International Journal of Neurosurgery

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Assessment of Cerebrospinal Fluid Neurogranin as a Predictor of Alzeheimer’s Disease Through Synaptic Dysfunction

Received: 06 April 2018    Accepted: 24 April 2018    Published: 24 May 2018
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Abstract

Cognitive changes in Alzheimer’s diseases have been linked to synaptic degeneration and dysfunction. Hence, a biomarker of early synaptic defect like neurogranin, is clinically useful to enhance early diagnosis of the disease in susceptible individuals. This review ass the various works done by various authors and researchers from various parts of the world on the role of neurogranin and its clinical usefulness in the early diagnosis of Alzheimer’s disease, a degenerative brain disease with symptoms of progressive dementia. Using the internet and search engines as pubmed, google scholar, medline, index Copernicus etc, studies on Alzheimer’s disease biomarkers and neurogranin were checked for to assess the conclusions of the researchers and also references of the retrieved articles were searched for further facts and information on the subject. Over the years, many researchers have been done to ascertain a suitable biomarker for Alzheimers disease. The pathophysiological process of Alzheimher’s is linked to synaptic degeneration and elevated cerebrospinal fluid neurogranin has been linked to this pathologic process. In this review, many authors find neurogranin a useful, accurate and reliable biomarker in the diagnosis and prognosis of Alzheimer’s disease as neurogranin levels are elevated in patients with Alzheimer’s disease when compared with controls. Elevated cerebrospinal fluid (CSF) levels of neurogranin is a promising biomarker of Alzheimer’s diseases and tends to be clinically useful in early diagnosis and prognosis of the disease.

DOI 10.11648/j.ijn.20180201.13
Published in International Journal of Neurosurgery (Volume 2, Issue 1, June 2018)
Page(s) 13-16
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Alzheimer’s, Biomarkers, Pubmed, Neuropilin, Cerebrospinal Fluid, Synaptic

References
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Author Information
  • Department of Chemical Pathology, University of Calabar, Calabar, Nigeria

  • Department of Medicine and Surgery, University of Calabar, Calabar, Nigeria

  • Department of Medicine and Surgery, University of Calabar, Calabar, Nigeria

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    Ekpe Lawson, Aniara Gloria, Eman-Henshaw Offiong. (2018). Assessment of Cerebrospinal Fluid Neurogranin as a Predictor of Alzeheimer’s Disease Through Synaptic Dysfunction. International Journal of Neurosurgery, 2(1), 13-16. https://doi.org/10.11648/j.ijn.20180201.13

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    ACS Style

    Ekpe Lawson; Aniara Gloria; Eman-Henshaw Offiong. Assessment of Cerebrospinal Fluid Neurogranin as a Predictor of Alzeheimer’s Disease Through Synaptic Dysfunction. Int. J. Neurosurg. 2018, 2(1), 13-16. doi: 10.11648/j.ijn.20180201.13

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    AMA Style

    Ekpe Lawson, Aniara Gloria, Eman-Henshaw Offiong. Assessment of Cerebrospinal Fluid Neurogranin as a Predictor of Alzeheimer’s Disease Through Synaptic Dysfunction. Int J Neurosurg. 2018;2(1):13-16. doi: 10.11648/j.ijn.20180201.13

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  • @article{10.11648/j.ijn.20180201.13,
      author = {Ekpe Lawson and Aniara Gloria and Eman-Henshaw Offiong},
      title = {Assessment of Cerebrospinal Fluid Neurogranin as a Predictor of Alzeheimer’s Disease Through Synaptic Dysfunction},
      journal = {International Journal of Neurosurgery},
      volume = {2},
      number = {1},
      pages = {13-16},
      doi = {10.11648/j.ijn.20180201.13},
      url = {https://doi.org/10.11648/j.ijn.20180201.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijn.20180201.13},
      abstract = {Cognitive changes in Alzheimer’s diseases have been linked to synaptic degeneration and dysfunction. Hence, a biomarker of early synaptic defect like neurogranin, is clinically useful to enhance early diagnosis of the disease in susceptible individuals. This review ass the various works done by various authors and researchers from various parts of the world on the role of neurogranin and its clinical usefulness in the early diagnosis of Alzheimer’s disease, a degenerative brain disease with symptoms of progressive dementia. Using the internet and search engines as pubmed, google scholar, medline, index Copernicus etc, studies on Alzheimer’s disease biomarkers and neurogranin were checked for to assess the conclusions of the researchers and also references of the retrieved articles were searched for further facts and information on the subject. Over the years, many researchers have been done to ascertain a suitable biomarker for Alzheimers disease. The pathophysiological process of Alzheimher’s is linked to synaptic degeneration and elevated cerebrospinal fluid neurogranin has been linked to this pathologic process. In this review, many authors find neurogranin a useful, accurate and reliable biomarker in the diagnosis and prognosis of Alzheimer’s disease as neurogranin levels are elevated in patients with Alzheimer’s disease when compared with controls. Elevated cerebrospinal fluid (CSF) levels of neurogranin is a promising biomarker of Alzheimer’s diseases and tends to be clinically useful in early diagnosis and prognosis of the disease.},
     year = {2018}
    }
    

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    AU  - Ekpe Lawson
    AU  - Aniara Gloria
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    AB  - Cognitive changes in Alzheimer’s diseases have been linked to synaptic degeneration and dysfunction. Hence, a biomarker of early synaptic defect like neurogranin, is clinically useful to enhance early diagnosis of the disease in susceptible individuals. This review ass the various works done by various authors and researchers from various parts of the world on the role of neurogranin and its clinical usefulness in the early diagnosis of Alzheimer’s disease, a degenerative brain disease with symptoms of progressive dementia. Using the internet and search engines as pubmed, google scholar, medline, index Copernicus etc, studies on Alzheimer’s disease biomarkers and neurogranin were checked for to assess the conclusions of the researchers and also references of the retrieved articles were searched for further facts and information on the subject. Over the years, many researchers have been done to ascertain a suitable biomarker for Alzheimers disease. The pathophysiological process of Alzheimher’s is linked to synaptic degeneration and elevated cerebrospinal fluid neurogranin has been linked to this pathologic process. In this review, many authors find neurogranin a useful, accurate and reliable biomarker in the diagnosis and prognosis of Alzheimer’s disease as neurogranin levels are elevated in patients with Alzheimer’s disease when compared with controls. Elevated cerebrospinal fluid (CSF) levels of neurogranin is a promising biomarker of Alzheimer’s diseases and tends to be clinically useful in early diagnosis and prognosis of the disease.
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