsb.20190403.12
ACS Style
Rehab Mohamed Ibrahim; Fatma El Zahraa Ali Abd Elaal; Sahar Zaki. Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats. Int. J. Food Sci. Biotechnol. 2019, 4(3), 64-73. doi: 10.11648/j.ijfsb.20190403.12
AMA Style
Rehab Mohamed Ibrahim, Fatma El Zahraa Ali Abd Elaal, Sahar Zaki. Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats. Int J Food Sci Biotechnol. 2019;4(3):64-73. doi: 10.11648/j.ijfsb.20190403.12
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Download@article{10.11648/j.ijfsb.20190403.12,
author = {Rehab Mohamed Ibrahim and Fatma El Zahraa Ali Abd Elaal and Sahar Zaki},
title = {Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats},
journal = {International Journal of Food Science and Biotechnology},
volume = {4},
number = {3},
pages = {64-73},
doi = {10.11648/j.ijfsb.20190403.12},
url = {https://doi.org/10.11648/j.ijfsb.20190403.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijfsb.20190403.12},
abstract = {Aluminum is a ubiquitous toxic metal that mainly affects brain, bone, spleen, liver, kidney, hepatic hematopoietic system. This study investigated the effect of Curcumin and Curcumin Nanoparticles on reduced the toxicity of aluminum chloride in treated rats. Six groups of rats were used: (1) control; (2) curcumin-treated rats (15 mg curcumin /Kg BW; (3) Nano-curcumin -treated rats (15 mg Nano-curcumin /Kg BW); (4) aluminum chloride-treated rats (100 mg/kg BW); (5) AlCl3- curcumin-treated rats (100 mg AlCl3 and 15 mg curcumin/kg BW); (6) AlCl3- Nano-curcumin -treated rats (100 mg AlCl3 and 15 mg Nano-curcumin /kg BW). The treatment with AlCl3 alone caused significant (P≤ 0.05) increased in liver and kidney functions of rats, while the oral intake of curcumin and Nano-curcumin eliminate the harmful effect of AlCl3. On the same side, the treatment with AlCl3 alone significantly (P≤ 0.05) increase the free radical level and decreased the activities of antioxidant enzymes in plasma, while the treatment with curcumin and Nano-curcumin reduced this increased in free radicals and increased the activities of antioxidant enzymes. These results confirmed that the curcumin and Nano-curcumin reduced the toxicity effect of AlCl3 in rats; moreover, Nano-curcumin has a best biological and antioxidant activity than curcumin in healthy and AlCl3-treated rats.},
year = {2019}
}
TY - JOUR T1 - Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats AU - Rehab Mohamed Ibrahim AU - Fatma El Zahraa Ali Abd Elaal AU - Sahar Zaki Y1 - 2019/10/09 PY - 2019 N1 - https://doi.org/10.11648/j.ijfsb.20190403.12 DO - 10.11648/j.ijfsb.20190403.12 T2 - International Journal of Food Science and Biotechnology JF - International Journal of Food Science and Biotechnology JO - International Journal of Food Science and Biotechnology SP - 64 EP - 73 PB - Science Publishing Group SN - 2578-9643 UR - https://doi.org/10.11648/j.ijfsb.20190403.12 AB - Aluminum is a ubiquitous toxic metal that mainly affects brain, bone, spleen, liver, kidney, hepatic hematopoietic system. This study investigated the effect of Curcumin and Curcumin Nanoparticles on reduced the toxicity of aluminum chloride in treated rats. Six groups of rats were used: (1) control; (2) curcumin-treated rats (15 mg curcumin /Kg BW; (3) Nano-curcumin -treated rats (15 mg Nano-curcumin /Kg BW); (4) aluminum chloride-treated rats (100 mg/kg BW); (5) AlCl3- curcumin-treated rats (100 mg AlCl3 and 15 mg curcumin/kg BW); (6) AlCl3- Nano-curcumin -treated rats (100 mg AlCl3 and 15 mg Nano-curcumin /kg BW). The treatment with AlCl3 alone caused significant (P≤ 0.05) increased in liver and kidney functions of rats, while the oral intake of curcumin and Nano-curcumin eliminate the harmful effect of AlCl3. On the same side, the treatment with AlCl3 alone significantly (P≤ 0.05) increase the free radical level and decreased the activities of antioxidant enzymes in plasma, while the treatment with curcumin and Nano-curcumin reduced this increased in free radicals and increased the activities of antioxidant enzymes. These results confirmed that the curcumin and Nano-curcumin reduced the toxicity effect of AlCl3 in rats; moreover, Nano-curcumin has a best biological and antioxidant activity than curcumin in healthy and AlCl3-treated rats. VL - 4 IS - 3 ER -
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